| 王 丹1, 鄢小燕1, 彭明友 1, 张 雄1, 王建塔1, 汤 磊1, 晏 英1,2* |
| 1. 贵州医科大学 药学院, 贵州省化学合成药物研发利用工程技术研究中心, 贵阳 550004;2. 贵州医科大学 医药卫生管理学院, 贵阳 550025 |
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| 摘要: |
| 为明确鹧鸪花枝叶的化学物质基础,该研究采用硅胶柱色谱、MCI、C18、Sephadex LH-20及制备HPLC等色谱技术对其进行分离和纯化,并通过理化性质和波谱数据鉴定化合物的结构。结果表明:(1)从鹧鸪花枝、叶的甲醇提取物中分离得到6个单体化合物,分别鉴定为新化合物8-O-4'-木脂素,即heynealigan A(1)、3β,21-dihydroxy-24-methylenecycloartane(2)、3-oxo-threo-23,24,25-trihydroxytirucall-7-ene(3)、16-dehydeoxy-23β-hydroxymeliasenin F(4)、ergost-5, 24(28)-diene-3β, 23S-diol(5)、7α-羟基谷甾醇(6)。(2)化合物1为新的木脂素,化合物2-4为三萜化合物,化合物5和化合物6为甾体化合物,化合物2-5为首次从该植物中分离得到。该研究结果为鹧鸪花的合理开发利用提供了科学依据。 |
| 关键词: 鹧鸪花, 化学成分, 分离纯化, 结构鉴定, 8-O-4'-木脂素 |
| DOI：10.11931/guihaia.gxzw202203006 |
| 分类号:Q946 |
| 文章编号:1000-3142(2023)01-0126-06 |
| 基金项目:国家自然科学基金(31760089); 贵州医科大学学术新苗项目(19NSP083)。 |
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| A new lignan from Heynea trijuga |
| WANG Dan1, YAN Xiaoyan1, PENG Mingyou1, ZHANG Xiong1, WANG Jianta1, TANG Lei1, YAN Ying1,2* |
| 1. Engineering Technology Research Center for Chemical Drug R &2.D, College of Pharmacy, Guizhou Medical University, Guiyang 55004, China;3.2. College of Medicine and Health Administration, Guizhou Medical University, Guiyang 550025, China |
| Abstract: |
| In order to study the chemical constituents from the branches and leaves of Heynea trijuga, silica gel, MCI, C18, Sephadex LH-20 and preparative HPLC were applied for the isolation and purification of the constituents. The structures were identified by physicochemical properties and spectrum data. The results were as follows:(1)Six compounds were obtained from methanol extracts of H. trijuga, their structures were identified as heynealigan A(1), 3β,21-dihydroxy-24-methylenecycloartane(2), 3-oxo-threo-23,24,25-trihydroxytirucall-7-ene(3), 16-dehydeoxy-23β-hydroxyliasenin F(4), ergost-5, 24(28)-diene-3β, 23S-diol(5), 7α-hydrositosteol(6).(2)Compound 1 was a new lignan, compounds 2-4 were triterpenoids, compounds 5 and 6 were steroids, and compounds 2-5 were isolated from this plant for the first time. This study provides scientific basis for the rational development and utilization of T. connaroides. |
| Key words: Heynea trijuga, chemical constituents, isolation and purification, structural identification, heynealigan A |
鹧鸪花中一个新的木脂素.pdf
