江赐忠——同济大学特聘教授、博士生导师

专家信息：

江赐忠，男，1974年生，福建人，长聘教授，二级教授，博士生导师，国家重大科学研究计划首席科学家，同济大学生物信息系特聘教授，同济大学转化医学高等研究院教授，课题组组长。

南开大学学士与硕士，美国爱荷华州立大学（Iowa State University）遗传学博士。毕业后先后在美国冷泉港实验室、弗吉尼亚联邦大学、宾夕法尼亚州立大学从事博士后研究。主要研究早期胚胎发育、细胞命运决定与转变、癌症发生发展过程中的表观遗传调控机制。在Nature、Cell Stem Cell、Cell Research、PNAS、Genome Biology、Dev Cell、Adv Sci等期刊发表SCI论文110余篇。主持国家重大科学研究计划项目、国家自然科学基金重大研究计划项目与面上项目10余项。先后获得教育部“新世纪优秀人才”、上海市“浦江人才”、“曙光人才”、“东方学者”特聘教授项目资助。

教育及工作经历：

1995年，毕业于天津南开大学，获学士学位。

1998年，毕业于天津南开大学，获硕士学位

2004年，毕业于美国爱荷华州州立大学，获遗传学博士学位，并辅修生物信 息学和计算机科学。

毕业后先后在美国冷泉港实验室、弗吉尼亚联邦大学、宾夕法尼亚州州立大学进行博士后研究。

2009年，应聘为同济大学特聘教授。

学术兼职：

1、上海市遗传学会理事。

2、广东省高性能计算学会常务理事。

3、上海市实验医学研究院分子诊断创新技术研究所人工智能与大数据技术中心主任。

4、中国抗癌协会肿瘤标志专业委员会委员。

研究领域：

基因在时空上的精确表达受各种表观遗传因素的调控。基因表达差异导致不同的表型，如高矮胖瘦、健康与生病。目前研究较多的表观遗传因素有DNA甲基化、组蛋白修饰、核小体定位、染色质高级结构、非编码RNA、RNA修饰与编辑等。我们课题组聚焦前四种表观四会因素在早期胚胎发育、细胞命运决定、重大疾病中的表观遗传调控机制。

一、早期胚胎发育中的表观遗传调控机制

精卵结合经过卵裂、增殖、分化，形成形态各一功能迥异的不同细胞。这些细胞组合形成组织，多种组织再进一步形成器官，最后形成一个个体。透过现象看本质，这些形态各一功能迥异的细胞都来自一个受精卵，拥有相同的一套基因。但在胚胎发育过程中，相同的一套基因受到精确的表观遗传调控，在时空上表达不同，从而形成形态各一功能迥异的不同组织细胞。在早期胚胎发育中，最初由卵子中带来的RNA与蛋白支撑受精卵发育，很快过渡到由合子基因组启动自身转录表达来支撑受精卵后续的发育，这一过程叫合子基因组启动（也叫母源到合子转变），它对早期胚胎发育至关重要，也受到精确的表观遗传调控。此外，在整个胚胎发育过程中，表观遗传基因调控出现异常，重则导致胚胎发育停滞，轻则导致出生缺陷，给社会与个人家庭带来极大负担与痛苦。我们通过正常受精与体细胞核移植的小鼠早期发育各阶段胚胎，利用多组学技术，通过生物信息学分析与实验验证，研究早期胚胎发育过程中的表观修饰图谱变化，鉴定关键蛋白因子，并探索其对早期胚胎发育的表观遗传调控机制。研究成果对理解和预防发育异常相关疾病有重大意义，在辅助生殖、畜牧业中优良品种及濒危物种的保种育种有重要应用价值。

二、细胞命运决定与转变中的表观遗传调控机制

胚胎干细胞具有全能性，能分化成生物体的各种细胞。反之，经过体细胞重编程，可把已分化的体细胞诱导成具有全/多能性干细胞。另外，对少数类型细胞，通过转分化技术，可直接把一种类型体细胞转变成另一种类型体细胞，即细胞转分化。在上述细胞命运决定与转变过程中，表观遗传调控发挥重要作用。我们课题组利用成熟的体外细胞分化平台、体细胞重编程技术与转分化技术，用二代测序技术测定不同阶段的基因表达、各种表观修饰、关键转录因子全基因组结合位点，通过生物信息学分析与实验验证，探索细胞命运决定与转变中的表观遗传调控机制。研究成果为高效获得高质量的干细胞、前体细胞、特定分化细胞提供理论依据与技术支撑，促进干细胞在基础研究与临床治疗中的应用。

三、癌症发生、发展、转移与耐药的表观遗传调控作用及机制

大量研究表明，许多重大疾病如癌症、老年痴呆等神经退行性疾病都与表观遗传基因调控紊乱有密切关系。癌症是最难治疗的疾病之一，严重危害人类健康。癌症之所以难治疗，是其具有转移与耐药的特性。二者皆与表观遗传调控有密切关系。我们课题组通过体外细胞水平、小鼠体内、与临床样本三个层次，探究癌症干细胞干性维持、癌细胞转移与耐药的表观遗传调控机制，鉴定关键蛋白因子与基因组位点，作为潜在的治疗与药物靶点。研究成果可改善我们对癌症发生、发展、转移与耐药调控机制的理解，最终促进临床上对癌症的诊断与治疗。

研究方向：

(1) 早期胚胎发育中的表观遗传调控机制；

(2) 细胞命运决定与转变中的表观遗传调控机制；

(3) 癌症发生、发展、转移与耐药的表观遗传调控作用及机制

承担科研项目情况：

主持参与了国家“973”重大科学研究计划项目、国家自然基金委重大研究计划与面上项目。

1.“973”重大科学研究计划项目“胚胎发育中的核小体重排与染色质重塑”。 

科研成果：

1. 鉴定、测序和注释了200多个Myb基因，并存入NCBI数据库作为共享资源。

2. 收集整合了哺乳动物中（人、小鼠、大鼠）36个与癌症关联的转录因子家族的成员蛋白因子，并鉴定到这些蛋白因子的共11660个目标基因，识别和标注出这些基因的启动子，以此为基础，构建与癌症关联的基因调控网络，成为癌症研究中的重要资源。

3. 通过单核苷酸多态性分析，证实哺乳动物CpG岛的丢失是由于新的DNA甲基化从岛的边缘开始，慢慢向岛中央“腐蚀”造成的。这一CpG岛丢失机制的证实将极大促进我们对癌症中DNA甲基化这一表观遗传学现象的了解，为设计和研发脱甲基化药物重新激活被沉默的基因作为治疗与DNA甲基化关联的癌症的一个手段打下基础。

4. 近年来利用染色质免疫沉淀结合高通量测序技术，首次在酵母和果蝇中绘制出高分辨率全基因组核小体图谱，并分析核小体定位对基因转录的调控机制等。设计开发了预测、分析核小体及其它蛋白的DNA结合ChIP-seq数据的软件GeneTrack。

5. 江赐忠教授的研究结果发表在Nature、Nat Rev Genet、Genome Research等国际著名学术刊物上，共发表20篇学术论文，并撰写专业书的一个章节。以第一作者发表的论文总影响因子超过103，以非第一作者发表的论文总影响因子超过59。其中，果蝇核小体图谱绘制与基因调控方面的研究成果以Article形式于2008年发表在Nature上，目前单篇引用已超过252次。同年在Genome Research上发表的关于酵母核小体与基因调控方面的研究报道，已被引用211次。2009年在Nature Reviews Genetics上发表了一篇关于核小体定位和基因调控的综述文章（作为该期封面文章），已被引用223次。2009年10月在Genome Biology上发表的酵母核小体系统参考图被评为“highly accessed”的文章。值得一提的是，发表在Nature和Genome Research上的两篇文章同时被国际著名学术期刊Nature Methods以“Research Highlights”形式进行报道；发表在Nature Reviews Genetics上的文章被国际著名学术期刊Nature Reviews Genetics以“Research Highlights”形式进行报道。 

代表性论文：

1.Liu W, Cui X, Zhang Y, Gu L, He Y, Li J, Gao S,3 Gao R#, Jiang C#. (2024) Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development. Genom Proteom Bioinf. 2024. Jul 2; 22(2):qzad001. doi: 10.1093/gpbjnl/qzad001. 

2.Gao R*#, Yang G*, Wang M*, Xiao J*, Yi S, Huang Y, Guo Z, Kang Y, Fu Q, Wang M, Xu B, Shen S, Zhu Q, Liu M, Wang L, Cui X, Yi S, Kou X, Zhao Y, Gu L, Wang H, Gao S#, Jiang C#, Chen J#. (2024) Defining a TFAP2C-centered transcription factor network during murine peri-implantation. Dev Cell. 2024 May 6; 59(9):1146-1158.e6. doi: 10.1016/j.devcel.2024.03.015. Epub 2024 Apr 3. 

3.Zheng W*, Wang L*, He W, Hu X, Zhu Q, Gu L#, Jiang C#. (2023) Transcriptome profiles and chromatin states in mouse androgenetic haploid embryonic stem cells. Cell Prolif. 2023 Sep; 56(9):e13436. doi: 10.1111/cpr.13436. Epub 2023 Mar 1. 

4.Wu C*, Liu Y*, Liu W*, Zou T*, Lu S, Zhu C, He L, Chen J, Fang L, Zou L, Wang P, Fan L, Wang H, You H, Chen J#, Fang JY#, Jiang C#, Shi Y#. (2023) NNMT-DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition. Adv Sci (Weinh). 2022 Nov 16;10(1):e2202642. doi: 10.1002/advs.202202642. 

5.Wang, Mingzhu, Zhao, Kun, Liu, Meng, Wang, Mengting, Qiao, Zhibin, ..., Jiang, Cizhong, Gao, Shaorong, Chen, Jiayu (2022). BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding. PROTEIN & CELL.

6.Bai, Dandan, Sun, Jin, Chen, Chuan, Jia, Yanping, Li, Yanhe, ..., Wang, Hong, Wang, Zheng, Chen, Miaoxin (2022). Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos. CELL REPORTS.

7.Liu M*, Guo G*, Qian P*, Mu J*, Lu B, He X, Fan Y, Shang X, Yang G, Shen S, Liu W, Wang L, Gu L, Mu Q, Yu X, Zhao Y, Culleton R, Cao J, Jiang L, Wellems TE#, Yuan J#, Jiang C#, Zhang Q#. (2022) 5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2110713119. doi: 10.1073/pnas.2110713119.

8.Lu, Binbin, Liu, Meng, Gu, Liang, Li, Ying, Shen, Shijun, ..., Culleton, Richard, Wei, Gang, Zhang, Qingfeng (2021). The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum.. mBio.

9.Liu, Wenju, Shen, Junwei, Li, Yanfei, Wu, Jiawen, Luo, Xiaoli, ..., Zhang, Xiaobai, Jiang, Cizhong, Li, Jue (2021). Pyroptosis inhibition improves the symptom of acute myocardial infarction. CELL DEATH & DISEASE.

10.Zhao, Yuemeng, Wang, Fei, Wang, Changhong, Zhang, Xiaobai, Jiang, Cizhong, Ding, Feng, Shen, Li, Zhang, Qingfeng (2021). Optimization of CRISPR/Cas System for Improving Genome Editing Efficiency in Plasmodium falciparum. FRONTIERS IN MICROBIOLOGY.

11.Xu, Xiangjie, Du, Yanhua, Ma, Lin, Zhang, Shuwei, Shi, Lei, ..., Jiang, Cizhong, Liu, Ling, Zhang, Xiaoqing (2021). Mapping germ-layer specification preventing genes in hPSCs via genome-scale CRISPR screening. ISCIENCE.

12.Chen, Wen, Liu, Nana, Shen, Shijun, Zhu, Wei, Qiao, Jing, ..., Xi, Jiajie, Jiang, Cizhong, Kang, Jiuhong (2021). Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring. CELL REPORTS.

13.Yang G*, Zhang L*, Liu W*, Qiao Z, Shen S, Zhu Q, Gao R, Wang M, Wang M, Li C, Liu M, Sun J, Wang L, Liu W, Cui X, Zhao K, Zang R, Chen M, Liang Z, Wang L, Kou X, Zhao Y, Wang H, Wang Y, Gao S#, Chen J#, Jiang C#. (2021) Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer. Cell Stem Cell. 2021 Jan 7; 28(1):150-163. doi: 10.1016/j.stem.2020.09.006.  

14.Sun, Jin, Zheng, Weisheng, Liu, Wenqiang, Kou, Xiaochen, Zhao, Yanhong, ..., Gao, Rui, Gao, Shaorong, Jiang, Cizhong (2021). Differential Transcriptomes and Methylomes of Trophoblast Stem Cells From Naturally-Fertilized and Somatic Cell Nuclear-Transferred Embryos. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.

15.Ma, Lin, Du, Yanhua, Hui, Yi, Li, Nan, Fan, Beibei, ..., Jiang, Cizhong, Liu, Ling, Zhang, Xiaoqing (2021). Developmental programming and lineage branching of early human telencephalon. EMBO JOURNAL.

16.Lu, Ping, Yang, Guang, Jiang, Lichun, He, Wen, Wu, Wanwan, ..., Jiang, Cizhong, Fan, Guoping, Zhu, Xianmin (2021). Characterizing disease progression of nonalcoholic steatohepatitis in Leptin-deficient rats by integrated transcriptome analysis. EXPERIMENTAL BIOLOGY AND MEDICINE.

17.Nagy, Zsuzsanna, Seneviratne, Janith A., Kanikevich, Maxwell, Chang, William, Mayoh, Chelsea, ..., Parker, Michael W., Cheung, Belamy B., Marshall, Glenn M. (2021). An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability. NATURE COMMUNICATIONS.

18.Shang, Xiaomin, Shen, Shijun, Tang, Jianxia, He, Xiaoqin, Zhao, Yuemeng, ..., Cao, Jun, Gu, Liang, Zhang, Qingfeng (2021). A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum. NUCLEIC ACIDS RESEARCH.

19.Guo, Gangqiang, Chen, Aqiong, Ye, Lele, Wang, Huijing, Chen, Zhiyuan, ..., Ding, Xiaokai, Xue, Xiangyang, Zhang, Huidi (2020). TCONS_00483150 as a novel diagnostic biomarker of systemic lupus erythematosus. EPIGENOMICS.

20.Fan, Yanting, Shen, Shijun, Wei, Guiying, Tang, Jianxia, Zhao, Yuemeng, ..., Cao, Jun, Jiang, Cizhong, Zhang, Qingfeng (2020). Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites. MBIO.

21.Fang, Yixuan, Gu, Yue, Li, Lei, Zhu, Lingjiang, Qian, Jiawei, ..., Xu, Youjia, Jiang, Cizhong, Wang, Jianrong (2020). Loss of Atg77 causes chaotic nucleosome assembly of mouse bone marrow CD11b(+)Ly6G(-) myeloid cells. AGING-US.

22.Bai, Dandan, Sun, Jin, Jia, Yanping, Yin, Jiqing, Zhang, Yalin, ..., Teng, Xiaoming, Liu, Wenqiang, Gao, Shaorong (2020). Genome transfer for the prevention of female infertility caused by maternal gene mutation. JOURNAL OF GENETICS AND GENOMICS.

23.Chen, Mo, Zhu, Qianshu, Li, Chong, Kou, Xiaochen, Zhao, Yanhong, ..., Liu, Xiaoyu, Jiang, Cizhong, Cd, Shaorong Gao (2020). Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos.Nat Commun. 2020 Apr 14; 11(1):1813. doi: 10.1038/s41467-020-15607-z.

24.Song, Ya-Xiang, Fan, Shu-Ling, Peng, Ai, Shen, Shijun, Cheng, Jia-Fen, ..., Jiang, Cizhong, Li, Xin-Hua, Liu, Jun-Yan (2020). A retrospective analysis reveals a predictor of survival for the patient with paraquat intoxication. CLINICA CHIMICA ACTA.

25.Zhang, Shiping, Guo, Xiaowei, Wu, Honggui, Sun, Ying, Ma, Xianjue, ..., Ho, Margaret S., Lv, Zhongwei, Xue, Lei (2019). Wingless modulates activator protein-1-mediated tumor invasion. ONCOGENE.

26.Liu, Meng, Lu, Binbin, Fan, Yanting, He, Xiaohui, Shen, Shijun, Jiang, Cizhong, Zhang, Qingfeng (2019). TRIBE Uncovers the Role of Dis3 in Shaping the Dynamic Transcriptome in Malaria Parasites. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.

27.Hu, Xinjie, Zheng, Weisheng, Zhu, Qianshu, Gu, Liang, Du, Yanhua, ..., Cheung, Belamy B., Qiu, Andong, Jiang, Cizhong (2019). Increase in DNA Damage by MYCN Knockdown Through Regulating Nucleosome Organization and Chromatin State in Neuroblastoma. FRONTIERS IN GENETICS.

28.Chen, Kaiming, Li, Dong, Li, Hongwen, Li, Bing, Wang, Ruiqin, ..., Jiang, Cizhong, Gu, Hua, Fang, Jianmin (2019). Improved recombinant protein production by regulation of transcription and protein transport in Chinese hamster ovary cells. BIOTECHNOLOGY LETTERS.

29.Chen, Xiaolong, Ye, Youqiong, Gu, Liang, Sun, Jin, Du, Yanhua, ..., Li, Wei, Zhang, Xiaobai, Jiang, Cizhong (2019). H3K27me3 Signal in the Cis Regulatory Elements Reveals the Differentiation Potential of Progenitors During Drosophila Neuroglial Development.Genom Proteom Bioinf. 2019 Jun; 17(3):297-304. doi: 10.1016/j.gpb.2018.12.009.

30.Li, Jin, Li, Yan, Li, Wei, Luo, Huaibing, Xi, Yanping, Jiang, Ci-zhong..., Peng, Shaoliang, Wu, Feizhen, Yu, Wenqiang (2019). Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks. GENOME RESEARCH.

31.Zhang, Qitong, Zhang, Qingquan, Jiang, Xue, Ye, Youqiong, Liao, Huimin, Jiang, Ci-zhong..., Chen, Yihan, Liang, Xingqun, Sun, Yunfu (2019). Collaborative ISL1/GATA3 interaction in controlling neuroblastoma oncogenic pathways overlapping with but distinct from MYCN. THERANOSTICS.

32.Tang, Wei, Guo, Ren, Shen, Shi-jun, Zheng, Yang, Lu, Yu-ting, ..., Cui, Xue, Jiang, Ci-zhong, Xie, Xin (2019). Chemical cocktails enable hepatic reprogramming of human urine-derived cells with a single transcription factor. ACTA PHARMACOLOGICA SINICA.

33.Nagy, Zsuzsanna, Kanikevichi, Maxwell, Koachi, Jessica, Mayoh, Chelsea, Carter, Daniel, ..., Norris, Murray, Cheung, Belamy, Marshall, Glenn (2019). Alyref is a novel binding partner and co-factor for MYCN-driven oncogenesis in neuroblastoma. CANCER RESEARCH.

34.Chen, Yu, Zhang, Haiping, Xu, Zhu, Tang, Huanyin, Geng, Anke, ..., Jiang, Ying, Gorbunova, Vera, Mao, Zhiyong (2019). A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. NUCLEIC ACIDS RESEARCH.

35.Zhang, Qingquan, Huang, Ru, Ye, Youqiong, Guo, Xiaoxia, Lu, Jun, ..., Jiang, Cizhong, Liang, Xingqun, Sun, Yunfu (2018). Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. CELL DEATH & DISEASE.

36.Zhu, Fugui, Zhu, Qianshu, Ye, Dan, Zhang, Qingquan, Yang, Yiwei, ..., Jiang, Cizhong, Shi, Weiyang, Kang, Jiuhong (2018). Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. NUCLEIC ACIDS RESEARCH.

37.He, Wenteng, Zhang, Xiaobai, Zhang, Yalin, Zheng, Weisheng, Xiong, Zeyu, ..., Jiang, Cizhong, Gao, Shaorong, Chen, Jiayu (2018). Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b. STEM CELL REPORTS.

38.Ping, Wangfang, Hu, Jian, Hu, Gongcheng, Song, Yawei, Xia, Qing, ..., Gong, Shixin, Jiang, Cizhong, Yao, Hongjie (2018). Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs. CELL DEATH & DISEASE.

39.Hu, Jian, Gu, Liang, Ye, Youqiong, Zheng, Meizhu, Xu, Zhu, ..., Zhang, Xiaobai, Weng, Zhiping, Jiang, Cizhong (2018). Dynamic placement of the linker histone H1 associated with nucleosome arrangement and gene transcription in early Drosophila embryonic development. CELL DEATH & DISEASE.

40.Fu, Shaliu, Wang, Qin, Moore, Jill E., Purcaro, Michael J., Pratt, Henry E., Jiang, Ci-zhong..., Kundaje, Anshul, Lu, Aiping, Weng, Zhiping (2018). Differential analysis of chromatin accessibility and histone modifications for predicting mouse developmental enhancers. NUCLEIC ACIDS RESEARCH.

41.Li, Jingyi, Shen, Shijun, Chen, Jiayu, Liu, Wenqiang, Li, Xiaocui, ..., Yin, Jiqing, Jiang, Cizhong, Gao, Shaorong (2018). Accurate annotation of accessible chromatin in mouse and human primordial germ cells. CELL RESEARCH 2018 Nov;28(11):1077-1089. doi: 10.1038/s41422-018-0096-5.

42.Zhang, Qingquan, Huang, Ru, Guo, Xiaoxia, Ye, Youqiong, Lu, Jun, ..., Jiang, Cizhong, Liang, Xingqun, Sun, Yunfu (2017). The temporal requirements for Isl1 in sympathetic neuron proliferation, differentiation and diversification. MECHANISMS OF DEVELOPMENT.

43.Fang, Yujiang, Liu, Zhongliang, Chen, Zhenyu, Xu, Xiangjie, Xiao, Mengtao, ..., Xiang, Bin, Liu, Ling, Zhang, Xiaoqing (2017). Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis. CELL RESEARCH.

44.Du, Yanhua, Liu, Zhenping, Cao, Xinkai, Chen, Xiaolong, Chen, Zhenyu, Zhang, Xiaobai, Zhang, Xiaoqing, Jiang, Cizhong (2017). Nucleosome eviction along with H3K9ac deposition enhances Sox2 binding during human neuroectodermal commitment. CELL DEATH AND DIFFERENTIATION. 2017 Jun; 24(6):1121-1131.

45.Chen, Kaiming, Li, Dong, Li, Hongwen, Li, Bing, Li, Jie, ..., Jiang, Cizhong, Gu, Hua, Fang, Jianmin (2017). Genetic analysis of heterogeneous sub-clones in recombinant Chinese hamster ovary cells. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.

46.Ye, Youqiong, Li, Min, Gu, Liang, Chen, Xiaolong, Shi, Jiejun, Zhang, Xiaobai, Jiang, Cizhong (2017). Chromatin remodeling during in vivo neural stem cells differentiating to neurons in early Drosophila embryos. CELL DEATH AND DIFFERENTIATION. 2017 Mar 7; 24(3):409-420.

47.Jiang Cizhong, Gao Shaorong (2017). Chromatin remodeling and its epigenetic regulatory mechanisms in cell fate transition. Chinese Bulletin of Life Sciences.

48.Tee, Andrew E., Liu, Bing, Song, Renhua, Li, Jinyan, Pasquier, Eddy, Jiang, Ci-zhong..., Fletcher, Jamie I., Dinger, Marcel E., Liu, Tao (2016). The long noncoding RNA MALAT1 promotes tumor-driven angiogenesis by up-regulating pro-angiogenic gene expression. ONCOTARGET.

49.Jin, Jiali, Liu, Jian, Chen, Cong, Liu, Zhenping, Jiang, Cong, Jiang, Ci-zhong..., Ge, Xin, Xie, Xin, Wang, Ping (2016). The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. NATURE COMMUNICATIONS.

50.Chi, Liankai, Fan, Beibei, Zhang, Kunshan, Du, Yanhua, Liu, Zhongliang,Jiang, Ci-zhong ..., Gao, Liang, Liu, Ling, Zhang, Xiaoqing (2016). Targeted Differentiation of Regional Ventral Neuroprogenitors and Related Neuronal Subtypes from Human Pluripotent Stem Cells. STEM CELL REPORTS.

51.Liu, Ling, Liu, Xu, Ren, Xudong, Tian, Yue, Chen, Zhenyu,Jiang, Ci-zhong ..., Jin, Guohua, Yang, Xiao, Zhang, Xiaoqing (2016). Smad2 and Smad3 have differential sensitivity in relaying TGF beta signaling and inversely regulate early lineage specification. SCIENTIFIC REPORTS.

52.Li, Dong, Shi, Jiejun, Du, Yanhua, Chen, Kaiming, Liu, Zhenping, ..., Gu, Hua, Jiang, Cizhong, Fang, Jianmin (2016). Profiling Analysis of Histone Modifications and Gene Expression in Lewis Lung Carcinoma Murine Cells Resistant to Anti-VEGF Treatment. PLOS ONE.

53.Wo, Da, Peng, Jinhui, Ren, Dan-ni, Qiu, Liman, Chen, Jinxiao, ..., Zou, Yunzeng, Qian, Qirong, Zhu, Weidong (2016). Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and beta-catenin. CIRCULATION.

54.Yang, Yuanyuan, Zhang, Xiaobai, Yi, Li, Hou, Zhenzhen, Chen, Jiayu, ..., Jiang, Cizhong, Wang, Yixuan, Gao, Shaorong (2016). Naive Induced Pluripotent Stem Cells Generated From beta-Thalassemia Fibroblasts Allow Efficient Gene Correction With CRISPR/Cas9 (vol 5, pg 8, 2016). STEM CELLS TRANSLATIONAL MEDICINE.

55.Gao, Hua, Chakraborty, Goutam, Zhang, Zhanguo, Akalay, Intissar, Gadiya, Mayur, Jiang, Ci-zhong..., Brogi, Edi, Leitinger, Birgit, Giancotti, Filippo G. (2016). Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling. CELL.

56.Lu, Ping, Chen, Xiaolong, Feng, Yun, Zeng, Qiao, Jiang, Cizhong, Zhu, Xianmin, Fan, Guoping, Xue, Zhigang (2016). Integrated transcriptome analysis of human iPS cells derived from a fragile X syndrome patient during neuronal differentiation. SCIENCE CHINA-LIFE SCIENCES.

57.Chen, Jun, Chen, Xiaolong, Li, Min, Liu, Xiaoyu, Gao, Yawei, ..., Wang, Hong, Jiang, Cizhong, Gao, Shaorong (2016). Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming. CELL REPORTS.

58.Li, Hongwen, Chen, Kaiming, Wang, Zhe, Li, Dong, Lin, Jiannan, ..., Jiang, Cizhong, Gu, Hua, Fang, Jianmin (2016). Genetic analysis of the clonal stability of Chinese hamster ovary cells for recombinant protein production. MOLECULAR BIOSYSTEMS.

59.Shi, Jiejun, He, Jiangtu, Lin, Jing, Sun, Xin, Sun, Fenyong, Ou, Chao, Jiang, Cizhong (2016). Distinct response of the hepatic transcriptome to Aflatoxin B-1 induced hepatocellular carcinogenesis and resistance in rats. SCIENTIFIC REPORTS.

60.Zhang, Shiping, Guo, Xiaowei, Chen, Changyan, Chen, Yujun, Li, Jikai, ..., Jiang, Cizhong, Li, Wenzhe, Xue, Lei (2016). dFoxO promotes Wingless signaling in Drosophila. SCIENTIFIC REPORTS.

61.Ye, Youqiong, Gu, Liang, Chen, Xiaolong, Shi, Jiejun, Zhang, Xiaobai, Jiang, Cizhong (2016). Chromatin remodeling during the in vivo glial differentiation in early Drosophila embryos. SCIENTIFIC REPORTS.

62.Liang, Xingqun, Zhang, Qingquan, Cattaneo, Paola, Zhuang, Shaowei, Gong, Xiaohui, Jiang, Ci-zhong..., Chen, Ju, Sun, Yunfu, Evans, Sylvia M. (2015). Transcription factor ISL1 is essential for pacemaker development and function. JOURNAL OF CLINICAL INVESTIGATION.

63.Men, Hewei, Zheng, Weisheng, Li, Junjie, Jiang, Cizhong, Cai, Jinzhen, Li, Jiang, Teng, Dahong (2015). The microRNA Signatures in Mouse Liver Ischemia Reperfusion Injury. TRANSPLANTATION.

64.Shen, Junwei, Jia, Wenwen, Yu, Yangyang, Chen, Jie, Cao, Xinkai, ..., Duan, Tao, Jiang, Cizhong, Kang, Jiuhong (2015). Pwp1 Is Required for the Differentiation Potential of Mouse Embryonic Stem Cells Through Regulating Stat3 Signaling.Stem Cells, 33(3): 661-73

65.Huang, Kaimeng, Zhang, Xiaobai, Shi, Jiejun, Yao, Mingze, Lin, Jiannan, ..., Jiang, Cizhong, Pei, Duanqing, Yao, Hongjie (2015). Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells. SCIENTIFIC REPORTS.

66.Fu, Yanbin, Huang, Chenwen, Xu, Xinxiu, Gu, Haifeng, Ye, Youqiong, Jiang, Cizhong, Qiu, Zilong, Xie, Xin (2015). Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails. CELL RESEARCH.

67.Li, Dong, Xie, Kun, Ding, Guitao, Li, Jie, Chen, Kaiming, ..., Qian, Jie, Jiang, Cizhong, Fang, Jianmin (2014). Tumor resistance to anti-VEGF therapy through up-regulation of VEGF-C expression.  Cancer Lett., 346(1): 45-52

68.Li, Min, Liu, Zhenping, Gu, Liang, Yin, Rong, Li, Huarong, Zhang, Xiaobai, Cao, Tongcheng, Jiang, Cizhong (2014). Toxic effects of decabromodiphenyl ether (BDE-209) on human embryonic kidney cells. FRONTIERS IN GENETICS.5: 118

69.Hu, Xinyang, Wu, Rongrong, Shehadeh, Lina A., Zhou, Qing, Jiang, Cizhong, ..., Yu, Hong, Webster, Keith A., Wang, Jian'an (2014). Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells.  BMC Genomics, 15(1): 303

70.Lin, Jiannan, Chen, Guangfeng, Gu, Liang, Shen, Yuefeng, Zheng, Meizhu, ..., Qiu, Yu, Liu, Xiaoqing, Jiang, Cizhong (2014). Phylogenetic affinity of tree shrews to Glires is attributed to fast evolution rate. Mol. Phylogenet. Evol., 71: 193-200

71.Tao, Yu, Zheng, Weisheng, Jiang, Yonghua, Ding, Guitao, Hou, Xinfeng, ..., Wang, Hong, Jiang, Cizhong, Gao, Shaorong (2014). Nucleosome organizations in induced pluripotent stem cells reprogrammed from somatic cells belonging to three different germ layers. BMC BIOLOGY. 12(1): 109

72.Yin, Rong, Gu, Liang, Li, Min, Jiang, Cizhong, Cao, Tongcheng, Zhang, Xiaobai (2014). Gene Expression Profiling Analysis of Bisphenol A-Induced Perturbation in Biological Processes in ER-Negative HEK293 Cells.  PLoS One., 9(6): e98635

73.Huang, Biao, Jiang, Cizhong, Zhang, Rongxin (2014). Epigenetics: the language of the cell?.Epigenomics, 6(1): 73-88

74.Shi, Jiejun, Zheng, Meizhu, Ye, Youqiong, Li, Min, Chen, Xiaolong, ..., Sun, Jin, Zhang, Xiaobai, Jiang, Cizhong (2014). Drosophila Brahma complex remodels nucleosome organizations in multiple aspects. Nucleic Acids Res., 42(15): 9730-9

75.Chen, Guangfeng, Shi, Xiujuan, Sun, Chen, Li, Min, Zhou, Qing, ..., Jiang, Cizhong, Ying, Ming, Liu, Xiaoqing (2013). VEGF-Mediated Proliferation of Human Adipose Tissue-Derived Stem Cells. PLoS One, 8(10): e73673

76.Zhang, Xiaobai, Shen, Yuefeng, Ding, Guitao, Tian, Yi, Liu, Zhenping, Li, Bing, Wang, Yun, Jiang, Cizhong (2013). TFPP: An SVM-Based Tool for Recognizing Flagellar Proteins in Trypanosoma brucei.  PLoS One, 8(1): e54032

77.Huang, Kaimeng, Jia, Jinping, Wu, Changwei, Yao, Mingze, Li, Min, Jiang, Ci-zhong..., Pei, Duanqing, Pan, Guangjin, Yao, Hongjie (2013). Ribosomal RNA Gene Transcription Mediated by the Master Genome Regulator Protein CCCTC-binding Factor (CTCF) Is Negatively Regulated by the Condensin Complex. JOURNAL OF BIOLOGICAL CHEMISTRY., 288(36): 26067-77

78.Dai, Xiuqin, Jiang, Weijian, Zhang, Qingquan, Xu, Lian, Geng, Peng, Jiang, Ci-zhong..., Sun, Yunfu, Chen, Ju, Liang, Xingqun (2013). Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC BIOLOGY.11(1): 107

79.Shi, Jiejun, Hu, Jian, Zhou, Qing, Du, Yanhua, Jiang, Cizhong (2013). PEpiD: A Prostate Epigenetic Database in Mammals. PLoS One, 8(5): e64289

80.Guo, Xudong, Liu, Qidong, Wang, Guiying, Zhu, Songcheng, Gao, Longfei, ..., Liu, Houqi, Jiang, Cizhong, Kang, Jiuhong (2013). microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming. CELL RESEARCH., 23(1): 142-56

81.Tang, Yitao, Dong, Shan, Cao, Xinkai, Zhou, Qing, Ding, Guitao, Jiang, Cizhong (2013). H2A.Z Nucleosome Positioning Has No Impact on Genetic Variation in Drosophila Genome.  PLoS One, 8(3): e58295

82.Chang GS, Noegel AA, Mavrich TN, Müller R, Tomsho L, Ward E, Felder M, Jiang C, Eichinger L, Glockner G, Schuster SC, Pugh BF. (2012) Unusual combinatorial involvement of poly-A/T tracts in organizing genes and chromatin in Dictyostelium. Genome Res, 22(6): 1098-106

83.Bao, Jianqiang, Li, Ding, Wang, Li, Wu, Jingwen, Hu, Yanqin, ..., Jiang, Cizhong, Yan, Wei, Xu, Chen (2012). MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway. Journal of Biological Chemistry, 287(26): 21686-98

84.Venters, Bryan J., Wachi, Shinichiro, Mavrich, Travis N., Andersen, Barbara E., Jena, Peony, ..., Jiang, Cizhong, Hemeryck-Walsh, Christine, Pugh, B. Franklin (2011). A Comprehensive Genomic Binding Map of Gene and Chromatin Regulatory Proteins in Saccharomyces. MOLECULAR CELL, 41(4): 480-92

85.Zhao, Zhongming, Jiang, Cizhong (2010). Features of Recent Codon Evolution: A Comparative Polymorphism-Fixation Study. Journal of Biomedicine and Biotechnology, 2010(2010): doi:10.1155/2010/202918

86.Jiang, Cizhong, Pugh, B. Franklin (2009). Nucleosome positioning and gene regulation: advances through genomics. Nature Reviews Genetics, 10(3): 161-72 Cover story

87.Koerber, R. Thomas, Rhee, Ho Sung, Jiang, Cizhong, Pugh, B. Franklin (2009). Interaction of Transcriptional Regulators with Specific Nucleosomes across the Saccharomyces Genome.  Mol Cell, 35(6): 889-902 

88.Jiang, Cizhong, Pugh, B. Franklin (2009). Identification and Nomenclature of the Consensus Nucleosomes Across the Yeast Genome. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS.

89.Jiang, Cizhong, Pugh, B. Franklin (2009). A compiled and systematic reference map of nucleosome positions across the Saccharomyces cerevisiae genome.  Genome Biology, 10: R109

90.Mavrich, Travis N., Jiang, Cizhong, Ioshikhes, Ilya P., Li, Xiaoyong, Venters, Bryan J., ..., Gilmour, David S., Albert, Istvan, Pugh, B. Franklin (2008). Nucleosome organization in the Drosophila genome. Nature, 453(7193): 358-62 Article

91.Lee, Chanhyo, Li, Xiaoyong, Hechmer, Aaron, Eisen, Michael, Biggin, Mark D., Jiang, Ci-zhong..., Li, Jian, Pugh, B. Franklin, Gilmour, David S. (2008). NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. MOLECULAR AND CELLULAR BIOLOGY, 28(10): 3290-300

92.Albert, Istvan, Wachi, Shinichiro, Jiang, Cizhong, Pugh, Franklin (2008). GeneTrack - a genomic data processing and visualization framework.  Bioinformatics, 24(10): 1305-6

93.Kuo, Po-Hsiu, Kalsi, Gursharan, Prescott, Carol A., Hodgkinson, Colin A., Goldman, David, Jiang, Ci-zhong..., Walsh, Dermot, Kendler, Kenneth S., Riley, Brien P. (2008). Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. Alcoholism: Clinical and Experimental Research, 32(5): 785-95

94.Mavrich, Travis N., Ioshikhes, Ilya P., Venters, Bryan J., Jiang, Cizhong, Tomsho, Lynn P., ..., Schuster, Stephan C., Albert, Istvan, Pugh, B. Franklin (2008). A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome. Genome Research, 18(7): 1073-1083

95.Zhao, Zhongming, Jiang, Cizhong (2007). Methylation-dependent transition rates are dependent on local sequence lengths and genomic regions. MOLECULAR BIOLOGY AND EVOLUTION, 24(1): 23-5

96.Jiang, Cizhong, Han, Leng, Su, Bing, Li, Wen-Hsiung, Zhao, Zhongming (2007). Features and trend of loss of promoter-associated CpG islands in the human and mouse genomes. MOLECULAR BIOLOGY AND EVOLUTION., 24(9): 1991-2000   

97.Zhao, Z and Jiang, C (2007) Investigation of the CpG Effect in Mammalian Genomes - Chapter I in: Kobayashi TB editor. DNA Methylation Research Trends, Pg 1-24. Nova Science Publishers, Inc., Hauppauge, NY (ISBN 1-60021-721-4)

98.Jiang, C, Xuan, Z, Zhao, F, and Zhang, MQ (2007) TRED: a Transcriptional Regulatory Element Database, new entries and other development. Nucleic Acids Res., 35: D137-D140

99.Jiang, Cizhong, Zhao, Zhongming (2006). Mutational spectrum in the recent human genome inferred by single nucleotide polymorphisms. Genomics, 88(5): 527-34

100.Jiang, Cizhong, Zhao, Zhongming (2006). Directionality of point mutation and 5-methylcytosine deamination rates in the chimpanzee genome. BMC Genomics, 7(1): 316

101.Boddu, J, Jiang, CH, Sangar, V, Olson, T, Peterson, T, Chopra, S (2006). Comparative structural and functional characterization of sorghum and maize duplications containing orthologous myb transcription regulators of 3-deoxyflavonoid biosynthesis. PLANT MOLECULAR BIOLOGY, 60(2): 185-99

102.Seo, Daekwan, Jiang, Cizhong, Zhao, Zhongming (2006). A novel statistical method to estimate the effective SNP size in vertebrate genomes and categorized genomic regions. BMC Genomics, 7(1): 329

103.Jiang, CH, Gu, JY, Chopra, S, Gu, X, Peterson, T (2004). Ordered origin of the typical two- and three-repeat Myb genes. Gene, 326: 13-22

104.Jiang, CZ, Gu, X, Peterson, T (2004). Identification of conserved gene structures and carboxy-terminal motifs in the Myb gene family of Arabidopsis and Oryza sativa L. ssp indica. Genome Biology, 5(7): R46

105.Jiang, CZ, Song, WQ, Li, XL, Chen, RY (1998). Studies on microdissection and microcloning of the rye chromosome 1R. Acta Botanica Sinica, 40(11): 988-993 

荣誉奖励：

资料更新中……

 

学术交流：

1. 参加了2009年的The 16th Conversation for Journal of Biomolecular Structure and Dynamics国际会议。

2. 参加了2010年的The 8th International Bioinformatics Workshop国际会议。

3. 参加了2010年与2012年冷泉港亚洲会议Epigenetics, Chromatin & Transcription国际会议。

4. 参加了2012年的International Workshop and Summer School on Crops国际会议。

5. 同时也邀请了时为北卡罗来纳州大学教堂山分校(University of North Carolina at Chapel Hill)的Jason Lieb教授等国内外知名学者来校访问交流。