宁君——农药研究专家宁君——中国农业科学院植物保护研究所研究员

科学研究：

承担科研项目情况：

1.主持中国农科院一级人才启动项目一项；

2.参加农业部盲椿象行业专项一项；

3.参加农药研究方面973项目两项；

4.参加农药研究方面863项目一项。

研究成果：

1. 首次提出利用簇合效应（cluster effect）原理创制新农药的研究方法，已在农药靶标酶的分子水平上发现簇合分子活性比其母体分子大几百倍至几百万倍。相关论文发表在国际学术期刊J. Pestic. Sci.和 Pesticide Biochemistry and Physiology上，并陆续将有更高水平的论文发表。这一理论很有可能成新农药创制的一种重要方法。

2. 设计合成了一系列新的嘧啶类除草剂，已申请中国发明专利，其除草活性大约是目前主要除草剂异丙甲草胺的5-8倍。目前正在进行田间试验。

3. 首次完成香菇多糖核心结构寡糖的合成及活性测定，发现其生物活性和香菇多糖相当。验证了多糖的活性取决于其中寡糖片段的假想，而不是多糖的高级结构-如三螺旋构型，形成了具有独立知识产权的原始发明专利。以此研究结果所发表的论文获得国际 Bioorganic & Medicinal Chemistry Most Cited Paper 2003-2006 Award。

论文专著：

发表论文：

1 Hongju Ma, Dewen Qiu, Xiangdong Mei, Jun Ning*, Qianfei Zhao, Yonghong Li. Efficient synthesis of allose-containing analogue of the phytoalexin-elicitor glucohexaose and its dodecyl glycoside. SYNTHESIS. 2009, 2, 199-204.

2 Qianfei Zhao，Guoquan Yang , Xiangdong Mei, Jun Ning* . Novel acetylcholinesterase inhibitors: synthesis and activity of phthalimide alkyloxylphenyl N,N-dimethylcarbamate derivatives. Pesticide Biochemistry and Physiology, 2009, （in press）.

3 Guoquan Yang, Qianfei Zhao, Yonghong Li, Huizhu Yuan, Xiangdong Mei, and Jun Ning*. Synthesis of bivalent organophosphorus compounds as acetylcholinesterase inhibitors. Org. Prep. Proced. Int., 2008, 40 (5), 499-504.

4 Qianfei ZHAO, Guoquan YANG, Xiangdong MEI, Huizhu YUAN and Jun Ning*. Design of novel carbamate acetylcholinesterase inhibitors based on the multiple binding sites of acetylcholinesterase. J. Pestic. Sci., 2008, 33(4), 371-375.

5 Linsen Heng , Qianfei Zhao, Xiangdong Mei, Haibin Lv , Xiaohui Jiang, and Jun Ning. Synthesis of Alkyl β-D- Glcp- (1→ 3)- [β-D-Glcp- (1→6)]-β-D- Glcp-(1→6)-β-D-glucopyranosides with Anti-tumor Activity. LOC.(Letters in Organic Chemistry). 2007, 4 (2),142-145 .

6 YI, Yue-Tao; ZHAO, Qian-Fei; NING, Jun*. Highly Efficient Regio- and Stereoselective Synthesis of beta -(1-6)- Branched beta-(1-3)-Linked Glucohexaose and Its Analogue. Chinese J Chem . 2007, 25, 385—389.

7.Jun. Ning, F. Kong，1997，Synthesis and glycosidic coupling reaction of substituted 2,6-dioxabicyclo[3.1.0]hexanes. J. Carbohydr. Chem., 16，311-325.

8 FU, Ming-Kun, WU, Xian, NING, Jun*, LI, Jian-Zhong*. 2005, Solid Phase Synthesis of 4″-epi-Methylamino-4″- deoxyavermectin B1 Benzoate. Chinese J. of Chem., 23(7) , 901-904 .

9 Guohua Zhang, Mingkun Fu and Jun Ning*. 2005, An efficient and concise synthesis of a β-(1→6)-linked D- galactofuranosyl hexasaccharide. Carbohydr. Res., 340, 1, 155-159

10 Guohua Zhang, Mingkun Fu, Jun Ning*, 2005 First synthesis of D-galacto Bifidobacterium catenulatum YIT 4016. Tetrahedron:Asymmstry. 16, 3, 733-738 .

11 Guohua Zhang, Mingkun Fu, Jun Ning*, 2005, Synthesis of galactose-containing analogues of (1→6)-branched (1→3)- glucohexaose and its lauryl glycoside. Carbohydr. Res., 340, 4, 21 March 2005, Pages 597-602.

12 Xiangdong Mei, Jun Ning*. An Efficient Synthesis of a Dimer of the Tetrasaccharide Present in Motif B of the Mycobacterium tuberculosis Cell Wall. Synlett. 2005, Issue 15, 2267─2272.

13 Mingkun Fu, Guohua Zhang and Jun Ning*. 2005, First synthesis of the immunodominant β-galactofuranose-containing tetrasaccharide present in the cell wall of Aspergillus fumigatus. Carbohydr. Res., 340, 1, 25-30.

14  Jun. Ning, F. Kong，1997，Synthesis and coupling reaction of 1,2-anhydro-3,5-di-O-benzyl-L-ribofuranose. Carbohydr. Res., 300, 355-360.

15 Xiangdong Mei, Linsen Heng, Mingkun Fu, Zhimin Li, Jun Ning*. Synthesis of b-D-glcp-(1®3)-[b-D-glcp-(1®6)]-b-D-glcp -(1®3)-b-D-glcp-(1®6)-[b-D-galp-(1®4)-b-D-glcp-(1®3)]-b-D-GlcpOLauryl, an oligosaccharide with antitumor activity. Carbohydr Res. 2005, 340 (15), 2345─2351.

16 Linsen Heng, Xiangdong Mei*, Zhe Yao, Jun Ning*. Synthesis of a Tetrasaccharide Present in Motif B of the Mycobacterium tuberculosis Cell Wall. LOC.(Letters in Organic Chemistry) 2005, 2(8), 749─751.

17 Feng, JJ; Li, JQ; Liu XL; Ning, J; Kong, FZ, Chemical journal of Chinese universities-chinese. 2004, 25: 2273

18 Jun Ning*, Yuetao Yi, Zhe Yao, 2003, An Efficient Method for the Synthesis of 2,6-Branched Galacto-oligosaccharides and itsApplications to the Synthesis of Three tetrasaccharides and a Hexasaccharide Related to the Arabinogalactans. Synlett.14, 2208-2212.

19 Zicheng Wu, Jun Ning, Fanzuo Kong，2003, Synthesis of b-(1®6)-branched (1®3)-glucododecaose and - glucopentadecaose with alternate b- and a-bonds in the backbone, Carbohydr. Res. 338, 2203-2212.

20 Zicheng Wu, Jun Ning, Fanzuo Kong，2003, Synthesis of b-(1®6)-Branched (1®3)-Glucononaoside with Alternate b- and a-Bonds in the Backbone. Chinese Journal of Chemistry. 21, 1655-1660.

21 Jun Ning,* Wenhui Zhang, Yuetao Yi, Guangbin Yang, Zhikui Wu, Jie Yi, Fanzuo Kong, 2003, Synthesis of b-(1®6)- Branched b-(1®3) Glucohexaose and Its Analogues Containing an a-(1®3) Linked Bond with Antitumor Activity. Bioorg. Med. Chem. 11/10, 2193-2203..

22 Hairong Wang, Zhaolong Li, Jun Ning* and Fanzuo Kong, 2003, A new and practical procedure for the preparation of the glucohexatose phytoalexin elicitor. Chin. J. Chem. 21，944-949.

23 Jianjun Zhang, Jun Ning, Fanzuo Kong, 2003, Efficient synthesis of a heptasaccharide, the repeating unit of the O-chain lipopolysaccharide produced by Xanthomonas campestris strain 642. Carbohydr. Res. 338, 1023-1031.

24 Hairong Wang, Guohua Zhang, Jun Ning,* 2003, First synthesis of b-D-Galf-(1®3)-D-Galp ¾ the repeat unit of the backbone structure of the O-side-chain polysaccharide present in the lipopolysaccharide (LPS) of the genus Klebsiella. Carbohydr. Res. 338, 1033-1037.

25 Ying Xing, Jun Ning*, 2003, First syntheses of D-mannose penta- and decasaccharides, the repeating unit and its dimmer of the cell-wall mannan of Candida kefyr IFO 0586. Tetrahedron: Asymmetry. 14/10, 1275-1283.

26 Yuetao Yi, Jun Ning,* Fanzuo Kong, 2003, Highly Efficient Syntheses of the Phytoalexin-Elicitor Active b-(1®3)- Branched b-(1®6) Heptaglucose and Its Dodecyl Glycoside. Synthesis. 4, 491-496.

27 Hairong Wang, Jun Ning,* 2003, A One-pot Strategy for Synthesis of 5-O-(a-D-Arabinofuranosyl)-6-O-(b-D- galactofuranosyl)-D-galactofuranose Present in Motif E of the Mycobacterium tuberculosis Cell Wall. J. Org. Chem. 68, 2521-2524.

28 Ying Zeng, Jun Ning, Fanzuo Kong, 2003, Remote control of a- or b-stereoselectivity in (1®3)-glucosylation in the presence of C2 ester capable of neighboring group participation. Carbohydr. Res. 338, 307-311.

29 Jun Ning, Fanzuo Kong, Bangmao Lin, Huide Lei, 2003 Large Scale Preparation of the Phytoalexin Elicitor Glucohexatose and Its Application as Green Pesticide. J. Agr. Food Chem. 51, 987-991.

30 Youlin Zeng, Jianjun Zhang, Jun Ning, F. Kong, 2003, Synthesis of a mannose heptasaccharide existing in baker’s yeast Saccharomyces cerevisiae X2180-1A wild-type strain. Carbohydr. Res., 338, 5-9.

31 Jun Ning*, Ying Xing, F. Kong, 2003, A facile and practical synthesis of Shimofuridin analogue. Carbohydr. Res., 338, 55-60.

32 Ying Zeng, Jun Ning*, F. Kong, 2002, Facile and effective synthesis of glucopyranosyl oligosaccharides with alternative (1®3)-a- and -b-linkages in the presence of C2 ester capable of neighboring group participation. Chin. J. Chem. 20, 1142-1144.

33 Ying Zeng, Wenhui Zhang, Jun Ning*, F. Kong, 2002, Synthesis of two isomeric pentasaccharides, the possible repeating unit of the b-glucan from the micro fungus Epicoccum nigrum Ehrenb. ex Schlecht. Carbohydr. Res.,337, 2383-91.

34 Jun. Ning*, Hairong Wang, Yuetao Yi, 2002, A Simple approach to 3,6-branched galacto oligosaccharides and its applications to the syntheses of a tetrasaccharide and a hexasaccharide related to the arabinogalactans (AGs). Tetrahedron lett. 43, 7349-7352.

35 Jun. Ning*, Y. Yi, F. Kong, 2002, A general strategy for the synthesis of 3,6-branched glucooligosacchrides: facile synthesis of the phytoalexin elicitor oligosaccharides. Tetrahedron lett.43, 5545-5549.

36 Jun. Ning, L. Heng, F. Kong, 2002, Synthesis a mannooctaose repeating unit of the cell wall mannan. Carbohydr. Res. 337, 1159-1166.

37 Y. Zeng, Jun. Ning*, F. Kong, 2002, Pure alpha-linked products can be generated using gucosyl trichloroacetimidate with C2 ester capable of neighboring group participation. Tetrahedron Lett.43, 3729-3733.

38 L. Heng, Jun. Ning, F. Kong, 2002, Synthesis of chiral isosquramide containing amino acid. Synth. Commun. 32, 1219- 1226.

39 Jun. Ning, L. Heng, F. Kong，2002， Facile Syntheses of D-Manno-hexa- and Nonasaccharides: a Dimer and a Trimer of the Trisaccharide Repeating Unit of the Cell-Wall Mannans of Epidermophton floccosum, Trychophyton mentagrophytes, Microsporum canis and Related Species of Microsporum. Tetrahedron Lett. 43，673-5.

40 L. Heng, Jun. Ning, F. Kong，2001，Synthesis of a mannotetraose –the repeating unit of the cell-wall mannans of Microsporum gypseum and related species of Trychophyton J. Carbohydr. Chem.,20，285-296。

41 L. Heng, Jun. Ning, F. Kong，2001， Facile synthesis of a comb-like mannohexaose: a trimer epitope of the cell-wall mannans of Aphanoascus mephitalus and related species. Carbohydr.Res., 331，431－437。

42 Jun. Ning, F. Kong*，2001， Synthesis and glycosidic coupling reactions and glycosidic coupling reaction of partially acylated 1,2-anhydrosugar benzyl ethers. Carbohydr.Res., 330，165-175.

43 Jun. Ning, F. Kong，2000，A facile synthesis of 1-(5’-O-acetyl-3’-O-benzyl-b-D-xylofuranosyl)thymidine: a potentially viable intermediate for the preparation of the anti-AIDS drugs, AZT and D4T. Carbohydr.Res., 326，235-239.

44 Jun. Ning, F. Kong，1999，Facile syntheses of a hexasaccharide and a nonasaccharide related to the cell wall D-mannan of yeast Candida Albicans。 Tetrahedron Lett., 40 ，1357-60.

45 Jun. Ning, F. Kong，1998，Chin. Sci. Bull., 43702-3

46 J. Ning, F. Kong，1998，Synthesis of partially acetylated 1,2-anhydro sugar benzyl ethers. J. Carbohydr. Chem., 17， 993-7.

47 Jun. Ning*, F. Kong D.Li, Y. Du, 1998，Preparation of monodisperse agglomerated pellicular anion-exchange resins compatible with high-performance liquid chromatography solvents for ion chromatography. J. Chromatography A, 793， 193-7.

48 Jun. Ning, F. Kong，1997，A facile synthesis of Shimofuridin analogue. Bioorg. Med. Chem. Lett., 7， 2941-44.

49 除草剂的主要作用靶标及作用机理 宋倩; 梅向东; 宁君; 袁会珠; 农药 2008-10-10  

50 新烟碱类簇合物的合成及其生物活性 杨国权; 赵前飞; 袁会珠; 梅向东; 宁君; 农药学学报 2008-09-15

51 纳米颗粒混悬剂——新兴的农药制剂 宋倩; 梅向东; 曹坳程; 黄啟良; 王忠跃; 宁君; 现代农药 2009-04-10

52 生物电子等排原理在农药与医药开发中的应用 宋倩; 梅向东; 宁君; 河北工业科技 2009-03-15

53 新农药呋喃虫酰肼在四种土壤中吸附行为的研究 张玉超; 梅向东; 胡继业; 宁君; 现代农药 2009-06-10

54 咪唑啉酮类簇合物的合成及其除草活性(英文) 马洪菊; 曹坳程; 梅向东; 宁君; 李永红; 农药学学报 2009-06-15

55 乳液聚合法制备阿维菌素微胶囊及其生物活性研究 宋倩; 梅向东; 黄啟良; 王忠跃; 宁君; 农药学学报 2009-09-15

56 几种葡聚寡糖激发子及其衍生物生物活性的比较 邱驰; 李宝聚; 范海延; 石延霞; 宁君 植物病理学报 2004-09-20

57 植物系统获得性抗病诱导剂葡聚六糖诱导蔬菜抗病性的研究 李宝聚; 范海延; 赵哀枚; 王福建; 潘凌; 宁君; 孔繁祚 中国农业科学 2001-12-20

58 盲蝽科害虫性信息素研究进展 张涛; 杨代斌; 李永红; 袁会珠; 宁君; 梅向东; 植物保护科技创新与发展——中国植物保护学会2008年学术年会论文集 2008-10-01

59 可控缓释纳米农药制剂及其研究进展 宋倩; 黄啟良; 袁会珠; 宁君; 王忠跃; 梅向东; 植物保护科技创新与发展——中国植物保护学会2008年学术年会论文集 2008-10-01

60 复合可控缓释植物抗病诱导剂 马洪菊; 宁君; 王忠跃; 梅向东; 植物保护科技创新与发展——中国植物保护学会2008年学术年会论文集 2008-10-01

61 1,3,4-噻二唑簇合物的合成 宋倩; 梅向东; 宁君; 合成化学 2008-12-20

荣誉奖励：

1.1998年获中国科学院院长优秀奖；

2.2001年获中科院青年科学家奖；

3.2002年获辽宁省科技进步一等奖；

4.获得国际Bioorganic & Medicinal Chemistry Most Cited Paper 2003-2006 Award。

资料更新中……

发明专利：

1 具有除草活性的嘧啶水杨酸簇合分子 宁君; 梅向东; 赵前飞; 衣悦涛; 马洪菊; 杨国权 中国农业科学院植物保护研究所 2007-08-01

2 具有显著生物活性的氟代烯硫基、氟代烯氨基均三嗪衍生物 宁君; 陈作红; 赵前飞; 梅向东; 马洪菊; 杨国权; 张涛; 李永红 中国农业科学院植物保护研究所 2007-12 -26

3 具有明显生物活性的新型嘧啶衍生物 宁君; 陈作红; 张涛; 梅向东; 张建军; 赵前飞; 李永红 ; 马洪菊; 杨国权; 宋倩 中国农业科学院植物保护研究所 2008-02-27

4 阿维菌素类药物缓释纳米微球制剂的制备及其应用 宁君; 梅向东; 黄啟良; 赵前飞; 李永红; 马洪菊; 杨国权; 宋倩; 张涛 中国农业科学院植物保护研究所 2008-06-11

5 利用簇合效应原理创制和发现新农药的方法 宁君; 梅向东; 衣悦涛 中国农业科学院植物保护研究所 2006-10-25

6 具有杀虫活性的氨基甲酸酯类化合物簇合分子 宁君; 衣悦涛; 赵前飞; 梅向东; 马洪菊; 杨国权 中国农业科学院植物保护研究所 2007-06 -27

7 烯酰胺类簇合物的制备与应用 宁君; 杨国权; 赵前飞; 梅向东; 衣悦涛; 马洪菊 中国农业科学院植物保护研究所 2007-06-27

8 具有显著生物活性的三唑类化合物低聚合体 赵前飞; 宁君; 杨国权; 马洪菊; 梅向东; 衣悦涛 中国农业科学院植物保护研究所 2007-07-11

9 新型三氮杂苯酮类簇合物的制备及其应用 宁君; 马洪菊; 梅向东; 赵前飞; 衣悦涛; 杨国权 中国农业科学院植物保护研究所 2007-07-11

10 除虫脲可控缓释纳米颗粒的制备方法及其应用 梅向东; 宋倩; 袁会珠; 宁君; 赵前飞; 马洪菊; 杨国权; 张涛; 李永红 中国农业科学院植物保护研究所 2008-08-27

11 武夷菌素可控缓释纳米微球的制备及其应用 梅向东; 宋倩; 张克诚; 黄啟良; 宁君; 赵前飞; 马洪菊 ; 张涛; 李永红 中国农业科学院植物保护研究所 2009-01-14

12 植物激活蛋白可控缓释纳米微球的制备及其应用 徐军; 宁君; 宋倩; 曾红梅; 梅向东; 黄啟良; 赵前飞; 马洪菊; 张涛; 李永红 中国农业科学院植物保护研究所 2009-01-14

13 具有显著除草活性的磺酰基异恶唑衍生物 宁君; 陈作红; 赵前飞; 梅向东; 宋倩; 马洪菊; 杨国权; 张涛; 李永红 中国农业科学院植物保护研究所 2009-02-11