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李奇渊厦门大学健康医疗大数据研究院副院长

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李奇渊博士，国家高层次青年人才、福建省高层次人才、厦门大学南强青拔人才，厦门大学医学院教授、博士生导师，厦门大学健康医疗大数据国家研究院副院长。主要致力于计算医学、生物信息学等方面研究。兼任福建省生物信息学学会副会长、中国优生优育协会专业委员会副主任、中国医疗器械行业协会医疗器械物联网管理专业委员会智慧医疗专家组副组长、厦门大学医学院医学伦理委员会委员、中国卫生信息与健康医疗大数据学会三医联动健康保障分会常务理事、数字福建健康医疗大数据研究所副所长、中国细胞生物学学会功能基因组信息学与系统生物学分会委员。Frontiers in Genetics、Frontiers in Pediatrics杂志专题编辑。

在完成丹麦科技大学博士学位后，李奇渊博士在美国哈佛大学癌症中心开展了深入的博士后研究，期间他以共同第一作者，在国际顶尖学术期刊Nature Medicine上发表了重要研究成果。自2012年入职厦门大学医学院后，李奇渊教授已在包括Cell，Nature Communications，Cancer Research，Genome Medicine，eLife，EBiomedicine，Briefings in Bioinformatics等国际知名期刊上，以第一作者或通讯作者的身份发表发表了SCI论文59篇，H-index 36，论文累计他引10884次。目前主持的在研项目有2项国家自然科学基金面上项目、7项市级研究项目，参与多项国家级、省部级、市级研发项目，总支持经费2千万元。

教育及工作经历：

1996.09-2000.07，华东理工大学本科；

2000.09-2003.07，厦门大学细胞生物学硕士；

2004.08-2006.04，丹麦科技大学生物信息学硕士；

2006.07-2011.01，丹麦科技大学系统生物学博士。

2010.03-2012.03，哈佛大学癌症中心博士后；

2012.03-2017.10，厦门大学医学院副教授；

2017.11- 至今厦门大学医学院，教授；

2015~至今挂职担任厦门大学附属第一医院儿内科科研副主任，开展儿科遗传性缺陷筛查和科研支撑工作；

2016~至今挂职担任卫计委健康医疗大数据管理中心主任。负责建立人口健康大数据应用开放平台，支持儿科智能化研究。

2018.9至今厦门大学健康医疗大数据国家研究院副院长

社会任职：

2024年-至今厦门外国语学校瑞景分校科学副校长

2024年-至今厦门大学附属妇女儿童医院儿科双聘主任

2018年-2024年厦门大学附属第一医院儿科双聘主任

2023年-至今中国细胞生物学学会功能基因组信息学与系统生物学分会委员

2021年-至今福建省生物信息学学会副秘书长，理事

2021年-至今中国医疗保健国际交流促进会—健康数据与数字医学分会委员

2020年-至今中国优生优育协会妇科肿瘤专业委员会副主任委员

2019年-至今厦门大学医学院医学伦理委员会委员

2018年-至今数字福建健康医疗大数据研究所副所长

2018年-至今厦门大学附属第一医院血液学系兼职教授

2017年-至今厦门大学健康医疗大数据国家研究院副院长

已申请美国的专利：

1. 实体肿瘤的临床预后基因标签, 美国专利申请号 No. 61/175,781

中国发明公开：

[1]郭金涛, 李奇渊, 钟桃玲, 周裕林. 肿瘤体细胞突变标签提取方法及装置[P]. 福建省: CN117912556A, 2024-04-19.

[2]郭金涛, 李奇渊, 钟桃玲, 周裕林. 肿瘤体细胞突变标签倾向分数计算方法及装置[P]. 福建省: CN117912555A, 2024-04-19.

[3]李奇渊, 秦青青, 周颖, 郭金涛. 一种乳腺癌肿瘤特异性甲基化标签的鉴定方法、甲基化标签和探针位点[P]. 福建省: CN117721206A, 2024-03-19.

[4]陈龙彪, 李奇渊, 郑能鑫, 游建议, 梁涛, 王程. 医疗大数据可视化分析方法、介质、设备及系统[P]. 福建省: CN111242491A, 2020-06-05.

[5]刘青青, 谢文龙, 曾缘欢, 陈荣山, 李宇, 温恒斌, 肖辛野, 姚迅, 李奇渊, 李晓哲. 一种循环肿瘤DNA低频突变的检测方法[P]. 福建: CN108866174A, 2018-11-23.

[6]曾缘欢, 刘青青, 谢文龙, 陈荣山, 李宇, 温恒斌, 陈詹妮, 林程宏, 黄书鑫, 林俭耀, 姚迅, 李奇渊. 一种林奇综合征相关基因变异的检测方法[P]. 福建: CN108192971A, 2018-06-22.

[7]詹杜清, 杨文辉, 肖辛野, 谢文龙, 陈荣山, 颜夏菲, 姚迅, 李奇渊. 一种快速提取血液和口腔拭子基因组DNA的方法[P]. 福建: CN107988210A, 2018-05-04.

[8]方春妮, 杨文辉, 詹杜清, 陈荣山, 谢文龙, 肖辛野, 郑巧凤, 李奇渊, 姚迅. 一种用于检测氯吡格雷个体化用药相关的基因多态性位点的核酸质谱检测试剂盒及应用[P]. 福建: CN107904306A, 2018-04-13.

[9]李奇渊, 朱明, 刘煜达, 张晓龙. 一种血浆DNA边提取边转化的方法及应用[P]. 浙江: CN107868813A, 2018-04-03.

[10]杨文辉, 詹杜清, 方春妮, 谢文龙, 陈荣山, 肖辛野, 李奇渊, 姚迅. 一种叶酸代谢基因多态性位点的基因型检测方法及试剂盒[P]. 福建: CN107630073A, 2018-01-26.

[11]刘青青, 谢文龙, 李珊, 王松林, 陈荣山, 肖辛野, 李奇渊, 姚迅. 一种16S rDNA高通量测序文库的构建方法[P]. 福建: CN106282177A, 2017-01-04.

[12]李珊, 谢文龙, 刘青青, 王松林, 陈荣山, 肖辛野, 李奇渊, 姚迅. 一种肺泡灌洗液宏基因组的提取方法[P]. 福建: CN106244580A, 2016-12-21.

[13]王松林, 谢文龙, 刘青青, 李珊, 陈荣山, 肖辛野, 李奇渊, 姚迅. 一种口腔咽拭子细菌宏基因组DNA提取方法[P]. 福建: CN106047868A, 2016-10-26.

[14]李珊, 谢文龙, 刘青青, 王松林, 陈荣山, 肖辛野, 李奇渊, 姚迅. 一种海水微生物宏基因组的提取方法[P]. 福建: CN106047869A, 2016-10-26.

发明授权：

[1]刘青青, 谢文龙, 曾缘欢, 陈荣山, 李宇, 温恒斌, 肖辛野, 姚迅, 李奇渊, 李晓哲. 一种循环肿瘤DNA低频突变的检测方法[P]. 福建省: CN108866174B, 2023-05-19.

[2]李奇渊, 朱明, 刘煜达, 张晓龙. 一种血浆DNA边提取边转化的方法及应用[P]. 上海市: CN107868813B, 2021-07-27.

[3]方春妮, 杨文辉, 詹杜清, 陈荣山, 谢文龙, 肖辛野, 郑巧凤, 李奇渊, 姚迅. 一种用于检测氯吡格雷个体化用药相关的基因多态性位点的核酸质谱检测试剂盒及应用[P]. 福建省: CN107904306B, 2021-03-30.

[4]曾缘欢, 刘青青, 谢文龙, 陈荣山, 李宇, 温恒斌, 陈詹妮, 林程宏, 黄书鑫, 林俭耀, 姚迅, 李奇渊. 一种林奇综合征相关基因变异的检测方法[P]. 福建省: CN108192971B, 2020-10-16.

[5]李珊, 谢文龙, 刘青青, 王松林, 陈荣山, 肖辛野, 李奇渊, 姚迅. 一种肺泡灌洗液宏基因组的提取方法[P]. 福建省: CN106244580B, 2019-05-24.

[6]李珊, 谢文龙, 刘青青, 王松林, 陈荣山, 肖辛野, 李奇渊, 姚迅. 一种海水微生物宏基因组的提取方法[P]. 福建省: CN106047869B, 2019-05-24.

[7]王松林, 谢文龙, 刘青青, 李珊, 陈荣山, 肖辛野, 李奇渊, 姚迅. 一种口腔咽拭子细菌宏基因组DNA提取方法[P]. 福建省: CN106047868B, 2019-05-21.

软件著作：

1. 单细胞数据的无偏降采样系统 [简称:MURP]V1.0 2023SR1327445

2. 从超低深度全基因组测序中分析肿瘤体细胞突变标签的软件 [简称:ulcSig]V1.0 2023SR1565307

代表性英文论文：

[1]Huanhuan Liu, Qinwei Chen, Jintao Guo, Ying Zhou, Zhiyu You, Jun Ren, Yuanyuan Zeng, Jing Yang, Jialiang Huang, Qiyuan Li*, Epigenome-augmented eQTL-hotspots reveal genome-wide transcriptional programs in 36 human tissues, Briefings in Bioinformatics, 2024, 25(3): bbae109.

[2]Qingqing Qin, Ying Zhou, Jintao Guo, Qinwei Chen, Weiwei Tang, Yuchen Li, Jun You, Qiyuan Li*. Conserved methylation signatures associate with the tumor immune microenvironment and immunotherapy response. Genome Medicine 16, 47 (2024).

[3]Jun Ren, Xuejing Lyu, Jintao Guo, Xiaodong Shi, Ying Zhou, Qiyuan Li*.CDSKNNXMBD: a novel clustering framework for large-scale single-cell data based on a stable graph structure[J]. Journal of Translational Medicine, 2024, 22(1): 233.

[4]Qi, Fangyu,You, Zhiyu,Guo, Jiayang,Hong, Yongjun,Wu, Xiaolong,Zhang, Dongdong.Chengfu Cai*,Qiyuan Li*.An automatic Diagnosis model of otitis media with high accuracy rate using transfer learning.Frontiers in Molecular Biosciences,2024,10

[5]Ou, Kunlin,Zhang, Quan,Xi, Feifei,Ni, Huizhen,Lu, Jiebo,Lyu, Xuejing,Wang, Chonggang.Wang, Qin*,李奇渊*.Prenatal EGCG consumption impacts hepatic glycogen synthesis and lipid metabolism in adult mice.International Journal of Biological Macromolecules,2024,260

[6]Chengxin Li,Song, Jing,Chen, Qihong,Ge, Dandan.Yungang Yang*,Qiyuan Li*.Whole-Genome Shotgun Sequencing Unravels the Influence of Environmental Microbial Co-Infections on the Treatment Efficacy for Severe Pediatric Infectious Diseases.Frontiers in Microbiology,2024,15

[7]Jun Ren,Xiaodong Shi,Jintao Guo,Xuejing Lyu,Hongkun Fang,Jing Yang,Yudi Hu,Ying Zhou.Qiyuan Li*.MGPfactXMBD: A Model-Based Factorization Method for scRNA Data Unveils Bifurcating Transcriptional Modules Underlying Cell Fate Determination.[J].elife,2024,

[8]Xuejing Lyu; Shaona Wang; Jiaxin Zhong; Lingzhu Cai; Yanhui Zheng; Ying Zhou; Ying Zhou;Qionghua Chen; Qiyuan Li* ; Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus, Frontiers in Microbiology, 2023, 14.

[9]Yan Wang,Quan Zhang,He, Tingting,Wang, Yechen,Lu, Tianqi,Chen, Xin,Cheng, Shih-Chin,Mao, Kairui,Liu, Wen-Hsien,Hong, Yazhen,Zhou, Ying,Xie, Jun,Wang, Xinming,Yang, Kang,Lin, Shen,Wang, Yiyi,Wang, Zengge.Nengming Xiao*,Qiyuan Li*.The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells.Nature Communications,2023,14(1):

[10]Chao Yang,Yun Liu,Yudi Hu,Changchun Xiao*,Wen-Hsien Liu*,Qiyuan Li* .Myc inhibition tips the immune balance to promote antitumor immunity.CELLULAR & MOLECULAR IMMUNOLOGY,2022,19(9):1030-1041.

[11]Jun Ren, Quan Zhang, Ying Zhou, Yudi Hu, Xuejing Lyu, Hongkun Fang, Jing Yang, Rongshan Yu, Xiaodong Shi, Qiyuan Li*,Changchun Xiao,Wen-Hsien Liu,Qiyuan Li,A downsampling method enables robust clustering and integration of single-cell transcriptome data.Journal of Biomedical Informatics 130 (2022) 104093

[12]Hu, Yudi; Xu, Chaoqun; Ren, Jun; Zeng, Yuanyuan; Cao, Fengyang; Fang, Hongkun; Jintao, Guo; Zhou, Ying*; Li, Qiyuan,*.Exposure to Tobacco Smoking Induces a subset of Activated Tumor-resident Tregs in Non-Small Cell Lung Cancer.Translational Oncology,2022,15(1):1010261

[13]Xingyuan Zhai†, Kai Liu†, Hongkun Fang†, Quan Zhang, Xianjun Gao, Fang Liu, Shangshang Zhou, Xinming Wang, Yujia Niu, Yazhen Hong, Shu-Hai Lin, Wen-Hsien Liu, Changchun Xiao, Qiyuan Li*, Nengming Xiao*,Mitochondrial C1qbp promotes differentiation of effector CD8+ T cells via metabolic-epigenetic reprogramming.SCIENCE ADVANCES,2021,7(49):1-19

[14]Jintao Guo, Ying Zhou, Chaoqun Xu, Qinwei Chen, Zsófia Sztupinszki, Judit Börcsök, Canqiang Xu, Feng Ye, Weiwei Tang, Jiapeng Kang, Lu Yang, Jiaxin Zhong, Taoling Zhong, Tianhui Hu, Rongshan Yu, Zoltan Szallasi, Xianming Deng, Qiyuan Li*; Genetic Determinants of Somatic Selection of Mutational Processes in 3,566 Human Cancers, Cancer Research, 2021, 81(16):4205-4217

[15]Zhong, Tao-Ling; Zhang, Yi-Wei; Yao, Xiang-Yang; Xu, Guang-Hui; Liu, Hui; Xu, Qiu-Shi; Sun, Wei; Li, Zhi-Bin; Yang, Yun-Gang; Wu, Jin-Zhun; Zheng, Chao; Li, Qi-Yuan*; Zhou, Lin-Fu*.Association between atmospheric concentration of particulate matters and inpatient and outpatient visits for chronic respiratory diseases in Xiamen, China.Chinese Medical Journal, 2021, 134(13): 1616-1618.

[16]Zhan, Juan; Sun, Shenghua; Chen, Yixing; Xu, Chaoqun; Chen, Qinwei; Li, Minjie; Pei, Yihua; Li, Qiyuan.MiR-3130-5p is an intermediate modulator of 2q33 and influences the invasiveness of lung adenocarcinoma by targeting NDUFS1.Cancer Medicine, 2021, 10(11): 3700-3714.

[17]Li, Qiyuan; Zeng, Yuanyuan; Wang, Janet; Fang, Hongkun; Guo, Jintao; Yu, Liying; Zhong, Taoling; Xu, Chaoqun; Freedman, Matthew; LaFramboise, Thomas*,Exonic variants undergoing allele-specific selection in cancers.BMC Medical Genomics, 2021, 14(1): 142.

[18]Yang, Lingtao; Chen, Wei*; Li, Li; Xiao, Yueyue; Fan, Shilin; Zhang, Quan; Xia, Tian; Li, Mengjie; Hong, Yazhen; Zhao, Tongjin; Li, Qiyuan; Liu, Wen-Hsien*; Xiao, Nengming*.Ddb1 Is Essential for the Expansion of CD4(+) Helper T Cells by Regulating Cell Cycle Progression and Cell Death.Frontiers in Immunology, 2021, 12: 722273.

[19]You, Jun; Li, Jiayi; Ke, Chunlin*; Xiao, Yanru; Lu, Chuanhui; Huang, Fakun; Mi, Yanjun*; Xia, Rongmu*; Li, Qiyuan*。Oncogenic long intervening noncoding RNA Linc00284 promotes c-Met expression by sponging miR-27a in colorectal cancer.Oncogene, 2021, 40(24): 4151-4166.

[20]Li, Wenzhi; Xu, Chaoqun; Guo, Jintao; Liu, Ke; Hu, Yudi; Wu, Dan; Fang, Hongkun; Zou, Yun; Wei, Ziwei; Wang, Zhong; Zhou, Ying*; Li, Qiyuan*.Cis- and Trans-Acting Expression Quantitative Trait Loci of Long Non-Coding RNA in 2,549 Cancers With Potential Clinical and Therapeutic Implications.Frontiers in Oncology, 2020, 10: 602104.

[21]Wu, Jinzhun; Ge, Dandan; Zhong, Taoling; Chen, Zuojia; Zhou, Ying; Hou, Lingyun; Lin, Xiaoliang; Hong, Jiaxu; Liu, Kuai; Qi, Hui; Wang, Chaoying; Zhou, Yulin; Li, Cheng; Wu, Chuan; Wu, Shuiping; Liu, Zuguo*; Li, Qiyuan*.IRF4 and STAT3 activities are associated with the imbalanced differentiation of T-cells in responses to inhalable particulate matters.Respiratory Research, 2020, 21(1): 123.

[22]Liang, Qing; Hu, Yudi; Zhang, Meina; Lin, Chunjie; Zhang, Wei; Li, Ying; Zhu, Ping; Xue, Pengxin; Chen, Yujie; Li, Qiyuan; Wang, Kejia*.The T Cell Receptor Immune Repertoire Protects the Liver From Reconsitution.Frontiers in Immunology, 2020, 11: 584979.

[23]Liang, Qing; Zhang, Meina; Hu, Yudi; Zhang, Wei; Zhu, Ping; Chen, Yujie; Xue, Pengxin; Li, Qiyuan; Wang, Kejia*.Gut Microbiome Contributes to Liver Fibrosis Impact on T Cell Receptor Immune Repertoire.Frontiers in Microbiology, 2020, 11: 571847.

[24]He, Jia; Ou, Shangkun; Ren, Jun; Sun, Huimin; He, Xin; Zhao, Zhongyang; Wu, Han; Qu, Yangluowa; Liu, Tingting; Jeyalatha, Vimalin; Zhang, Liying; Li, Qiyuan; Reinach, Peter Sol; Quantock, Andrew; Hao, Jie*; Liu, Zuguo*; Li, Wei*.Tissue engineered corneal epithelium derived from clinical-grade human embryonic stem cells.Ocular Surface, 2020, 18(4): 672-680.

[25]Yi, Cuili; Li, Qiyuan; Xiao, Jihong*.Familial chilblain lupus due to a novel mutation in TREX1 associated with Aicardi-Goutie'res syndrome.Pediatric Rheumatology, 2020, 18(1): 32.

[26]Zhu, Yu; Zhong, Taoling; Ge, Dandan; Li, Qiyuan*; Wu, Jinzhun*.Multi-Factor Analysis of Single-Center Asthma Control in Xiamen, China.Frontiers in Pediatrics, 2019, 7: 498.

[27]Wu, Jinzhun; Zhong, Taoling; Zhu, Yu; Ge, Dandan; Lin, Xiaoliang; Li, Qiyuan*.Effects of particulate matter (PM) on childhood asthma exacerbation and control in Xiamen, China.BMC Pediatrics, 2019, 19: 194.

[28]Liu, Ke; Guo, Jintao; Liu, Kuai; Fan, Peiyang; Zeng, Yuanyuan; Xu, Chaoqun; Zhong, Jiaxin; Li, Qiyuan*; Zhou, Ying*.Integrative analysis reveals distinct subtypes with therapeutic implications in KRAS-mutant lung adenocarcinoma.EBioMedicine, 2018, 36: 196-208.

[29]Jintao Guo,Jiankun Huang,Ying Zhou,Yulin Zhou， Liying Yu, Huili Li, Lingyun Hou, Liuwei Zhu，Dandan Ge, Yuanyuan Zeng, Bayasi Guleng* and Qiyuan Li*.Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population.BMC Genomics,2018,19(1):538.

[30]Xu, Shanshan; Li, Qiyuan; Wu, Jinzhun*; Chen, Guobing; Zhu, Bizhen; Gu, Weiyue.Identification of IL2RG and CYBB mutations in two Chinese primary immunodeficiency patients by whole-exome sequencing.Immunological Investigations, 2018, 47(3): 221-228.

[31]Zhang Shihao; Chen Qinghua; Liu Qingxu; Li Yuxi; Sun Xiufeng; Hong Lixin; Ji Suyuan; Liu Chengyan; Geng Jing; Zhang Weiji; Lu Zhonglei; Yin Zhen Yu; Zeng Yuanyuan; Lin Kwang Huei; Wu Qiao; Li Qiyuan; Nakayama Keiko; Nakayama Keiich I; Deng Xianming; Johnson Randy L; Zhu Liang; Gao Daming; Chen Lanfen*; Zhou Dawang*.Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2.Cancer Cell, 2017, 31(5): 669-+.

[32]Zhang Lu; Li Xiaoyu; Li Qiyuan; Ge Shengxiang; Chen Mengyuan; Huan Shuizhen; Chen Binbin; Li Peng; Teng Bogang; Xu Jing; Zhao Shupeng; Qi Fengjie; Zhang Yongxing.Rare RET Variant p.D707E in a Chinese Pedigree with Hereditary Medullary Thyroid Carcinoma.Pathobiology, 2017, 84(3): 152-160.

[33]Hong Jiaxu; Zhong Taoling; Li Huili; Xu Jianming; Ye Xiaofang; Mu Zhe; Lu Yi; Mashaghi Alireza; Zhou Ying; Tan Mengxi; Li Qiyuan; Sun Xinghuai; Liu Zuguo*; Xu Jianjiang.Ambient air pollution, weather changes, and outpatient visits for allergic conjunctivitis: A retrospective registry study.Scientific Reports, 2016, 6(1): 23858.

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[40]Li Q, Stram A, Chen C, Kar S, Gayther S, Pharoah P, Haiman C, Stranger B, Kraft P, Freedman ML. Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types.Hum Mol Genet., 2014, 23(19): 5294-5302.

[41]Wang Huan Huan; Xie Na Na; Li Qi Yuan; Hu Yi Qun; Ren Jian Lin*; Guleng Bayasi.Exome Sequencing Revealed Novel Germline Mutations in Chinese Peutz-Jeghers Syndrome Patients.Digestive Diseases and Sciences, 2014, 59(1): 64-71.

[42]Szasz, A Marcell*; Acs, Balazs*; Agoston, Emese*; Sztupinszki, Zsofia*; Tokes, Anna-Maria*; Szittya, Liliana*; Szekely, Borbala*; Szendroi, Miklos*; Li, Qiyuan*; Harsanyi, Laszlo*; Timar, Jozsef*; Szallasi, Zoltan*; Swanton, Charles*; Gyorffy, Balazs*; Kulka, Janina*.[Simplified, low-cost gene expression profiling for the prediction of outcome in breast cancer based on routine histologic specimens].Orv Hetil, 2013, 154(16): 627-632.

[43]Szasz, Attila Marcell*; Li, Qiyuan*; Eklund, Aron C*; Sztupinszki, Zsofia*; Rowan, Andrew*; Tokes, Anna-Maria*; Szekely, Borbala*; Kiss, Andras*; Szendroi, Miklos*; Gyorffy, Balazs*; Szallasi, Zoltan*; Swanton, Charles*; Kulka, Janina*.The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer.PLos One, 2013, 8(2).

[44]Seo, Ji-Heui*; Li, Qiyuan*; Fatima, Aquila*; Eklund, Aron*; Szallasi, Zoltan*; Polyak, Kornelia*; Richardson, Andrea L*; Freedman, Matthew L*.Deconvoluting complex tissues for expression quantitative trait locus-based analyses.Philos Trans R Soc Lond B Biol Sci, 2013, 368(1620): 20120363-20120363.

[45]Qiyuan Li; Ji-Heui Seo; Barbara Stranger; Aaron McKenna; Itsik Pe’er; Thomas LaFramboise; Myles Brown; Svitlana Tyekucheva; Matthew L. Freedman.Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci.Cell, 2013, 152(3): 633-641.

[46]Birkbak, Nicolai J*; Wang, Zhigang C*; Kim, Ji-Young*; Eklund, Aron C*; Li, Qiyuan*; Tian, Ruiyang*; Bowman-Colin, Christian*; Li, Yang*; Greene-Colozzi, April*; Iglehart, J Dirk*; Tung, Nadine*; Ryan, Paula D*; Garber, Judy E*; Silver, Daniel P*; Szallasi, Zoltan*; Richardson, Andrea L*.Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents.Cancer Discovery, 2012, 2(4): 366-375.

[47]Liu Q; Dai M*; Chen W; Huh C A; Wang G; Li Q; Charette M A.How significant is submarine groundwater discharge and its associated dissolved inorganic carbon in a river-dominated shelf system?Biogeosciences, 2012, 9(5): 1777-1795.

[48]Li, Qiyuan*; Birkbak, Nicolai J*; Gyorffy, Balazs*; Szallasi, Zoltan*; Eklund, Aron C*.Jetset: selecting the optimal microarray probe set to represent a gene..BMC Bioinformatics, 2011, 12: 474-474.

[49]Li, Qiyuan*; Eklund, Aron C*; Birkbak, Nicolai J*; Desmedt, Christine*; Haibe-Kains, Benjamin*; Sotiriou, Christos*; Symmans, W Fraser*; Pusztai, Lajos*; Brunak, Soren*; Richardson, Andrea L*; Szallasi, Zoltan*.Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response..BMC Bioinformatics, 2011, 12: 310-310.

[50]Zhao Y*; Shan Z; Li Q; Zhou Y; Zeng X; Fan Q; Liao C; Zhu Y; Zhao Y; Lu X; Liu J.Effect of CD4(+) Memory T Cells on Rejection Response of Ectopic Heart Transplantation in Mice.Transplantation Proceedings, 2011, 43(5): 1989-1993.

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[53]Li, Qiyuan*; Eklund, Aron C*; Juul, Nicolai*; Haibe-Kains, Benjamin*; Workman, Christopher T*; Richardson, Andrea L*; Szallasi, Zoltan*; Swanton, Charles*. Minimising immunohistochemical false negative ER classification using a complementary 23 gene expression signature of ER status. PLoS One 2010, 5(12):e15031.

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发表中文期刊论文：

[1]游至宇, 阳倩, 傅姿晴, 陈庆超, 李奇渊. 基于Transformer的预训练语言模型在生物医学领域的应用[J]. 厦门大学学报(自然科学版), 2024, 63 (05): 883-893.

[2]曾园媛, 游至宇, 周颖, 李奇渊. 基于生物学知识库的临床预测深度学习算法研究进展[J]. 中国数字医学, 2023, 18 (08): 42-50+66.

[3]许珊珊, 李奇渊, 吴谨准, 陈国兵, 朱碧溱, 谷为岳. 采用全外显子测序分析技术诊断X连锁慢性肉芽肿病一家系[J]. 福建医科大学学报, 2018, 52 (01): 66-68.

[4]王义权,姚冠华,牛建军,黄磊,纪念念,李奇渊,黄建炜,邵寒娟,陈亮,章军,宋思扬,彭宣宪. SARS冠状病毒基因片段变异分析[J]. 厦门大学学报(自然科学版), 2003, (05): 545-547.

[5]李奇渊,章军. 抗人类免疫缺陷病毒蓝藻蛋白-N研究进展[J]. 中国新药与临床杂志, 2003, (06): 371-375.

探索学科交叉共谋学术发展

1月26日上午9点，医学院和信息学院在翔安校区医学院会议室举办了两院第一次学科交叉专题研讨会。医学院参会的有刘祖国院长，王彦晖副院长、胡天惠副院长，以及李奇渊、张杰、颜江华等医学院教授代表。由信息学院李军院长带队的来自计算机科学系、通信工程系和自动化系的10位教师参加了会议，他们是教授王博亮、丁兴号、黄联芬、吉国力、罗雄彪，副教授黄绍辉、黄悦、蔡聪波，助理教授王连生、黄晓阳。

刘祖国院长和李军院长首先简要地介绍了各自学院的参会教师，随后由厦门大学数字医疗技术研发中心常务副主任丁兴号教授就医学成像与图像处理、数字中医与健康工程、数字器官与手术仿真、3D打印技术在医学中的应用四个研究方向详细介绍了中心近年来的研究成果。接着，信息学院2015年新聘“海归”教师罗雄彪教授详细讲解了他近7年来在日本和加拿大从事临床镜像治疗研究的最新成果。他们的报告引起了医学院参会教师的浓厚兴趣，来自两个学院的教师各自就人工智能与机器学习、脑科学计划、分子生物医学、3D打印、视网膜成像等技术做了介绍，随后进行了具体的对接和深入的探讨。

刘祖国院长指出，医学院和信息学院可以通过信息技术在基础医学和临床医学中的交叉应用，实现学科发展双赢。他希望以今天的会议作为开端，实现两院课题负责人之间、课题组之间的直接对接，特别是依托信息学院在3D打印技术应用、远程医疗诊断技术、生物信息学三个方面的专业优势，联合打造科研团队，力争在国家下一轮“脑计划”和“智慧医疗”等重大科研专项中获得资助。通过实现团队工作的互认、成果共享，有效促进两院间的学科交叉，增强双方团队的科研竞争力。

李军院长强调2015年信息学院的工作重点将是推动学科交叉，促进学科建设国际化，希望借助与医学学科群的交叉，重点在智慧医疗、移动医疗、数字中医诊断以及大数据分析技术在转化医学中的运用等领域，组建由学科带头人领衔的科研团队，与学校优势学科及团队合作，同时借助行业需求之拉动，打造校级交叉学科科研大平台；通过与美国和加拿大一流高校的合作，推动信息学科的跨越式发展。

双方决定会后将落实共建学科交叉科研平台、互认科研成果、联合申报国家和地方的科研项目、实施研究生联合培养导师组等具体措施，使两院的学科交叉落到实处。

来源：厦门大学 2015-02-02

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