袁正伟——中国医科大学附属盛京医院小儿外科临床医学医药科学创新人物科技创新网

袁正伟，男，1966年11月生，医学博士，博士生导师，国家卫健委小儿先天畸形重点实验室主任，中国医科大学附属盛京医院国家儿童区域医疗中心学术带头人，中华医学会小儿外科分会委员，辽宁省医学会小儿外科分会副主委，辽宁省医学会理事，辽宁省细胞学会干细胞与再生专业委员会副主任委员，辽宁省科技创新领军人才，辽宁省优秀专家，辽宁省高校创新团队负责人。担任中华小儿外科杂志编委，Neuroproteomics副主编，Frontiers in cell and developmental biology副主编，Journal of Integrated OMICS副主编，发育医学杂志副主编。荣获2001年日本武藤医学奖，2002年辽宁省优秀中青年骨干教师，2006年中国医科大学科学研究与技术开发特殊贡献奖励津贴，2007年中国医科大学优秀专家，2007年辽宁省百千万人才工程百人层次，2014年辽宁省高校创新团队带头人，2018年辽宁省优秀专家，2019年辽宁省“兴辽英才计划”科技创新领军人才，2021年被评为二级教授。作为第一负责人先后获得9项国家自然科学基金，2项国家重点专项课题，1项国家重点专项子课题，1项973子课题，获得科研经费总计2000余万元。在国外核心期刊发表论文252篇，其中SCI收录154篇（第一或通讯作者66篇，其中中科院分区1区8篇、2区28篇）。作为第一完成人科研成果获得辽宁省科技进步一等奖1项，中国医院协会医院科技创新三等奖1项；作为第二完成人获得国家科技进步二等奖1项，辽宁省科技进步一等奖1项，教育部科技进步一等奖1项，辽宁省科技进步二等奖1项，三等奖2项。获得发明专利6项，其中专利成果转化1项，转化金额100万元。指导研究生62人，其中博士研究生36人，硕士研究生26人，培养的博士研究生荣获辽宁省优秀学位论文。

教育经历：

1983年-1989年，毕业于中国医科大学医学系，医学学士学位。

1989-1992中国医科大学附属盛京医院医学硕士学位小儿外科

1994-1997中国医科大学附属盛京医院医学博士学位小儿外科

工作经历：

1992-2003中国医科大学附属盛京医院副教授小儿外科。

1999-2002香港大学RA基础研究。

2003-至今中国医科大学附属盛京医院教授,副主任小儿外科。

学术兼职及社会任职：

1. 中华医学会小儿外科分会委员。

2. 中华医学会小儿外科分会中青年委员会副主任委员。

3. 辽宁省医学会理事。

4. 辽宁省细胞学会干细胞与再生专业委员会副主任委员。

5. 辽宁省医学会小儿外科分会委员,中华小儿外科杂志编委。

6. Journal of Integrated OMICS副主编。

7. Neuroproteomics副主编。

8. 发育医学杂志副主编。

研究方向：

1. 小儿先天畸形胚胎发育及其遗传基因筛查。

2. 感染因素所致先天畸形的机理研究。

3. 遗传病分子遗传学研究。

承担科研项目情况：

先后获得国家自然基金6项，参加973项目1项，获得科研经费500余万元。

1、儿童结构出生缺陷防控和救助体系的构建及示范应用，批准号：2021YFC2701003，科技部，袁正伟，658万元，2021.12-2024.11

2、重大出生缺陷中基因突变致病性的系统识别及其非经典致病机制解析，批准号：2021YFC2701104，科技部，袁正伟，150万元，2021.12-2024.11

3、神经管畸形发生的关键基因筛选、验证及交互调控新机制研究，批准号：82171649，国家自然科学基金，袁正伟，55万元，2022.1-2025.12

4、宫内羊膜腔注射移植的干细胞向神经管畸形病变部位定向迁移的分子机制研究及其远期神经功能恢复的效果评价，批准号：81871219，国家自然科学基金，袁正伟，57万元，2019.1-2022.12

5、利用新筛选的血清分子标志物构建神经管畸形产前诊断模型及其机制研究，81671469，国家自然科学基金，袁正伟，57万元，2017.1-2020.1

6、出生缺陷的预测预警及早期诊断的优化方案，批准号：2016YFC1000505，科技部，袁正伟，480万元，2016.7-2021.6

7、血浆铜蓝蛋白作为神经管畸形胚胎早期诊断分子标志物的价值及其机制探讨，批准号：81370717，国家863计划子项目，袁正伟，70万元，2014.1.-2017.12

8、代谢物失衡和信号通路异常致出生缺陷的分子机理，批准号：2013CB945402，973项目子课题，袁正伟，100万元，2013.1-2015.12

9、骨髓间充质干细胞移植联合RNAi沉默CRMP4对先天性脊椎裂胚胎早期治疗，批准号：39770763，国家自然科学基金，袁正伟，62万元，2012.1-2015.12

10、利用具有不同分化特性的骨髓间充质干细胞单细胞克隆构建组织工程支架进行先天性显性脊柱裂治疗的研究，批准号：81070538 国家自然科学基金，袁正伟，40万元，2011.1-2013.12

11、干细胞移植在胚胎组织内迁移、分化规律及其对隐性脊椎裂治疗效果研究，批准号：30872705，国家自然科学基金，袁正伟，35万元，2009.1-2011.12

12、先天性脊椎裂、先天性肛门直肠畸形和先天性马蹄内翻足的共同胚胎发生规律与早期诊断研究，批准号：30571934，国家自然科学基金，袁正伟，26，2006.1-2008.12

13、骨髓间充质干细胞移植联合14-3-3基因转染治疗先天性脊椎裂的新方法研究，教育部博士点基金，12万元，2013.01-2015.12。

14、先天畸形胚胎发生机制与早期诊断、预防新策略，辽宁省教育厅创新团队，100万元，2014.01-2016.12。

15、小儿排尿功能障碍的诊断与治疗小儿外科术后康复与功能重建小儿神经管畸形的基础与临床研究。

科研成果：

1. 获辽宁省科技进步奖多项。编写《小儿排尿功能障碍的诊断与治疗》一书。

2. 从事的课题建立了神经电生理、多导直肠肛管向量测压、X线和同位素动态排便造影等手段系统研究肛门直肠畸形术后排便功能障碍发生的病理机制，提出排便功能障碍的5种病理类型，并在国内外首次创造性地设计有针对性的生物反馈治疗方法，排便功能评分平均增加2分以上，成为有效治疗肛门直肠畸形术后排便功能异常的重要手段。这部分内容后来也成为2007年申报国家科技进步奖二等奖的重要创新点之一。

3. 率领课题团队取得了辉煌的成果：国家科技进步奖二等奖1项，教育部科技进步奖一等奖1项，辽宁省科技进步奖一等奖1项，二等奖1项，三等奖2项。在“十五”期间共获得各种科研基金资助30项，其中包括参加“973”工程项目1项，国家自然科学基金13项，省部级重点课题5项等，总资助经费550余万元。在国内外核心期刊共发表论著130余篇，其中有57篇在国外杂志发表并被SCI收录，参编相关专著5部。研究成果在2001年荣获日本武藤医学奖。

认定成果

1 先天性肛门直肠畸形基础与临床研究王维林;袁正伟;张志波;白玉作;李龙;李正;王练英;王常林;冯国和;王伟;贾慧敏;刘颖;刘莹中国医科大学盛京医院 2005

2 先天性肛门直肠畸形的基础与临床研究王维林;袁正伟;张志波;白玉作;李龙;李正;王练英;王常林;王伟;贾慧敏;刘颖;刘莹中国医科大学盛京医院 2005

3 小儿肛门直肠畸形术后生物反馈治疗及远期生活质量评估的研究王维林;白玉作;袁正伟;王伟;陈辉;李志祥;肖福大;黄英;郝晶中国医科大学盛京医院 2001

论文专著：

发表论文100余篇，其中SCI收录论文50余篇。

编写《小儿排尿功能障碍的诊断与治疗》一书。

代表性英文论文：

[1]Kong, Linghui; Chu, Guoming; Ma, Wei; Liang, Jiajian; Liu, Dan; Liu, Qiushi; Wei, Xiaowei; Jia, Shanshan; Gu, Hui; He, Yiwen; Luo, Wenting; Cao, Songying; Zhou, Xiaomeng; He, Rong*; Yuan, Zhengwei*.Mutations in VWA8 cause autosomal-dominant retinitis pigmentosa via aberrant mitophagy activation.Journal of Medical Genetics, 2023. IF=5.941，1区

[2]Huang, Wanqi; Fu, Jialin; Yuan, Zhengwei*; Gu, Hui*.Impact of prenatal exposure to metallic elements on neural tube defects: Insights from human investigations.Ecotoxicology and Environmental Safety, 2023, 255: 114815. IF=7.129，1区

[3]Wei, Xiaowei; Ma, Wei; Gu, Hui; Liu, Dan; Luo, Wenting; Cao, Songying; Jia, Shanshan; Huang, Tianchu; He, Yiwen; Bai, Yuzuo; Wang, Weilin; Yuan, Zhengwei*.Intra-amniotic mesenchymal stem cell therapy improves the amniotic fluid microenvironment in rat spina bifida aperta fetuses.Cell Proliferation, 2023, 56(2).e13354. IF=8.755，1区

[4]Yin, Jiali; Shi, Dongxin; Sun, Yan; Zhu, Peiyao; Zhao, Yiping; Xu, Xuegang; Chen, Hongduo; Wu, Yan*; Yuan, Zhengwei*; Gao, Xing-Hua*.IRF7 and CTSS are pivotal for cutaneous wound healing and may serve as therapeutic targets.Signal Transduction and Targeted Therapy, 2023, 8(1): 322.

[5]Chen, Lizhu; Xiu, Yun; Wu, Qijun; Wang, Yu; Zhang, Yixin; Xue, Jia; Wang, Qinbo; Yuan, Zhengwei*.Maternal serum Lamin A is a potential biomarker that can predict adverse pregnancy outcomes.EBioMedicine, 2022, 77: 103932.. IF=11.205，1区

[6]Zhao, Duan; Liu, Yusi; Jia, Shanshan; He, Yiwen; Wei, Xiaowei; Liu, Dan; Ma, Wei; Luo, Wenting; Gu, Hui*; Yuan, Zhengwei*.Influence of maternal obesity on the multi-omics profiles of the maternal body, gestational tissue, and offspring.Biomedicine & Pharmacotherapy, 2022, 151: 113103.. IF=7.419，1区

[7]Li SY, Wang CY, Wei XG, Tang XB, Yuan ZW, Bai YZ. CircJag1 promotes apoptosis of ethylene thiourea-exposed anorectal malformations through sponging miR-137-3p by regulating Sox9 and suppressing Wnt/β-catenin pathway during the hindgut development of rat embryos. Cell Biol Toxicol. 2022 Aug 5. doi: 10.1007/s10565-022-09750-0. Epub ahead of print. IF=6.819，1区

[8]Liu P, Li Y, Wang W, Bai Y, Jia H, Yuan Z, Yang Z. Role and mechanisms of the NF-ĸB signaling pathway in various developmental processes. Biomed Pharmacother. 2022 Sep;153:113513. IF=7.419，1区

[9]Jia, Shanshan; Zhang, Qiang; Wang, Yu; Wei, Xiaowei; Gu, Hui; Liu, Dan; Ma, Wei; He, Yiwen; Luo, Wenting; Yuan, Zhengwei*.Identification by RNA-Seq of let-7 clusters as prenatal biomarkers for nonsyndromic cleft lip with palate.Annals of the New York Academy of Sciences, 2022, 1516(1): 234-246.

[10]Wang, Yanfu; Ma, Ling; Jia, Shanshan; Liu, Dan; Gu, Hui; Wei, Xiaowei; Ma, Wei; Luo, Wenting; Bai, Yuzuo; Wang, Weilin; Yuan, Zhengwei*.Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers.Journal of Molecular Medicine-JMM, 2022, 100(9): 1307-1319.

[11]Ma, Wei; Wei, Xiaowei; Gu, Hui; Liu, Dan; Luo, Wenting; Cao, Songying; Jia, Shanshan; He, Yiwen; Chen, Lizhu; Bai, Yuzuo; Yuan, Zhengwei*.Intra-amniotic transplantation of brain-derived neurotrophic factor-modified mesenchymal stem cells treatment for rat fetuses with spina bifida aperta.Stem Cell Research & Therapy, 2022, 13(1): 413.

[12]Wang, Yu; Zhang, Qixin; Yin, Chenghuan; Chen, Lizhu; Yang, Zeyu; Jia, Shanshan; Sun, Xue; Bai, Yuzuo; Han, Fangfang*; Yuan, Zhengwei*.Automated prediction of early spontaneous miscarriage based on the analyzing ultrasonographic gestational sac imaging by the convolutional neural network: a case-control and cohort study.BMC Pregnancy and Childbirth, 2022, 22(1): 621.

[13]Li, Shimeng; Wang, Qinbo; Luo, Wenting; Jia, Shanshan; Liu, Dan; Ma, Wei; Gu, Hui; Wei, Xiaowei; He, Yiwen; Cao, Songying; Yuan, Zhengwei*.Relationship between maternal heavy metal exposure and congenital heart defects: a systematic review and meta-analysis.Environmental Science and Pollution Research, 2022, 29(37): 55348-55366.

[14]Luan, Cai-Xia; Xie, Wei-Dong; Liu, Dan; Li, Wei*; Yuan, Zheng-Wei*.Candidate Circulating Biomarkers of Spontaneous Miscarriage After IVF-ET Identified via Coupling Machine Learning and Serum Lipidomics Profiling.Reproductive Sciences, 2022, 29(3): 750-760.

[15]Ma, Ling; Wei, Xiaowei; Ma, Wei; Liu, Yusi; Wang, Yanfu; He, Yiwen; Jia, Shanshan; Wang, Yu; Luo, Wenting; Liu, Dan; Huang, Tianchu; Yan, Jiayu; Gu, Hui; Bai, Yuzuo; Yuan, Zhengwei*.Neural Stem Cell-Derived Exosomal Netrin1 Contributes to Neuron Differentiation of Mesenchymal Stem Cells in Therapy of Spinal Bifida Aperta.Stem Cells Translational Medicine, 2022.

[16]Huang W, Huang T, Liu Y, Fu J, Wei X, Liu D, Ma W, Gu H, Yuan Z. Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects. Cell Death Dis. Cell Death Dis. 2021 Dec 20;13(1):17. IF=9.696，1区

[17]Jia, Shanshan; Zhang, Qiang; Wang, Yu; Wang, Yanfu; Liu, Dan; He, Yiwen; Wei, Xiaowei; Gu, Hui; Ma, Wei; Luo, Wenting; Yuan, Zhengwei*.PIWI-interacting RNA sequencing profiles in maternal plasma-derived exosomes reveal novel non-invasive prenatal biomarkers for the early diagnosis of nonsyndromic cleft lip and palate.EBioMedicine, 2021, 65: 103253. IF=8.143，1区

[18]Huang, Jieting; Zhao, Qi; Wei, Xiaowei; Ma, Wei; Luo, Wenting; Gu, Hui; Liu, Dan; He, Yiwen; Huang, Tianchu; Liu, Yusi; Wang, Chenfei; Yuan, Zhengwei*.miR-351-3p promotes rat amniotic fluid-derived mesenchymal stromal cell proliferation via targeting the coding sequence of Abca4.Stem Cells, 2021, 39(9): 1192-1206.

[19]Zhao, Lu; Liu, Dan; Ma, Wei; Gu, Hui; Wei, Xiaowei; Luo, Wenting; Yuan, Zhengwei*.Bhlhe40/Sirt1 Axis-Regulated Mitophagy Is Implicated in All-Trans Retinoic Acid-Induced Spina Bifida Aperta.Frontiers in Cell and Developmental Biology, 2021, 9: 644346.

[20]Zhang, Siwen; Chang, Qiyuan; Li, Pingping; Tong, Xiaoyu; Feng, Yi; Hao, Xinyao; Zhang, Xudong; Yuan, Zhengwei; Tan, Jichun*.Concentrated small extracellular vesicles from menstrual blood-derived stromal cells improve intrauterine adhesion, a pre-clinical study in a rat model.Nanoscale, 2021, 13(15): 7334-7347.

[21]Li, Zijian; Feng, Juan*; Yuan, Zhengwei*.Key Modules and Hub Genes Identified by Coexpression Network Analysis for Revealing Novel Biomarkers for Spina Bifida.Frontiers in Genetics, 2020, 11: 583316.

[22]Ma, Wei; Wei, Xiaowei; Gu, Hui; Liu, Dan; Luo, Wenting; An, Dong; Bai, Yuzuo; Yuan, Zhengwei*.Therapeutic potential of adenovirus-encoding brain-derived neurotrophic factor for spina bifida aperta by intra-amniotic delivery in a rat model.Gene Therapy, 2020, 27(12): 567-578.

[23]Huang, Jieting; Ma, Wei; Wei, Xiaowei; Yuan, Zhengwei*.Amniotic fluid mesenchymal stromal cells from early stages of embryonic development have higher self-renewal potential.In Vitro Cellular & Developmental Biology-Animal, 2020, 56(9): 701-714.

[24]Dong, Naixuan; Gu, Hui; Liu, Dan; Wei, Xiaowei; Ma, Wei; Ma, Ling; Liu, Yusi; Wang, Yanfu; Jia, Shanshan; Huang, Jieting; Wang, Chenfei; He, Xuan; Huang, Tianchu; He, Yiwen; Zhang, Qiang; An, Dong; Bai, Yuzuo; Yuan, Zhengwei*.Complement factors and alpha-fetoprotein as biomarkers for noninvasive prenatal diagnosis of neural tube defects.Annals of the New York Academy of Sciences, 2020, 1478(1): 75-91.

[25]Liu, Yu-si; Gu, Hui*; Huang, Tian-chu; Wei, Xiao-wei; Ma, Wei; Liu, Dan; He, Yi-wen; Luo, Wen-ting; Huang, Jie-ting; Zhao, Duan; Jia, Shan-shan; Wang, Fang; Zhang, Ting; Bai, Yu-zuo; Wang, Wei-lin; Yuan, Zheng-wei*.miR-322 treatment rescues cell apoptosis and neural tube defect formation through silencing NADPH oxidase 4.CNS Neuroscience & Therapeutics, 2020, 26(9): 902-912.

[26]Huang, Jieting; Wei, Xiaowei; Ma, Wei; Yuan, Zhengwei*.The miR-532-3p/Chrdl1 axis regulates the proliferation and migration of amniotic fluid-derived mesenchymal stromal cells.Biochemical and Biophysical Research Communications, 2020, 527(1): 187-193.

[27]Wei, Xiaowei; Cao, Songying*; Ma, Wei; Zhang, Chaonan; Gu, Hui; Liu, Dan; Luo, Wenting; Bai, Yuzuo; Wang, Weilin; Yuan, Zhengwei*.Intra-Amniotic Delivery of CRMP4 siRNA Improves Mesenchymal Stem Cell Therapy in a Rat Spina Bifida Model.Molecular Therapy - Nucleic Acids, 2020, 20: 502-517.

[28]An Dong; Wei Xiaowei; Zhang Henan; Liu Dan; Ma Wei; Yuan Zhengwei*.Spatiotemporal expression of leukemia inhibitory factor receptor protein during neural tube development in embryos with neural tube defects.Neural Regen Res 2020 Apr;15(4) 705-711, 15(4): 705-711.

[29]Wang Lili; Fan Yang; Zhang Yi; Zhou Fenghua; Yuan Zhengwei*.SEMA3A rs7804122 polymorphism is associated with Hirschsprung disease in the Northeastern region of China.Birth Defects Research Part A-Clinical and Molecular Teratology.

[30]Jia, Shanshan; Wei, Xiaowei; Ma, Ling; Wang, Yanfu; Gu, Hui; Liu, Dan; Ma, Wei; Yuan, Zhengwei*.Maternal, paternal, and neonatal risk factors for neural tube defects: A systematic review and meta-analysis.International Journal of Developmental Neuroscience, 2019, 78: 227-235.

[31]Zhang, Qiang; Yue, Yuanyi; Shi, Bei; Yuan, Zhengwei*.A Bibliometric Analysis of Cleft Lip and Palate-Related Publication Trends From 2000 to 2017.The Cleft Palate-Craniofacial Journal, 2019, 56(5): 658-669.

[32]Zhang, Henan; Guo, Yi; Gu, Hui; Wei, Xiaowei; Ma, Wei; Liu, Dan; Yu, Kun; Luo, Wenting; Ma, Ling; Liu, Yusi; Xue, Jia; Huang, Jieting; Wang, Yanfu; Jia, Shanshan; Dong, Naixuan; Wang, Hongyan*; Yuan, Zhengwei*.TRIM4 is associated with neural tube defects based on genome-wide DNA methylation analysis.Clinical Epigenetics, 2019, 11: 17.

[33]Zhang, He Nan; Guo, Yi; Ma, Wei; Xue, Jia; Wang, Wei Lin; Yuan, Zheng Wei*.MGMT is down-regulated independently of promoter DNA methylation in rats with all-trans retinoic acid-induced spina bifida aperta.Neural Regeneration Research, 2019, 14(2): 361-368.

[34]Gu, Hui; Chen, Lizhu; Xue, Jia; Huang, Tianchu; Wei, Xiaowei; Liu, Dan; Ma, Wei; Cao, Songying; Yuan, Zhengwei*.Expression profile of maternal circulating microRNAs as non-invasive biomarkers for prenatal diagnosis of congenital heart defects.Biomedicine & Pharmacotherapy, 2019, 109: 823-830.

[35]Sun, Li; Yuan, Zhengwei; Jian, Lingyan; Jiang, Qinghua; Zhang, Siwen; Tan, Jichun*.The Modified Bushen Antai Recipe Upregulates Estrogen and Progesterone Receptors at the Maternal-Fetal Interface in Pregnant Rats with Mifepristone-Induced Pregnancy Loss.Evidence-Based Complementary and Alternative Medicine, 2019, 8312020.

[36]Liu Dan; Xue Jia; Liu Yusi; Gu Hui; Wei Xiaowei; Ma Wei; Luo Wenting; Ma Ling; Jia Shanshan; Dong Naixuan; Huang Jieting; Wang Yanfu; Yuan Zhengwei*. Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects.NeuroToxicology, 2018, 69: 84-92.

[37]Xu Xiao Yan; Wei Xiao Wei; Ma Wei; Gu Hui; Liu Dan; Yuan Zheng Wei*.Genome-Wide Screening of Aberrant Methylation Loci for Nonsyndromic Cleft Lip.Chinese Medical Journal, 2018, 131(17): 2055-+.

[38]Xue Jia; Gu Hui; Liu Dan; Ma Wei; Wei Xiaowei; Zhao Lianshuai; Liu Yusi; Zhang Chaonan; Yuan Zhengwei*.Mitochondrial dysfunction is implicated in retinoic acid-induced spina bifida aperta in rat fetuses.International Journal of Developmental Neuroscience, 2018, 68: 39-44.

[39]Gao Song; Wang Yicun; Wang Meng; Li Zhi; Zhao Zhiying; Wang Raymond X; Wu Rong; Yuan Zhengwei; Cui Ranji; Jiao Kai; Wang Lizhong; Ouyang Ling; Liu Runhua.MicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancer.Oncotarget, 2017, 8(25): 41451-41464.

[40]Gao Song; Zhao Zhiying; Wu Rong; Zeng Yuecan; Zhang Zhenyong; Miao Jianing; Yuan Zhengwei*.Bone marrow mesenchymal stem cell transplantation improves radiation-induced heart injury through DNA damage repair in rat model.Radiation and Environmental Biophysics, 2017, 56(1): 63-77.

[41]Li, Xiaoshuai; Yuan, Zhengwei*; Wei, Xiaowei; Li, Hui; Zhao, Guifeng; Miao, Jiaoning; Wu, Di; Liu, Bo; Cao, Songying; An, Dong; Ma, Wei; Zhang, Henan; Wang, Weilin; Wang, Qiushi; Gu, Hui.Application potential of bone marrow mesenchymal stem cell (BMSCs) based tissue-engineering for spinal cord defect repair in rat fetuses with spina bifida aperta.J Mater Sci Mater Med, 2016, 27(4): 77-77.

[42]Wang, Qiushi; Yang, Qiaoni; Wang, Zhe; Tong, Haixia; Ma, Liangyan; Zhang, Yi; Shan, Fengping; Meng, Yiming; Yuan, Zhengwei*.Comparative analysis of human mesenchymal stem cells from fetal-bone marrow, adipose tissue, and Warton's jelly as sources of cell immunomodulatory therapy.Hum Vaccin Immunother, 2016, 12(1): 85-96.

[43]Zhou, Feng-Hua; Fan, Yang; Wei, Xiao-Wei; Wang, Li-Li; Miao, Jia-Ning; Li, Hui; Shan, Li-Ping; Yuan, Zheng-Wei*.Enhanced expression of collapsin response mediator protein 4 in spinal cords of rat fetuses with spina bifida aperta.International Journal of Clinical and Experimental Medicine, 2016, 9(2): 1576-1584.

[44]Cao, Songying; Wei, Xiaowei; Li, Hui; Miao, Jianing; Zhao, Guifeng; Wu, Di; Liu, Bo; Zhang, Yi; Gu, Hui; Wang, Lili; Fan, Yang; An, Dong; Yuan, Zhengwei*.Comparative Study on the Differentiation of Mesenchymal Stem Cells Between Fetal and Postnatal Rat Spinal Cord Niche.Cell Transplantation, 2016, 25(6): 1115-1130.

[45]Chen, Lizhu; Gu, Hui; Li, Jun; Yang, Ze-Yu; Sun, Xiao; Zhang, Li; Shan, Liping; Wu, Lina; Wei, Xiaowei; Zhao, Yili; Ma, Wei; Zhang, Henan; Cao, Songying; Huang, Tianchu; Miao, Jianing; Yuan, Zhengwei.Comprehensive maternal serum proteomics identifies the cytoskeletal proteins as non-invasive biomarkers in prenatal diagnosis of congenital heart defects.Scientific Reports, 2016, 6: 19248-19248.

[46]Cao, Songying; Wei, Xiaowei; Li, Hui; Miao, Jianing; Zhao, Guifeng; Wu, Di; Liu, Bo; Zhang, Yi; Gu, Hui; Wang, Lili; Fan, Yang; An, Dong; Yuan, Zhengwei.Comparative study on the differentiation of mesenchymal stem cells between fetal and postnatal rat spinal cord niche.Cell Transplantation, 2015.

[47]Ma, Wei; Wei, Xiaowei; Gu, Hui; Li, Hui; Guan, Kaoping; Liu, Dan; Chen, Lizhu; Cao, Songying; An, Dong; Zhang, Henan; Huang, Tianchu; Miao, Jianing; Zhao, Guifeng; Wu, Di; Liu, Bo; Wang, Weilin; Yuan, Zhengwei*.Sensory neuron differentiation potential of in utero mesenchymal stem cell transplantation in rat fetuses with spina bifida aperta.Birth Defects Res A Clin Mol Teratol, 2015, 103(9): 772-779.

[48]Ma, Wei; Wei, Xiaowei; Gu, Hui; Li, Hui; Guan, Kaoping; Liu, Dan; Chen, Lizhu; Cao, Songying; An, Dong; Zhang, Henan; Huang, Tianchu; Miao, Jianing; Zhao, Guifeng; Wu, Di; Liu, Bo; Wang, Weilin; Yuan, Zhengwei.Sensory neuron differentiation potential of in utero mesenchymal stem cell transplantation in rat fetuses with spina bifida aperta.Birth Defects Res A Clin Mol Teratol, 2015, 103(9): 772-779.

[49]An, Dong; Wei, Xiaowei; Li, Hui; Gu, Hui; Huang, Tianchu; Zhao, Guifeng; Liu, Bo; Wang, Weilin; Chen, Lizhu; Ma, Wei; Zhang, Henan; Cao, Songying; Yuan, Zhengwei.Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics.Scientific Reports, 2015, 5: 17559-17559.

[50]Tang, Xiao-Bing; Zhang, Jin; Wang, Wei-Lin; Yuan, Zheng-Wei; Bai, Yu-Zuo.Temporal and spatial expression of caudal-type homeobox proteins in the midgut of human embryos.International Journal of Clinical and Experimental Medicine, 2015, 8(11): 19895-19904.

[51]An, Dong; Wei, Xiaowei; Li, Hui; Gu, Hui; Huang, Tianchu; Zhao, Guifeng; Liu, Bo; Wang, Weilin; Chen, Lizhu; Ma, Wei; Zhang, Henan; Cao, Songying; Yuan, Zhengwei*.Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics.Sci Rep, 2015, 5: 17559-17559.

[52]Liu, Zhenjiang*; Yuan, Zhengwei; Zhao, Qun.SELDI-TOF-MS Proteomic Profiling of Serum, Urine, and Amniotic Fluid in Neural Tube Defects.PLos One, 2014, 9(7): e103276.

[53]Liu, Xiaomei*; Qi, Ying; Tian, Baoling; Chen, Dong; Gao, Hong; Xi, Chunyan; Xing, Yanlin; Yuan, Zhengwei.Maternal protein restriction induces alterations in hepatic tumor necrosis factor-alpha/CYP7A1 signaling and disorders regulation of cholesterol metabolism in the adult rat offspring.Journal of Clinical Biochemistry and Nutrition, 2014, 55(1): 40-47.

[54]Ng, R. C-L; Matsumaru, D.; Ho, A. S-H; Garcia-Barcelo, M-M; Yuan, Z-W; Smith, D.; Kodjabachian, L.; Tam, P. K-H; Yamada, G.; Lui, V. C-H*.Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-beta-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations.Cell Death and Differentiation, 2014, 21(6): 978-989.

[55]Zhang, Shu-Cheng; Chen, Fang; Jiang, Kai-Lei; Yuan, Zheng-Wei; Wang, Wei-Lin*.Comparative proteomic profiles of the normal and aganglionic hindgut in human Hirschsprung disease.Pediatric Research, 2014, 75(6): 754-761.

[56]Zhang, Shucheng; Jiang, Kailei; Yuan, Zhengwei; Wang, Weilin*.The single nucleotide polymorphisms in Smad-interacting protein 1 gene contribute to its ectopic expression and susceptibility in Hirschsprung's disease.Experimental and Molecular Pathology, 2014, 96(2): 219-224.

[57]Li, Hui; Miao, Jianing; Zhao, Guifeng; Wu, Di; Liu, Bo; Wei, Xiaowei; Cao, Songying; Gu, Hui; Zhang, Yi; Wang, Lili; Fan, Yang; Yuan, Zhengwei*.Different expression patterns of growth factors in rat fetuses with spina bifida aperta after in utero mesenchymal stromal cell transplantation.Cytotherapy, 2014, 16(3): 319-330.

[58]Li H, Miao J, Zhao G, Wu D, Liu B, Cao S, Zhou F, Gu H, Wang L, Fan Y, Yuan Z*.Different expression pattern of growth factors in rat fetuses with spina bifida aperta after in utero mesenchymal stem cell transplantation. Cytotherapy. 2014, 16(3): 319-330.

[59]Zhang, Shu-Cheng; Wang, Wei-Lin*; Su, Peng-Jun; Jiang, Kai-Lei; Yuan, Zheng-Wei。Decreased enteric fatty acid amide hydrolase activity is associated with colonic inertia in slow transit constipation.Journal of Gastroenterology and Hepatology, 2014, 29(2): 276-283.

[60]Wang, Li-Li; Gu, Hui; Fan, Yang; Zhang, Yi; Wu, Di; Miao, Jia-Ning; Huang, Tian-Chu; Li, Hui; Yuan, Zheng-Wei*.Up-regulated FHL1 Expression Maybe Involved in the Prognosis of Hirschsprung's Disease.International Journal of Medical Sciences, 2014, 11(3): 262-267.

[61]Wei X, Li H, Miao J, Liu B, Zhan Y, Wu D, Zhang Y, Wang L, Fan Y, Gu H, Wang W, Yuan Z. miR-9*- and miR-124a-Mediated Switching of Chromatin Remodelling Complexes is Altered in Rat Spina Bifida Aperta.Neurochemical Research, 2013, 38(8): 1605-1615.

[62]Wu, Li-na; Wei, Xiao-wei; Fan, Yang; Miao, Jia-ning; Wang, Li-li; Zhang, Yi; Wu, Di; Yuan, Zheng-wei*.Altered Expression of 14-3-3 zeta Protein in Spinal Cords of Rat Fetuses with Spina Bifida Aperta.PLos One, 2013, 8(8): e70457.

[63]Wu L, Wei X, Fan Y, Miao J, Wang L, Zhang Y, Wu D, Yuan Z. Altered Expression of 14-3-3 ζ Protein in Spinal Cords of Rat Fetuses with Spina Bifida Aperta. Plos One. 2013, 8(8).

[64]Wei, Xiaowei; Li, Hui*; Miao, Jianing; Liu, Bo; Zhan, Yue; Wu, Di; Zhang, Yi; Wang, Lili; Fan, Yang; Gu, Hui; Wang, Weilin; Yuan, Zhengwei.miR-9*- and miR-124a-Mediated Switching of Chromatin Remodelling Complexes is Altered in Rat Spina Bifida Aperta.Neurochemical Research, 2013, 38(8): 1605-1615.

[65]Fan, Yang; Wang, Lili; Zhang, Yi; Huang, Tianchu; Li, Hui; Gu, Hui; Wang, Weilin; Yuan, Zhengwei*.Comparative proteomics of Hirschsprung's disease.Journal of Proteomics, 2013, 84: 176-184.

[66]Liu, Xiaomei*; Qi, Ying; Gao, Hong; Jiao, Yisheng; Gu, Hui; Miao, Jianing; Yuan, Zhengwei。Maternal protein restriction induces alterations in insulin signaling and ATP sensitive potassium channel protein in hypothalami of intrauterine growth restriction fetal rats.Journal of Clinical Biochemistry and Nutrition, 2013, 52(1): 43-48.

[67]Zhang, Tao; Tang, Xiao Bing; Wang, Li Li; Bai, Yu Zuo*; Qiu, Guang Rong; Yuan, Zheng Wei; Wang, Wei Lin.Mutations and Down-Regulation of CDX1 in Children with Anorectal Malformations.International Journal of Medical Sciences, 2013, 10(2): 191-197.

[68]Yin, Shui Jing; Tang, Xiao Bing; Li, Fei Fei; Zhang, Tao; Yuan, Zheng Wei; Wang, Wei Lin; Bai, Yu Zuo*.Spatiotemporal Expression of Fibroblast Growth Factor 10 in Human Hindgut and Anorectal Development.Cells Tissues Organs, 2013, 198(1): 28-34.

[69]Ma, Yinghuan; Bao, Yongxin; Li, Chenghao; Jiao, Fubin; Xin, Hongjie; Yuan, Zhengwei*.Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling.Neural Regeneration Research, 2012, 7(32): 2485-2491.

[70]Zhang, Shu-Cheng*; Wang, Wei-Lin; Cai, Wei-Song; Jiang, Kai-Lei; Yuan, Zheng-Wei.Engineered measles virus Edmonston strain used as a novel oncolytic viral system against human hepatoblastoma.BMC Cancer, 2012, 12: 427.

[71]Liu, Xiaomei; Wang, Aiyuan; Gao, Hong; Yuan, Zhengwei; Jiao, Yisheng*.Expression and role of the inhibitor of apoptosis protein livin in chemotherapy sensitivity of ovarian carcinoma.International Journal of Oncology, 2012, 41(3): 1021-1028.

[72]Gu, Hui; Li, Hui; Zhang, Li; Luan, Hong; Huang, Tianchu; Wang, Lili; Fan, Yang; Zhang, Yi; Liu, Xiaomei; Wang, Weilin; Yuan, Zhengwei*.Diagnostic role of microRNA expression profile in the serum of pregnant women with fetuses with neural tube defects.Journal of Neurochemistry, 2012, 122(3): 641-649.

[73]Wei, Xiaowei; Li, Hui; Miao, Jianing; Zhou, Fenghua; Liu, Bo; Wu, Di; Li, Shujing; Wang, Lili; Fan, Yang; Wang, Weilin; Yuan, Zhengwei*.Disturbed apoptosis and cell proliferation in developing neuroepithelium of lumbo-sacral neural tubes in retinoic acid-induced spina bifida aperta in rat.International Journal of Developmental Neuroscience, 2012, 30(5): 375-381.

[74]Li, Hui; Gao, Fei; Ma, Lili; Jiang, Junhong; Miao, Jianing; Jiang, Mingyu; Fan, Yang; Wang, Lili; Wu, Di; Liu, Bo; Wang, Weilin; Lui, Vincent Chi Hang; Yuan, Zhengwei*.Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta.Journal of Cellular and Molecular Medicine, 2012, 16(7): 1606-1617.

[75]Shan Liping; Fan Yang; Li Hui; Yuan Zhengwei*.Proteomic analysis of amniotic fluid of pregnant rats with spina bifida aperta.Journal of Proteomics, 2012, 75(4): 1181-1189.

[76]Fan, Yang; Wang, Lili; Zhou, Fenghua; Zhang, Yi; Li, Hui; Shan, Liping; Yuan, Zhengwei*.Comparative proteomics of spinal cords of rat fetuses with spina bifida aperta.Journal of Proteomics, 2011, 75(2): 668-676.

[77]So, Man-Ting*; Leon, Thomas Yuk-Yu; Cheng, Guo; Tang, Clara Sze-Man; Miao, Xiao-Ping; Cornes, Belinda K.; Diem Ngoc Ngo; Cui, Long; Ngan, Elly Sau-Wai; Lui, Vincent Chai-Hang; Wu, Xuan-Zhao; Wang, Bin; Wang, Hualong; Yuan, Zheng-Wei; Huang, Liu-Ming; Li, Long; Xia, Huimin; Zhu, Deli; Liu, Juncheng; Thanh Liem Nguyen; Chan, Ivy Hau-Yee; Chung, Patrick Ho-Yu; Liu, Xue-Lai; Zhang, Ruizhong; Wong, Kenneth Kak-Yuen; Sham, Pak-Chung; Cherny, Stacey S.; Tam, Paul Kwong-Hang.RET Mutational Spectrum in Hirschsprung Disease: Evaluation of 601 Chinese Patients.PLos One, 2011, 6(12): e28986.

[78]Ju, Jun-Jie; Gao, Hong; Li, Hui; Lu, Yao; Wang, Li-Li; Yuan, Zheng-Wei*.No association between the SNPs (rs56134796; rs3824934; rs41302375) in the TRPC6 gene promoter and infantile hypertrophic pyloric stenosis in Chinese people.Pediatric Surgery International, 2011, 27(12): 1267-1270.

[79]Deb, Dilip K.; Wang, Youli; Zhang, Zhongyi; Nie, Hongguang; Huang, Xueshi; Yuan, Zhengwei; Chen, Yunzi; Zhao, Qun*; Li, Yan Chun.Molecular Mechanism Underlying 1,25-Dihydroxyvitamin D Regulation of Nephrin Gene Expression.Journal of Biological Chemistry, 2011, 286(37): 32011-32017.

[80]Wang, Li-Li; Fan, Yang; Zhou, Feng-hua; Li, Hui; Zhang, Yi; Miao, Jia-Ning; Gu, Hui; Huang, Tian-Chu; Yuan, Zheng-Wei*.Semaphorin 3A Expression in the Colon of Hirschsprung Disease.Birth Defects Research Part A-Clinical and Molecular Teratology, 2011, 91(9): 842-847.

[81]Chen, Qing Jiang; Jia, Hui Min; Niu, Zhi Xin; Zhang, Tao; Bai, Yu Zuo; Yuan, Zheng Wei; Wang, Wei Lin*.The Development of Satellite Cells and Their Niche in Striated Muscle Complex of Anorectal Malformations Rat Embryos.Journal of Surgical Research, 2011, 168(1).

[82]Yue, Xiaohong; Fu, Jianhua; Xue, Xindong; Gao, Hong; Liu, Dongyan; Zong, Zhihong; Wang, Wei; Li, Hui; Yuan, Zhengwei.Detection of p16 promoter methylation in premature rats with chronic lung disease induced by hyperoxia.Pediatrics International, 2010, 52(4): 520-526.

[83]Miao, Xiaoping; Leon, Thomas Yuk-Yu; Ngan, Elly Sau-Wai; So, Man-Ting; Yuan, Zheng-Wei; Lui, Vincent Chi-Hang; Chen, Yan; Wong, Kenneth Kak-Yuen; Tam, Paul Kwong-Hang; Garcia-Barcelo, Merce.Reduced RET expression in gut tissue of individuals carrying risk alleles of Hirschsprung's disease.Human Molecular Genetics, 2010, 19(8): 1461-1467.

[84]Wang, Li-Li; Qiu, Guang-Rong; Fu, Wei-Neng; Yuan, Zheng-Wei; Sun, Kai-Lai.Transcriptional regulation of Fhl1 by estradiol in rat myoblastocytes.Steroids, 2010, 75(4-5): 368-372.

[85]Li, Yong; Hou, Xiang-Yu; Yuan, Zheng-Wei; Wang, Wei-Lin*.Quantitative analysis of motor neurons of the levator ani muscle in fetal rats with spina bifida occulta.Surgical Neurology, 2009, 72(6): 652-656.

[86]Chen, Qing Jiang; Jia, Hui Min; Zhang, Shi Wei; Zhang, Shu Cheng; Bai, Yu Zuo; Yuan, Zheng Wei; Wang, Wei Lin.Apoptosis during the development of pelvic floor muscle in anorectal malformation rats.Journal of Pediatric Surgery, 2009, 44(10): 1884-1891.

[87]Guan, Kaoping; Li, Hui; Fan, Yang; Wang, Weilin; Yuan, Zhengwei*.Defective Development of Sensory Neurons Innervating the Levator Ani Muscle in Fetal Rats with Anorectal Malformation.Birth Defects Research Part A: Clinical and Molecular Teratology , 2009, 85(7): 583-587.

[88]Wang, Da-Jia; Bai, Yu-Zuo; Zhang, Shi-Wei; Gao, Hong; Zhang, Shu-Cheng; Zhang, Dan; Zhang, Tao; Yuan, Zheng-Wei; Wang, Wei-Lin.Expression of EphB2 in the development of anorectal malformations in fetal rats.Journal of Pediatric Surgery, 2009, 44(3): 592-599.

[89]Yuan, Zhengwei*; Cheng, Wei; Hou, Ana; Wang, Wei; Zhang, Shucheng; Liu, Dan; Ga, Fei; Li, Hui; Wang, Weilin.Constipation Is Associated With Spina Bifida Occulta in Children.Clinical Gastroenterology and Hepatology, 2008, 6(12): 1348-1353.

[90]Xie, Yi; Chan, Hiuman; Fan, Jianqing; Chen, Yongxiong; Young, Joseph; Li, Wen; Miao, Xiaoping; Yuan, Zhengwei; Wang, Huanmin; Tam, Paul K. H.; Ren, Yi.Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma.Carcinogenesis, 2007, 28(10): 2122-2130.

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发表中文期刊论文：

[1]李可心, 郑阳, 袁正伟, 王晓明. T2* mapping MR成像评价脊髓缺血再灌注后铁死亡的机制研究[J]. 中国临床医学影像杂志, 2024, 35 (01): 7-10.

[2]张燕秋, 付佳琳, 袁正伟, 顾卉. 细胞衰老在神经系统疾病发生发展中的作用[J]. 中国医科大学学报, 2023, 52 (09): 847-851.

[3]张燕秋, 付佳琳, 黄琬淇, 袁正伟, 顾卉. miR-92a-3p在小鼠胚胎神经管闭合中的作用及机制[J]. 发育医学电子杂志, 2023, 11 (04): 241-248.

[4]管藤, 袁正伟, 魏晓伟. 组织工程技术在开放性脊柱裂产前治疗中的应用[J]. 发育医学电子杂志, 2023, 11 (04): 293-300.

[5]陈廖粤, 马巍, 袁正伟. 血清标志物、彩色多普勒超声及两者联合筛查神经管缺陷的研究进展[J]. 发育医学电子杂志, 2022, 10 (06): 470-476.

[6]刘晴, 袁正伟. 生物标志物在神经管畸形产前诊断方面的进展及应用[J]. 发育医学电子杂志, 2021, 9 (06): 475-480.

[7]黄天楚, 黄琬淇, 顾卉, 袁正伟. COLIA1调控小鼠神经细胞迁移在神经管畸形中的作用[J]. 中国医科大学学报, 2021, 50 (11): 966-969.

[8]黄琬淇, 顾卉, 袁正伟. 神经细胞的生物学功能与神经管的形成与闭合[J]. 发育医学电子杂志, 2021, 9 (05): 371-380.

[9]付佳琳, 顾卉, 袁正伟. 神经干细胞增殖在小儿先天神经管畸形发生发展中的作用[J]. 中国实用儿科杂志, 2021, 36 (07): 551-554.

[10]黄琬淇, 刘玉思, 顾卉, 袁正伟. miR-322-5p通过NOX4调控细胞凋亡抑制大鼠神经管畸形发生[J]. 中国医科大学学报, 2021, 50 (07): 582-587.

[11]伍丽婷, 薛佳, 李诗萌, 袁正伟*. 孕妇不同孕周血清碱性磷酸酶变化规律的队列研究[J]. 发育医学电子杂志, 2021, 9 (01): 43-48.

[12]黄天楚, 顾卉*, 袁正伟. 胎儿先天性心脏病无创性产前筛查分子标志物的研究进展[J]. 发育医学电子杂志, 2020, 8 (03): 267-271.

[13]袁正伟*. 神经管畸形发病机制研究进展与新策略[J]. 发育医学电子杂志, 2020, 8 (03): 205-207+183.

[14]杨中华, 王大斌, 刘丹, 贾慧敏, 白玉作, 王维林, 袁正伟*. 先天性肛门直肠畸形术后合并便秘患儿排便功能评定及病因探讨[J]. 临床小儿外科杂志, 2020, 19 (01): 18-25.

[15]董乃萱, 顾卉, 刘丹, 魏晓伟, 马巍, 马玲, 袁正伟*. 孕妇血清淀粉样P物质作为神经管缺陷产前标志物的研究[J]. 中国医科大学学报, 2019, 48 (10): 883-886.

[16]安东*, 袁正伟. 差异蛋白质组学在神经系统疾病生物标志物筛选中的研究进展[J]. 山东医药, 2019, 59 (22): 89-92.

[17]安东*, 袁正伟. 利用同位素标记相对和绝对定量技术筛查神经管畸形胚胎孕鼠血清差异蛋白质谱[J]. 中国医科大学学报, 2019, 48 (04): 315-319+323.

[18]顾卉, 陈骊珠, 薛佳, 黄天楚, 袁正伟*. 先天性心脏病胎儿母体血清中的microRNA表达谱及其诊断意义[J]. 发育医学电子杂志, 2019, 7 (01): 32-37.

张超楠; 马巍; 曹嵩颖; 魏晓伟; 顾卉; 罗文婷; 薛佳; 赵连帅; 黄天楚; 袁正伟*.羊膜腔注射Ad-eGFP对显性脊柱裂胎鼠脊髓缺损区域转染效果的研究.中华小儿外科杂志, 2019, 40(2): 172-176.

薛佳; 刘丹; 顾卉; 魏晓伟; 马巍; 赵连帅; 张超楠; 黄天楚; 袁正伟*.血清铜和血清铜蓝蛋白活力测定对神经管畸形孕鼠诊断价值的研究.中华小儿外科杂志, 2019, 40(1): 53-57.

[19]张强, 袁正伟. 蛋白质组学技术在妊娠期母胎疾病诊断中的应用研究进展[J]. 中国实用妇科与产科杂志, 2018, 34 (06): 700-704.

[20]袁正伟. 先天畸形的胚胎早期诊断与治疗新进展[J]. 发育医学电子杂志, 2018, 6 (02): 69-73.

[21]陈骊珠, 张墨, 马巍, 袁正伟. 蛋白质组学技术在产前诊断生物标志物筛查中的研究进展[J]. 中华全科医学, 2018, 16 (03): 461-464.

[22]陈骊珠, 张墨, 马巍, 袁正伟. 质谱多反应监测技术筛查先天性心脏畸形蛋白标志物的价值[J]. 中华实用诊断与治疗杂志, 2018, 32 (01): 14-17.

[23]陈骊珠, 马巍, 张墨, 袁正伟. 应用iTRAQ技术筛选先天性心脏畸形胎儿母亲血清差异表达蛋白[J]. 中国医科大学学报, 2017, 46 (06): 510-514+518.

[24]马丽丽, 徐延波, 袁正伟. 经脐单孔腹腔镜治疗小儿复杂性阑尾炎的疗效分析[J]. 中国内镜杂志, 2017, 23 (05): 13-18.

[25]王秋实, 刘学勇, 王哲, 杨巧妮, 佟海侠, 马良艳, 张一, 苗佳宁, 袁正伟. 干扰素-γ对脂肪间充质干细胞免疫调节相关基因表达的影响[J]. 解剖科学进展, 2016, 22 (04): 375-378+381.

[26]赵桂锋, 刘波, 苗佳宁, 吴迪, 李慧, 黄天楚, 袁正伟. 先天性显性脊椎裂胎鼠宫内干细胞移植新方法的建立[J]. 山东医药, 2016, 56 (16): 8-10+110.

[27]袁正伟. 先天性肛门直肠畸形病因学研究新进展[J]. 发育医学电子杂志, 2016, 4 (01): 8-12.

[28]魏晓伟, 袁正伟. 反式维甲酸诱导显性脊柱裂胎鼠骶尾部神经前体细胞凋亡和增殖的变化规律研究[J]. 发育医学电子杂志, 2015, 3 (01): 42-46.

[29]刘振江, 袁正伟, 赵群. SELDI技术对开放性脊柱裂胎鼠羊水蛋白质组学的初步分析[J]. 中国医科大学学报, 2014, 43 (01): 26-30+33.

[30]刘晓梅, 焦伊胜, 顾卉, 苗佳宁, 袁正伟. 宫内生长受限子鼠肝脏脂肪代谢关键酶表达的研究[J]. 中国现代医学杂志, 2013, 23 (20): 7-11.

[31]范洋, 苗佳宁, 袁正伟. 双向电泳—飞行时间串联质谱对先天性脊柱裂大鼠脊髓差异表达蛋白的鉴定[J]. 中国医科大学学报, 2012, 41 (06): 561-563.

[32]马英桓, 袁正伟. 维甲酸诱导脊柱裂胎鼠脊髓组织中Caspase-3表达情况[J]. 中国临床解剖学杂志, 2012, 30 (03): 311-314.

[33]刘晓梅, 顾卉, 邢艳琳, 袁正伟. 宫内生长受限胎儿和早期新生儿循环中炎症标志物变化研究[J]. 中国实用儿科杂志, 2011, 26 (12): 937-939.

[34]顾卉, 佟宇鑫, 刘彤, 李慧, 李丹妮, 袁正伟. GST-LMO1融合蛋白表达载体的构建及其在原核细胞中的表达[J]. 中国医科大学学报, 2011, 40 (11): 961-963+978.

[35]顾卉, 佟宇鑫, 刘彤, 李妍, 李丹妮, 袁正伟. hLMO3基因真核表达载体的构建及蛋白的表达和定位[J]. 解剖科学进展, 2011, 17 (04): 347-350.

[36]刘振江, 袁正伟, 赵群. 表面增强激光解析/离子化飞行时间质谱技术在神经管缺陷胎儿母亲血清、尿液和羊水蛋白质标志物筛查中的研究[J]. 中国现代医学杂志, 2010, 20 (05): 738-746.

[37]刘振江, 袁正伟, 赵群, 宋丹丹. 表面增强激光解析/离子化飞行时间质谱技术在神经管缺陷胎儿母亲血清标志物筛查中的应用[J]. 中国妇幼保健, 2010, 25 (05): 650-654.

[38]侯阿娜, 袁正伟, 王维林. 隐性脊柱裂脊髓内NOS1、脂肪及尼氏体含量的组织学分析[J]. 山东医药, 2010, 50 (04): 6-8.

[39]王莉莉, 娄毅, 方长清, 袁正伟. 东北地区汉族人群XPD单核苷酸多态性与结肠癌易感相关性的研究[J]. 中华肿瘤防治杂志, 2009, 16 (17): 1284-1286.

[40]高飞, 李文豪, 蒋俊红, 袁正伟. 小儿异位胃黏膜症57例分析[J]. 中国误诊学杂志, 2009, 9 (13): 3198-3199.

[41]刘振江, 袁正伟, 赵群. 表面增强激光解析离子化飞行时间质谱技术研究神经管缺陷胎儿母亲尿液中蛋白质谱改变规律[J]. 中国医科大学学报, 2009, 38 (03): 220-224.

[42]李慧, 袁正伟. 脑脊液中微量的可溶型晚期糖基化终末产物受体检测方法建立与初步应用[J]. 中国医科大学学报, 2009, 38 (03): 175-177.

[43]李慧, 袁正伟, 陈岩, 谭广亨. CD28/B7和CD134/CD134L共刺激通路阻断与免疫抑制剂联合治疗对移植心脏存活时间影响[J]. 解剖科学进展, 2009, 15 (01): 60-64.

[44]贾慧敏, 陈青江, 张涛, 白玉作, 袁正伟, 王维林. Cajal间质细胞及突触素在肛门直肠畸形动物模型末端直肠壁的表达及意义[J]. 中国医科大学学报, 2009, 38 (01): 11-14.

[45]袁正伟, 白玉作, 王伟. 第6届全国小儿肛肠、肝胆、新生儿外科学术研讨会纪要[J]. 临床小儿外科杂志, 2008, 7 (06): 79.

[46]胡淑敏, 袁正伟, 马怡然, 方文刚, 朱丽, 陈誉华. nNOS和iNOS在神经管畸形胎鼠大脑皮质中的表达及意义[J]. 解剖科学进展, 2007, (02): 107-110.

[47]杨屹, 李勇, 王常林, 袁正伟. 隐性脊柱裂动物模型脊髓神经递质表达的研究[J]. 中华小儿外科杂志, 2007, 28 (04): 204-207.

[48]管考平, 袁正伟, 王维林, 高飞, 苏鹏俊. 先天性肛门直肠畸形胎鼠支配肛提肌感觉神经元定量研究[J]. 中华医学杂志, 2007, 87 (02): 131-133.

[49]张海兰, 高红, 袁正伟, 王维林. 肛门直肠畸形直肠末端c-kit和干细胞因子受体表达的研究[J]. 中华小儿外科杂志, 2006, (12): 631-634.

[50]李剑明, 袁正伟, 徐微娜, 于树鹏, 张彩霞, 裴著果. 核素显像在无肛畸形术后患儿排便功能中的初步研究[J]. 中国医学影像技术, 2006, (09): 1409-1411.

[51]刘丹, 牛之彬, 袁正伟. 128例小儿术后中心静脉压导管的应用与护理[J]. 小儿急救医学, 2005, (06): 502-503.

[52]李勇, 王维林, 袁正伟, 白玉作, 杨屹, 蔡炜嵩. 隐性脊椎裂胎鼠支配肛提肌脊髓运动神经元定量研究[J]. 中华小儿外科杂志, 2005, (12): 658-661.

[53]刘丹,牛之彬,袁正伟. 对肛门成形术后便失禁患者实施生物反馈训练的护理[J]. 中华护理杂志, 2005, (11): 26-27.

[54]杨屹,李勇,王常林,袁正伟. 显性脊柱裂动物模型膀胱胆碱乙酰转移酶多巴胺β羟化酶和降钙素基因相关肽表达的研究[J]. 中国当代儿科杂志, 2005, (04): 354-356.

[55]刘丹,牛之彬,袁正伟. 儿童股骨头骨骺滑脱治疗中的护理[J]. 解放军护理杂志, 2005, (07): 58-59.

[56]蔡炜嵩,赵红宇,袁正伟. 胶质细胞源性神经营养因子对运动神经元发育及运动神经元性疾病的作用[J]. 中国修复重建外科杂志, 2005, (06): 490-493.

[57]王伟,史立伟,袁正伟,王维林. 应用生物反馈训练无肛术后患儿的排便功能(英文)[J]. 中国临床康复, 2005, (23): 214-215.

[58]高飞,袁正伟. 骨髓间充质干细胞的体外培养、诱导分化及在神经系统疾病中的应用[J]. 国外医学(儿科学分册), 2005, (03): 191-193.

[59]王伟,袁正伟,王维林. 三维向量测压在无肛术后患儿排便功能随访与康复治疗中的应用[J]. 中国医科大学学报, 2005, (01): 74-76.

[60]侯翔宇,王维林,袁正伟,张树成,白玉作. 脊髓拴系综合征术后结肠传输时间测定及意义[J]. 中华小儿外科杂志, 2005, (02): 12-14.

[61]张树成,王维林,白玉作,袁正伟. 结肠传输时间测定和直肠肛管测压在儿童便秘中的意义[J]. 中国当代儿科杂志, 2005, (01): 39-42.

[62]蔡炜嵩,袁正伟,郭俊斌,李勇,王维林. 维甲酸致大鼠胚胎神经管畸形的组织形态学观察[J]. 中华小儿外科杂志, 2004, (05): 50-53.

[63]李勇,王维林,袁正伟,白玉作,蔡炜嵩. 脊柱裂动物模型制作与胚胎发生机制探讨[J]. 中华小儿外科杂志, 2004, (05): 54-59.

[64]王伟,袁正伟. 生物反馈训练治疗无肛患儿术后大便失禁[J]. 中华物理医学与康复杂志, 2004, (06): 25-26.

[65]贾慧敏,王维林,袁正伟,白玉作. 先天性肛门直肠畸形胎鼠腰骶髓副交感神经元发育异常的研究[J]. 中华小儿外科杂志, 2004, (03): 87-89.

[66]苏琪,吴硕东,袁正伟,王伟,殷红专,韩霞,刘恩卿. 直肠癌术后肛门外括约肌神经电生理研究[J]. 中国临床康复, 2004, (17): 3308-3309.

[67]袁正伟,王维林,李剑明. 核素排便造影在小儿便秘诊断中的应用价值[J]. 中华儿科杂志, 2004, (05): 42-45+85.

[68]李勇,王维林,袁正伟,杨屹,贾慧敏,蔡炜嵩. 一种简捷可靠的胎鼠骨和软骨双重染色技术[J]. 中国医科大学学报, 2004, (02): 96-97.

[69]袁正伟,王维林,白玉作,王伟. 针对性生物反馈训练的长期疗效随访[J]. 中华医学杂志, 2004, (06): 42-45.

[70]李勇,王维林,袁正伟,白玉作,杨屹,蔡炜嵩. 丙戊酸诱导胎鼠发生隐性脊椎裂畸形的模型建立[J]. 中国当代儿科杂志, 2004, (01): 38-41+1.

[71]曲日斌,张树成,王维林,白玉作,袁正伟. 小儿便秘结肠动力学机制的初步探讨[J]. 中华普通外科杂志, 2003, (08): 21-23.

[72]袁正伟,王维林,谭广亨. 先天性肛门直肠畸形支配盆底肌的脊髓神经元定量研究[J]. 中华医学杂志, 2003, (14): 70-73.

[73]张树成,王维林,白玉作,袁正伟. 先天性巨结肠术后结肠传输时间测定的意义[J]. 中华小儿外科杂志, 2003, (02): 23-25.

[74]白玉作,王维林,王伟,袁正伟. 大鼠肛门直肠畸形的胚胎发育研究[J]. 中华小儿外科杂志, 2003, (02): 58-61+98.

[75]张树成,王维林,白玉作,袁正伟,王伟. 便秘患儿的胃肠传输时间测定及其意义[J]. 中华儿科杂志, 2003, (03): 20-23+84.

[76]袁正伟,王维林,李剑明,白玉作,李正,吉士俊. 先天性无肛畸形排便功能的研究[J]. 中华小儿外科杂志, 2002, (03): 35-37.

[77]白玉作,陈辉,王维林,王伟,袁正伟,李正. 肛门直肠畸形患儿术后30年以上生活质量观察[J]. 中华小儿外科杂志, 2001, (01): 24-26.

[78]袁正伟,王维林,吉士俊,李正,王慧贞. 先天性无肛畸形患儿肛门外括约肌神经电生理研究[J]. 中华医学杂志, 2000, (01): 33-36.

[79]袁正伟,陈苏彦,王维林,王五洲. 易蒙停治疗小儿便失禁的临床应用[J]. 辽宁药物与临床, 1999, (04): 15.

[80]袁正伟,吉士俊,王维林,王慧贞,李正. 先天性肛门闭锁术后大便失禁的生物反馈治疗[J]. 中华小儿外科杂志, 1999, (05): 7-11.

[81]袁正伟,王慧贞,王维林,李正,吉士俊. 排便造影方法对先天性无肛畸形术后肛门直肠功能的评价[J]. 中华小儿外科杂志, 1999, (01): 21-23.

[82]袁正伟，李正，王练英，王伟. 先天性食管裂孔疝患儿手术前后胃食管测压研究[J]. 中国医科大学学报, 1996, (02): 151-154.

[83]袁正伟，李正，王练英，王伟. 先天性上消化道梗阻患儿手术前后胃食管测压研究[J]. 中国医科大学学报, 1996, (01): 70-73.

[84]袁正伟，李正，王练英，王伟. 先天性上消化道梗阻患儿术前、后胃食管测压研究[J]. 中华小儿外科杂志, 1995, (02): 104.

[85]袁正伟，李正，王练英，王伟. 正常新生儿、婴幼儿胃及食管压力测定[J]. 中国医科大学学报, 1994, (04): 374-377.

会议论文：

[1]赵桂锋, 刘波, 苗佳宁, 吴迪, 李慧 & 袁正伟. (2012). 宫内干细胞移植治疗先天性脊椎裂胎鼠的新方法探讨. (eds.) 第十届中国实验动物科学年会论文集 (pp.353-355).

[2]魏晓伟, 李慧 & 袁正伟. (2010). 利用全胚胎体培养方法研究维甲酸对大鼠胚胎的致畸机制. (eds.) 中华医学会第八次全国小儿外科学术会论文集 (pp.140-141).

[3]吴迪, 李慧 & 袁正伟. (2010). 单细胞克隆的挑选与培养. (eds.) 中华医学会第八次全国小儿外科学术会论文集 (pp.424).

[4]顾卉 & 袁正伟. (2010). PAX3 mRNA在胎儿患有先天脊柱裂孕妇外周血中表达显著降低. (eds.) 中华医学会第八次全国小儿外科学术会论文集 (pp.118).

[5]李慧, 吴迪, 苗佳宁 & 袁正伟. (2010). 胚胎期骨髓间充质干细胞移植治疗显性脊柱裂的研究. (eds.) 中华医学会第八次全国小儿外科学术会论文集 (pp.93).

[6]贾慧敏, 陈青江, 张涛, 白玉作, 袁正伟 & 王维林. (2010). Notch-1及其受体Jagged-2在肛门直肠畸形大鼠末端直肠肠神经系统发育过程中的表达变化. (eds.) 中华医学会第八次全国小儿外科学术会论文集 (pp.248).

[7]张涛, 白玉作, 张海兰, 贾慧敏, 袁正伟 & 王维林. (2010). Cdx1基因与先天性肛门直肠畸形的相关研究. (eds.) 中华医学会第八次全国小儿外科学术会论文集 (pp.248-249).

[8]苏琪, 吴硕东, 袁正伟, 王伟, 殷红专, 韩霞 & 刘恩卿. (2004). 直肠癌保肛手术后肛门功能障碍的生物反馈治疗. (eds.) 第九届中日大肠肛门病学术交流会暨2004’中国肛肠外科论坛论文汇编 (pp.108-112).

[9]Cao, S. Y.; Yuan, Z. W.。Therapeutic Potential of RNAi Silencing CRMP-4 Combined with MSCs in Animal Models with Spina Bifida Aperta

[10]Ng, Roy Chun Laam; Lui, Vincent Chi Hang; Garcia-Barcelo, Maria-Mercedes; Yuan, Zheng Wei; Tam, Paul Kwong Hang。Wnt antagonists regulate urethra tubercularization and cloaca septation。16th Annual Conference of the International-Society-of-Development-Biologists, 2009-09-06 to 2009-09-10.

[11]Tam, P. K. H.; Tang, C. S. M.; Ngan, E. S. W.; Lui, V. C. H.; Chen, Y.; So, M. T.; Leon, T. Y. Y.; Miao, X. P.; Shum, C. K. Y.; Liu, F. Q.; Yeung, M. Y.; Yuan, Z. W.; Guo, W. H.; Liu, L.; Sun, X. B.; Huang, L. M.; Tou, J. F.; Song, Y. Q.; Chan, D.; Cheung, K. M. C.; Wong, K. K. Y.; Cherny, S. S.; Sham, P. C.; Garcia-Barcelo, M. M.Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease

我院成功举办全国小儿外科肛肠疾病专题研讨会

金秋十月，秋高气爽。由中华医学会小儿外科分会主办、我院小儿外科承办的中华小儿外科学会小儿肛肠疾病专题研讨会10月15-17日在古城西安锦苑富润大饭店隆重召开，全国多名小儿外科知名专家出席会议。

本次会议是中华医学会小儿外科分会肛肠组换届以来首次会议。应中华医学会小儿外科分会肛肠组副组长、我院副院长、小儿外科博士生导师高亚教授邀请，中华医学会小儿外科分会肛肠组组长、中国医科大学附属盛京医院王维林教授，肛肠组副组长、解放军总医院刘洲禄教授、湖南省儿童医院周小渔教授及肛肠组成员、重庆医科大学附属儿童医院周德凯教授、首都医科大学附属北京儿童医院陈亚军教授、广州市儿童医院朱德力教授、中国医科大学附属盛京医院袁正伟教授等十二名国内知名小儿外科专家齐聚西安，共谋小儿外科肛肠疾病诊治新发展。我院小儿外科主任徐泉教授、张宪生教授、吴宣林副教授以及小儿外科多名医师参加会议。会议旨在研究讨论小儿巨结肠同源病、小儿便失禁、排便障碍性生物反馈训练、小儿功能性便秘的诊断标准及治疗流程方案。会议由高亚教授主持，他首先代表我院对各位专家在百忙之中来到西安参会表示热烈的欢迎，同时高度评价了本次研讨会对小儿肛肠疾病的重大意义。会议期间，组长王维林教授全面阐述了上述疾病的国内外研究进展情况，并提出了指导性意见。各位与会代表积极发言，分别汇报了各自所做的工作。高亚教授就先天性巨结肠有关内容做了专题报告，会议讨论气氛热烈，达到了会议的预期目的。

会议结束时，各位专家对我院成功举办此次研讨会表示热烈祝贺，并对会议期间会务组热情周到的接待服务表示衷心的感谢，同时也预祝我院未来的发展更加美好。

来源：西安交通大学第二附属医院 2010-10-19