孟颂东——中国科学院微生物研究所病原微生物与免疫学院重点实验室研究员生物工程工程与技术科学创新人物科技创新网

孟颂东，博士，中科院微生物所病原微生物与免疫院重点实验室研究员、博士生导师。2007年，入选中科院“**计划”。主持参与科技部“973计划”“863计划”和国家科技重大专项以及国家自然科学基金委面上项目与重点项目。先后在Lancet、Hepatology、PNAS、Clinical Cancer Research、International Journal of Cancer、European Journal of Immunology等发表论文30余篇。

研究领域：

乙肝病毒免疫，肿瘤免疫，疫苗与免疫制剂

教育及工作经历：

1987 -1991 新疆大学生物系学士。

1991 -1994 中科院新疆生态与地理所硕士。

1995 -1998 中科院沈阳应用生态所博士。

1998 -2001 中科院微生物所分子病毒与免疫中心，博士后。

2002 -2007 美国西南医学中心肿瘤免疫中心，博士后，后转成Instructor。

2007 -迄今，中国科学院**计划引进人才，中科院微生物所病原微生物与免疫院重点实验室研究员、博士生导师。

学术兼职：

1、microRNA杂志的副主编。　

研究方向：

病毒、肿瘤免疫及疫苗研制。病毒与肿瘤免疫及靶向治疗。研究热休克蛋白在抗乙型肝炎病毒感染的作用机制，研制治疗慢性乙肝感染的综合性治疗方案；分析乳腺癌和慢性乙肝感染的肝癌肿瘤细胞的特异肿瘤抗原表达和基因突变，研究机体免疫系统对肿瘤细胞生长的免疫调控机制，为个体免疫治疗提供依据，并为肿瘤靶向药物开发提供新靶点。　

承担科研项目情况：

主持参与科技部“973计划”“863计划”和国家科技重大专项以及国家自然科学基金委面上项目与重点项目等。

1、973 项目（2007CB512802）。

2、863 项目（2006AA02A241）。

3、科技重大专项（2009ZX09503-007）。

科研成果：

在“973”、国家自然基金等项目的资助下，孟颂东课题组首次证明了gp96与来源于HBV的多肽直接结合，发现gp96在HBV感染的肝细胞中结合MHC I类分子限制性抗原肽，并对其结合的分子区域进行初步阐明，gp96蛋白Ｎ端是结合多肽的部位，为了解gp96激活T细胞的免疫机制奠定了基础。　　

gp96与参与抗原呈递的关键分子TAP、MHC I类分子直接相互作用，影响MHC-多肽复合物的形成，并将结合的抗原多肽呈递给抗原呈递细胞中MHC分子，激活特异性T细胞。同时gp96与TLR2/4相互作用，活化天然免疫，参与T细胞活化，利用TAT穿膜序列发现gp96进入抗原呈递细胞的效率直接影响其T细胞活化功能。上述研究揭示了重要病原通过抗原呈递的免疫放大机制，从理论上证实gp96作为通用T细胞疫苗佐剂的可行性。　　

miR-122在肝脏中有特异性表达，在肝脏功能和病理中发挥重要作用。孟颂东课题组通过对miR-122、miR-146a等miRNAs在HBV感染中的作用进行系统研究，发现HBV所有RNA/mRNA含有miR-122结合序列，通过“海绵”吸附的方式隔离并显著下调肝细胞中miR-122水平。miR-122的下调引发同样含有miR-122结合序列的宿主靶基因的表达上调，包括cyclin G1、PBF（PTTG1 binding factor）、NT5C3等。cyclin G1表达上调通过p53-病毒增强子使病毒复制增强，PBF/PTTG1通路的活化打破肝癌细胞休眠、从而引发肝癌，而NT5C3作为干扰素活化基因（ISGs）与IFN-α抗病毒治疗疗效密切相关。　　

上述研究发现HBV RNA/mRNA与宿主mRNA之间由于含有共同的miRNA反应(结合)序列而直接相互正向调控，揭示了病毒与宿主互作的新机制-竞争性病毒与宿主RNA（competitive viral and host RNAs, cvhRNAs）调控网络，对HBV持续感染、HCC发生及抗病毒产生了重要影响。此项研究也先后在Lancet, PNAS, Hepatology, Journal of Virology, Journal of Immunology, Scientific Reports, Molecular Oncology, Clinical Cancer Research, International Journal of Cancer, Vaccine等杂志共发表SCI论文30多篇。研究成果被Nature Immunology、Annual Review of Immunology、Hepatitis Monthly、Trends in Molecular Medicine 、Expert Review of Vaccines等引用报导，获得5项国家发明专利授权，孟颂东也因此被聘为microRNA杂志的副主编。　

1 热休克蛋白gp96作为新型疫苗佐剂在细胞免疫与体液免疫应答中的作用机制 孟颂东 中国科学院微生物研究所 2017

2 木本植物－微生物共生生态及应用技术研究张成刚;何兴元;杨思河;张忠泽;陈炜;韩桂云;姜波;田春杰;苏道岩;孟颂东;赵淑清;张粤;陈志骞中国科学院沈阳应用生态研究所 2000

3 三种重要肝病新机制、新标志物与无创诊断技术及策略的研究与应用赵景民;鲁凤民;孟颂东;南月敏;王艺瑾;邵金华;陈香梅;陈立钊;刘树红;王秋玲;姬军生;段惠娟解放军总医院第五医学中心 2018

发明公开：

[1]孟颂东,王子豪,张含,郑华国,鞠莹. 甲型流感病毒PB1蛋白T细胞表位多肽片段及其应用[P]. CN113527443A,2021-10-22.

[2]胡俊,孟颂东,杨哲,吴飙,杨博. PEG修饰的可抑制gp96的多肽、其制备方法及用途[P]. CN113121668A,2021-07-16.

[3]王刚,孟颂东,吕祥涛. 一种Gp96-多肽复合物(CTL-OT)的提取纯化方法[P]. CN112111016A,2020-12-22.

[4]王刚,孟颂东. 一种用于干细胞制备的无菌操作装置[P]. CN110479388A,2019-11-22.

[5]胡俊,孟颂东,杨哲,杨博,吴飚,丁筠. 具有抑制肿瘤功能的PEG化多肽及其制备方法与应用[P]. CN108864258A,2018-11-23.

[6]孟颂东,管泽良,丁筠,鞠莹. 重组TRA1蛋白在治疗肝衰竭的应用[P]. CN108578680A,2018-09-28.

[7]孟颂东,方敏,彭善鑫,王静,李长菲. 微RNA mmu-mir-487b-5p及类似物的应用和表达该微RNA载体的应用[P]. CN108374011A,2018-08-07.

[8]方敏,孟颂东,王静,彭善鑫,魏松涛. 微RNA hsa-mir-593-5p及其类似物的应用和表达该微RNA载体的应用[P]. CN108359725A,2018-08-03.

[9]方敏,孟颂东,王静,彭善鑫,魏松涛. 微RNA hsa-mir-127-3p及其类似物,以及表达该微RNA载体的应用[P]. CN108342388A,2018-07-31.

[10]孟颂东,方敏,彭善鑫,王静,李长菲. 微RNA hsa-mir-1-3p及其类似物的应用,和表达该微RNA载体的应用[P]. CN108113995A,2018-06-05.

[11]孟颂东,方敏,彭善鑫,王静,李长菲. 微RNA hsa-mir-486-5p及其类似物的应用和表达该微RNA载体的应用[P]. CN108079007A,2018-05-29.

[12]孟颂东,郑华国,李杨. 蛋白PACRGL及其多肽在制备治疗与预防癌症的药物中的应用[P]. CN107412727A,2017-12-01.

[13]孟颂东,李鑫,鞠莹. gp96蛋白在制备治疗特发性血小板减少性紫癜药物中的应用[P]. CN107019792A,2017-08-08.

[14]孟颂东,李鑫,鞠莹. 热休克蛋白gp96在治疗重症肌无力症中的应用[P]. CN106983855A,2017-07-28.

[15]孟颂东,李鑫,鞠莹. 热休克蛋白gp96在治疗自身免疫性溶血性贫血中的应用[P]. CN106975072A,2017-07-25.

[16]孟颂东,李鑫,鞠莹. 热休克蛋白gp96在治疗银屑病中的应用[P]. CN106943588A,2017-07-14.

[17]孟颂东,郑华国,李杨. 蛋白TIF1#β及其多肽在制备治疗与预防癌症的药物中的应用[P]. CN106913862A,2017-07-04.

[18]孟颂东,郑华国,李杨. NUP188蛋白及其多肽在治疗与预防癌症中的应用[P]. CN106913863A,2017-07-04.

[19]孟颂东,郑华国,李杨. APO#E蛋白及其多肽在治疗与预防癌症中的应用[P]. CN106890315A,2017-06-27.

[20]孟颂东,郑华国,李杨. DEF8蛋白及其多肽在治疗与预防癌症中的应用[P]. CN106822869A,2017-06-13.

[21]孟颂东,李鑫,鞠莹. 热休克蛋白gp96在治疗溃疡性结肠炎中的应用[P]. CN106620651A,2017-05-10.

[22]孟颂东,李长菲,王刚,吴博. 一种RNA抑制剂及其在肿瘤中的应用[P]. CN106434662A,2017-02-22.

[23]孟颂东,李长菲,王刚,吴博. 一种RNA抑制剂及其应用[P]. CN106381298A,2017-02-08.

[24]孟颂东,郑华国. 热休克蛋白gp96在治疗类风湿性关节炎中的应用[P]. CN106039287A,2016-10-26.

[25]孟颂东,李鑫,陈密. 热休克蛋白gp96在治疗系统性红斑狼疮中的应用[P]. CN105963681A,2016-09-28.

[26]孟颂东,王刚,李鑫. 一种血管内皮生长因子受体的CTL表位多肽及其应用[P]. CN105906706A,2016-08-31.

[27]孟颂东,王刚,李鑫. 一种人表皮生长因子受体的CTL表位多肽及其应用[P]. CN105820234A,2016-08-03.

[28]孟颂东,陈密,郑华国. 热休克蛋白gp96在预防和治疗1型糖尿病中的应用[P]. CN105749251A,2016-07-13.

[29]孟颂东,侯军委,刘炜炜,邓蒙蒙,陈立钊. 一种gp96蛋白和PD1抗体的偶联物的制备方法及其应用[P]. CN105194668A,2015-12-30.

[30]孟颂东,赵报,刘炜炜,邓蒙蒙,陈立钊. 一种人热休克蛋白gp96的制备方法及其应用[P]. CN104372025A,2015-02-25.

[31]孟颂东,侯军委,桂明明,赵报,陈立钊. 一种人热休克蛋白gp96的scFv抗体及其制备方法与应用[P]. CN104356233A,2015-02-18.

[32]孟颂东,初骁宇,陈立钊. 一种重组融合蛋白TAT-p53及其编码基因与应用[P]. CN104356240A,2015-02-18.

[33]孟颂东,桂明明,赵报. 人热休克蛋白gp96在制备筛查肝病的产品中的应用[P]. CN104330570A,2015-02-04.

[34]孟颂东,李鑫,孙璐,桂明明,张小俊,侯军伟,陈立钊. 一组具有结合gp96蛋白的能力的化合物及其在抗乳腺癌中的应用[P]. CN103570717A,2014-02-12.

[35]孟颂东,鞠莹,胡俊,陈立钊,李长菲,赵报. 一种具有广谱交叉保护能力的流感通用疫苗及其制备方法[P]. CN103505725A,2014-01-15.

[36]孟颂东,李鑫,李长菲,陈立钊,胡坤,武尔杰,赵报,鞠莹. gp96蛋白的抗体在制备癌细胞抑制剂中的应用[P]. CN103372209A,2013-10-30.

[37]田波,潘煦文,孟颂东. 阻断HIV-1膜融合的小环型DNA重组载体及其应用[P]. CN103290049A,2013-09-11.

[38]孟颂东,郝军莉,李长菲,胡俊. 一种RNA及载体在制备预防和/或治疗肝癌产品中的应用[P]. CN103088061A,2013-05-08.

[39]孟颂东,陈立钊,胡坤,李杨,李鑫,闫晓丽. 一组gp96蛋白的多肽片段及其应用[P]. CN102827257A,2012-12-19.

[40]孟颂东,胡坤,陈立钊,王彦中,李星辉,赵报. 组织干细胞提取物及其制备方法和应用[P]. CN102727525A,2012-10-17.

[41]孟颂东,王赛锋,李扬,李星辉,刘振,邱立鹏,闫晓丽,陈立钊,胡坤. 乙肝治疗性疫苗[P]. CN102462840A,2012-05-23.

[42]孟颂东,李星辉,刘振,闫晓丽,王赛锋,李扬,邱立鹏,陈立钊,胡坤. 一种促进gp96蛋白的免疫活性的方法及其应用[P]. CN102462841A,2012-05-23.

[43]田波,孟颂东,高福. 乙肝病毒抗原多肽与热休克蛋白的复合物及其应用[P]. CN1316431A,2001-10-10.

[44]马金莲,孟颂东,杨玉锁. 一种高产的阿魏蘑菇栽培方法[P]. CN1221555,1999-07-07.

[45]关桂兰,杨玉锁,郭沛新,陈理,王卫平,覃楠,孟颂东,郭朝辉. 提高小麦、大麦、玉米等农作物产量的PG6微生物制剂[P]. CN1125046,1996-06-26.

[46]关桂兰,王卫平,杨玉锁,覃楠,陈理,孟颂东,郭朝辉. 活化根际土壤磷并有增产作用的PG1菌剂及其制备方法[P]. CN1111224,1995-11-08.

实用新型：

[1]孟颂东,林国威. 一种生物医药研磨装置[P]. CN217725797U,2022-11-04.

[2]孟颂东,杨博. 一种实验室用自动采样存样装置[P]. CN217738758U,2022-11-04.

[3]孟颂东,武岳,王子豪. 密封塞开启器[P]. CN217323316U,2022-08-30.

[4]孟颂东,武岳,程放. 密封塞开启器[P]. CN216808065U,2022-06-24.

[5]孟颂东,林国威. 一种生物冷藏装置[P]. CN215992524U,2022-03-11.

[6]刘长征,孟颂东,臧今楠,沈慧,郑媛媛,杨博,臧筑华. 一种病房内具有消毒功能的地面清洗装置[P]. CN211582949U,2020-09-29.

[7]刘长征,孟颂东,臧今楠,沈慧,郑媛媛,杨博,臧筑华. 一种病房内用便携式输液架[P]. CN210904363U,2020-07-03.

[8]刘长征,孟颂东,臧今楠,沈慧,郑媛媛,杨博,臧筑华. 一种生物实验室内试管的存放装置[P]. CN210906266U,2020-07-03.

[9]王刚,孟颂东. 一种用于干细胞制备的无菌操作装置[P]. CN210752732U,2020-06-16.

[10]臧今楠,王颖,郭利平,孟颂东,臧筑华,何彬,张娜. 一种基于生物技术的园林土壤环保修复装置[P]. CN208679322U,2019-04-02.

[11]臧今楠,王颖,郑媛媛,沈慧,杨博,孟颂东,臧筑华,张娜,王军. 一种基于生物技术的密封发酵装置[P]. CN208684921U,2019-04-02.

[12]臧今楠,王颖,郑媛媛,沈慧,杨博,孟颂东,臧筑华,张娜,王军. 一种基于生物技术用细胞培养的培养基制装置[P]. CN208684922U,2019-04-02.

[13]臧今楠,王颖,郑媛媛,沈慧,杨博,孟颂东,臧筑华,张娜,王军. 一种基于生物技术用细胞培养固定装置[P]. CN208684923U,2019-04-02.

[14]臧今楠,王颖,郑媛媛,沈慧,杨博,孟颂东,臧筑华,张娜,王军. 一种生物提纯技术用样本放置架[P]. CN208684925U,2019-04-02.

[15]臧今楠,王颖,郑媛媛,沈慧,杨博,孟颂东,臧筑华,张娜,王军. 一种用于生物提纯用样品的可调节置放架[P]. CN208684926U,2019-04-02.

[16]臧今楠,王颖,郑媛媛,沈慧,杨博,孟颂东,臧筑华,张娜,王军. 一种便于携带的生物提纯设备[P]. CN208684927U,2019-04-02.

[17]刘长征,孟颂东,臧今楠,沈慧,郑媛媛,杨博,臧筑华. 一种用于生物实验室中有害液体的密封装置[P]. CN208683468U,2019-04-02.

[18]臧今楠,王颖,郭利平,孟颂东,臧筑华,何彬,张娜. 一种生物医药制备用标本保存装置[P]. CN208595738U,2019-03-12.

[19]杨博,臧今楠,王梓铭,孟颂东,刘超,臧戌,臧筑华. 一种便于放置的医疗用品消毒储存柜[P]. CN208464700U,2019-02-05.

[20]杨博,臧今楠,王梓铭,孟颂东,刘超,臧戌,臧筑华. 一种便携式医用消毒设备[P]. CN208464708U,2019-02-05.

[21]周永燚,臧今楠,王梓铭,杨博,孟颂东,臧戌,臧筑华. 一种便携式野外生物细胞提纯装置[P]. CN207862326U,2018-09-14.

[22]杨博,臧今楠,王梓铭,孟颂东,刘超,臧戌,臧筑华. 一种可防风的酒精灯[P]. CN207797021U,2018-08-31.

[23]周永燚,臧今楠,王梓铭,杨博,孟颂东,臧戌,臧筑华. 一种可定量的生物提纯装置[P]. CN207169224U,2018-04-03.

[24]周永燚,臧今楠,王梓铭,杨博,孟颂东,臧戌,臧筑华. 一种植物叶片细胞液提取装置[P]. CN207169095U,2018-04-03.

[25]周永燚,臧今楠,王梓铭,杨博,孟颂东,臧戌,臧筑华. 一种植物内叶绿素的提取装置[P]. CN207169096U,2018-04-03.

[26]周永燚,臧今楠,王梓铭,杨博,孟颂东,臧戌,臧筑华. 一种绞碎离心式植物组织液提取装置[P]. CN207175918U,2018-04-03.

[27]周永燚,臧今楠,王梓铭,杨博,孟颂东,臧戌,臧筑华. 一种便携式生物细胞恒温培养装置[P]. CN207175968U,2018-04-03.

[28]杨博,臧今楠,王梓铭,孟颂东,刘超,臧戌,臧筑华. 一种便于收集存放的生物实验室用防摔三角瓶[P]. CN207153727U,2018-03-30.

[29]杨博,臧今楠,王梓铭,孟颂东,刘超,臧戌,臧筑华. 一种生物实验室用移动式分类置物架[P]. CN207153741U,2018-03-30.

[30]杨博,臧今楠,王梓铭,孟颂东,刘超,臧戌,臧筑华. 一种便于固定的具有排水功能的生物实验室用试管架[P]. CN207153755U,2018-03-30.

[31]杨博,臧今楠,王梓铭,孟颂东,刘超,臧戌,臧筑华. 一种生物实验室用密封式真菌培养装置[P]. CN207159207U,2018-03-30.

[32]杨博,臧今楠,王梓铭,孟颂东,刘超,臧戌,臧筑华. 一种可全方位消毒的实验室用消毒设备[P]. CN207154334U,2018-03-30.

[33]杨博,臧今楠,王梓铭,孟颂东,刘超,臧戌,臧筑华. 一种空气净化装置[P]. CN207162763U,2018-03-30.

[34]杨博,臧今楠,王梓铭,孟颂东,刘超,臧戌,臧筑华. 一种便捷空气净化设备[P]. CN207162796U,2018-03-30.

[35]杨博,臧今楠,王梓铭,孟颂东,刘超,臧戌,臧筑华. 一种易用加热装置[P]. CN207162524U,2018-03-30.

发明授权：

[1]方敏,孟颂东,王静,彭善鑫,魏松涛. 微RNA hsa-mir-127-3p及其类似物,以及表达该微RNA载体的应用[P]. CN108342388B,2021-03-30.

[2]孟颂东,郑华国,李杨. 蛋白PACRGL的多肽与热休克蛋白gp96形成的复合物在制备治疗与预防癌症的药物中的应用[P]. CN107412727B,2021-03-26.

[3]孟颂东,郑华国,李杨. 蛋白TIF1-β的多肽与热休克蛋白gp96形成的复合物在制备治疗与预防癌症的药物中的应用[P]. CN106913862B,2021-03-16.

[4]孟颂东,郑华国,李杨. DEF8蛋白的多肽与热休克蛋白gp96的复合物在制备治疗与预防癌症药物中的应用[P]. CN106822869B,2020-10-30.

[5]孟颂东,郑华国,李杨. NUP188蛋白的多肽与热休克蛋白gp96的复合物在制备治疗与预防癌症药物中的应用[P]. CN106913863B,2020-10-27.

[6]孟颂东,郑华国. 热休克蛋白gp96在治疗类风湿性关节炎中的应用[P]. CN106039287B,2019-12-31.

[7]孟颂东,李鑫,陈密. 热休克蛋白gp96在治疗系统性红斑狼疮中的应用[P]. CN105963681B,2019-09-06.

[8]孟颂东,郑华国,李杨. APO-E蛋白及其多肽在治疗与预防癌症中的应用[P]. CN106890315B,2019-09-06.

[9]孟颂东,侯军委,刘炜炜,邓蒙蒙,陈立钊. 一种gp96蛋白和PD1抗体的偶联物的制备方法及其应用[P]. CN105194668B,2019-03-26.

[10]孟颂东,王刚,李鑫. 一种人表皮生长因子受体的CTL表位多肽及其应用[P]. CN105820234B,2019-02-19.

[11]孟颂东,侯军委,桂明明,赵报,陈立钊. 一种人热休克蛋白gp96的scFv抗体及其制备方法与应用[P]. CN104356233B,2017-09-29.

[12]孟颂东,郝军莉,李长菲,胡俊. 一种RNA及载体在制备预防和/或治疗肝癌产品中的应用[P]. CN103088061B,2016-08-03.

[13]孟颂东,李鑫,孙璐,桂明明,张小俊,侯军伟,陈立钊. 一组具有结合gp96蛋白的能力的化合物及其在抗乳腺癌中的应用[P]. CN103570717B,2016-05-11.

[14]孟颂东,桂明明,赵报. 人热休克蛋白gp96在制备筛查肝病的产品中的应用[P]. CN104330570B,2016-03-16.

[15]孟颂东,鞠莹,胡俊,陈立钊,李长菲,赵报. 一种具有广谱交叉保护能力的流感通用疫苗及其制备方法[P]. CN103505725B,2015-06-24.

[16]田波,潘煦文,孟颂东. 阻断HIV-1膜融合的小环型DNA重组载体及其应用[P]. CN103290049B,2014-11-12.

[17]孟颂东,李鑫,李长菲,陈立钊,胡坤,武尔杰,赵报,鞠莹. gp96蛋白的抗体在制备癌细胞抑制剂中的应用[P]. CN103372209B,2014-09-17.

[18]孟颂东,胡坤,陈立钊,王彦中,李星辉,赵报. 组织干细胞提取物及其制备方法和应用[P]. CN102727525B,2014-06-18.

[19]孟颂东,王赛锋,李扬,李星辉,刘振,邱立鹏,闫晓丽,陈立钊,胡坤. 乙肝治疗性疫苗[P]. CN102462840B,2014-03-19.

[20]孟颂东,陈立钊,胡坤,李杨,李鑫,闫晓丽. 一组gp96蛋白的多肽片段及其应用[P]. CN102827257B,2013-10-23.

[21]张忠泽,张成刚,孙传宝,张舟,冯树,张惠文,朱可丽,李国才,张海宏,安海英,高永涛,苏振成,孟颂东. 二步发酵制备Vc前体的方法[P]. CN1117158C,2003-08-06.

[22]田波,孟颂东,高福. 乙肝病毒抗原多肽与热休克蛋白的复合物及其应用[P]. CN1107681C,2003-05-07.

[23]马金莲,孟颂东,杨玉锁. 一种阿魏蘑菇栽培方法[P]. CN1073339C,2001-10-24.

[24]关桂兰,王卫平,杨玉锁,覃楠,陈理,孟颂东,郭朝辉. 活化根际土壤磷并有增产作用菌剂及其制备方法[P]. CN1061964C,2001-02-14.

[25]关桂兰,杨玉锁,郭沛新,陈理,王卫平,覃楠,孟颂东,郭朝辉. 提高小麦、大麦、玉米等农作物产量的PG-(6)微生物制剂[P]. CN1040719C,1998-11-18.

先后在Lancet、Hepatology、PNAS、Clinical Cancer Research、International Journal of Cancer、European Journal of Immunology等发表论文七十余篇。

发表英文期刊论文：

[1] Yuxiu Xu, Erlong Liu, Xialin Xie, Jiuru Wang, Huaguo Zheng, Ying Ju, Lizhao Chen, Changfei Li, Xuyu Zhou, Zihai Li, Xin Li, Songdong Meng. Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases. iScience[J]. 2021, 24(12): 103445-,

[2] Rongguo Wei, Biyan Zhou, Shaohua Li, Debin Zhong, Boan Li, Jianqiu Qin, Liping Zhao, Lixian Qin, Jun Hu, Jiuru Wang, Shixiong Yang, Jingming Zhao, Songdong Meng. Plasma gp96 is a Novel Predictive Biomarker for Severe COVID-19. Microbiology Spectrum[J]. 2021, 9(3):

[3] Qian Li-Yuan; Li Chang-Fei; Luo Yun-Jing*; Meng Song-Dong*.Research Progress of The Role of Heat Shock Protein gp96 in Cancer Development and Progression.Progress in Biochemistry and Biophysics, 2021, 48(9): 993-1005.

[4] Zhang, Han; Zheng, Huaguo; Guo, Peng; Hu, Liuyi; Wang, Zihao; Wang, Jiuru; Ju, Ying; Meng, Songdong*, "Broadly Protective CD8 + T Cell Immunity to Highly Conserved Epitopes Elicited by Heat Shock Protein gp96-Adjuvanted Influenza Monovalent Split Vaccine". Journal of Virology.2021, 95(12): e00507-21.

[5] Guan, Zeliang, Ding, Yun, Liu, Yongai, Zhang, Yu, Zhao, Jingmin, Li, Changfei, Li, Zihai, Meng, Songdong. Extracellular gp96 is a crucial mediator for driving immune hyperactivation and liver damage. Scientific Reports. 2020, 10(1):12596. http://dx.doi.org/10.1038/s41598-020-69517-7.

[6] Liu, LanLan, Hou, Junwei, Xu, Yuxiu, Qin, Lijuan, Liu, Weiwei, Zhang, Han, Li, Yang, Chen, Mi, Deng, Mengmeng, Zhao, Bao, Hu, Jun, Zheng, Huaguo, Li, Changfei, Meng, Songdong. PD-L1 upregulation by IFN-alpha/gamma-mediated Stat1 suppresses anti-HBV T cell response. PLos One. 2020, 15(7):e0228302. https://www.webofscience.com/wos/woscc/full-record/WOS:000550068700002.

[7] Songdong Meng. PD-L1upregulation by IFN-a/r-mediated stat1 suppresses anti-HBV T cell response. PLOS ONE. 2020,

[8] Qian, Liyuan, Fan, Hongxia, Ju, Ying, Chen, Lizhao, Li, Xin, Ye, Xin, Luo, Yunjing, Li, Changfei, Meng, Songdong*. A peptide-based inhibitor of gp96 suppresses HBsAg expression and HBV replication by upregulation of p53. Journal of General Virology. 2019, 100(8): 1241-1252,

[9] Zheng, Huaguo; Liu, Lanlan; Zhang, Han; Kan, Fangming; Wang, Shuo; Li, Yang; Tian, Huaqin; Meng, Songdong*. Dendritic cells pulsed with placental gp96 promote tumor-reactive immune responses.. PLoS ONE[J]. 2019, 14(1):e0211490. https://doaj.org/article/91650ce685c14c8d8a7ab2b561813ec9.

[10] Li, Xin, Xu, Yuxiu, Ding, Yun, Li, Changfei, Zhao, Hong, Wang, Jiandong, Meng, Songdong*. Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer. Molecular Cancer. 2018, 17(1):113. https://doaj.org/article/9aa543fe90d444089d458217795d3d49.

[11] Zhao, Jingmin, Zhang, Yu, Meng, Songdong. Disease Progress-Associated Evolution of Hepatitis B Virus Core Protein Driven By CD8(+) T-Cell Responses. HEPATOLOGYnull. 2018, 68: 150A-151A, https://www.webofscience.com/wos/woscc/full-record/WOS:000446020500243.

[12] Zhang, Yu, Wu, Yan, Deng, Mengmeng, Xu, Dongping, Li, Xiaodong, Xu, Zhihui, Hu, Jun, Zhang, Han, Liu, Kefang, Zhao, Yingze, Gao, Feng, Bi, Shengli, Gao, George F, Zhao, Jingmin, Liu, William J, Meng, Songdong*. CD8(+) T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress. Journal of Virology. 2018, 92(17): https://www.webofscience.com/wos/woscc/full-record/WOS:000443012300043.

[13] Songdong Meng. CD8+ T-Cell Responses-Associated Evolution of Hepatitis B Virus Core Protein in Disease Progress. J Virol.2018,

[14] Peng, Shanxin, Wang, Jing, Wei, Songtao, Li, Changfei, Zhou, Kai, Hu, Jun, Ye, Xin, Yan, Jinghua, Liu, Wenjun, Gao, George F, Fang, Min, Meng, Songdong*. Endogenous Cellular MicroRNAs Mediate Antiviral Defense against Influenza A Virus. Molecular Therapy - Nucleic Acids. 2018, 10: 361-375, http://dx.doi.org/10.1016/j.omtn.2017.12.016.

[15] Zhang, Yu, Xu, Dongping, Meng, Songdong, Lu, Fengmin, Zhao, JingMin. Hepatitis B core-related antigen (HBcrAg) correlated with HBV serum viral markers and intrahepatic indicators in treatment-naive patients with acute and chronic HBV. HEPATOLOGYnull. 2017, 66: 785A-786A, https://www.webofscience.com/wos/woscc/full-record/WOS:000412089801610.

[16] Li, Xin, Wu, Bo, Chen, Lizhao, Ju, Ying, Li, Changfei, Meng, Songdong. Urokinase-type plasminogen activator receptor inhibits apoptosis in triple-negative breast cancer through miR-17/20a suppression of death receptors 4 and 5. ONCOTARGET[J]. 2017, 8(51): 88645-88657, https://www.webofscience.com/wos/woscc/full-record/WOS:000413585600036.

[17] Liu, William J, Lan, Jiaming, Liu, Kefang, Deng, Yao, Yao, Yanfeng, Wu, Shaolian, Chen, Hong, Bao, Lingling, Zhang, Haifeng, Zhao, Min, Wang, Qihui, Han, Lingxia, Chai, Yan, Qi, Jianxun, Zhao, Jincun, Meng, Songdong, Qin, Chuan, Gao, George F, Tan, Wenjie. Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8(+) T Cell Epitopes and Host MHC. JOURNAL OF IMMUNOLOGY[J]. 2017, 198(2): 873-882, https://www.webofscience.com/wos/woscc/full-record/WOS:000392405000036.

[18] Shuo Wang, Hongxia Fan, Yang Li, Huaguo Zheng, Xin Li, Changfei Li, Lizhao Chen, Ying Ju, Songdong Meng. CD133 epitope vaccine with gp96 as adjuvant elicits an antitumor T cell response against leukemia. Chinese Journal of Biotechnology[J]. 2017, 33(6): 1006-1017,

[19] Hong, Feng, Rachidi, Saleh Mohammad, Lundgren, Debbie, Han, David, Huang, Xiu, Zhao, Hongyu, Kimura, Yayoi, Hirano, Hisashi, Ohara, Osamu, Udono, Heichiiro, Meng, Songdong, Liu, Bei, Li, Zihai. Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90. PLOS ONE[J]. 2017, 12(1): https://doaj.org/article/8cc921265d2a4ee3a4d1c683cb44d165.

[20] Chu, Xiaoyu, Wu, Bo, Fan, Hongxia, Hou, Junwei, Hao, Junli, Hu, Jun, Wang, Baozhong, Liu, Guangze, Li, Changfei, Meng, Songdong*. PTD-fused p53 as a potential antiviral agent directly suppresses HBV transcription and expression. Antiviral Res. 2016, 127: 41-49, http://www.corc.org.cn/handle/1471x/2157548.

[21] Li, Changfei, Deng, Mengmeng, Hu, Jun, Li, Xin, Chen, Lizhao, Ju, Ying, Hao, Junli, Meng, Songdong*. Chronic inflammation contributes to the development of hepatocellular carcinoma by decreasing miR-122 levels. Oncotarget. 2016, 7(13): 17021-17034, https://www.webofscience.com/wos/woscc/full-record/WOS:000375692900130.

[22] Liu, Weiwei, Chen, Mi, Li, Xinghui, Zhao, Bao, Hou, Junwei, Zheng, Huaguo, Qiu, Lipeng, Li, Zihai, Meng, Songdong*. Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response. PLOS ONE[J]. 2016, 11(5):e0155202. https://doaj.org/article/be9161dd584a4f07b8319e533580e3ff.

[23] Ding, Y.; Zheng, H.; Feng, C.; Wang, B.; Liu, C.; Mi, K.; Cao, H.*; Meng, S.*. Heat shock protein gp96 enhances T cell responses and protective potential to Bacillus Calmette-Guérin vaccine. Scandinavian Journal of Immunology, 2016, 84(4): 222-228.

[24] Deng, Mengmeng, Hou, Junwei, Hu, Jun, Wang, Shuo, Chen, Mi, Chen, Lizhao, Ju, Ying, Li, Changfei, Meng, Songdong*. Hepatitis B virus mRNAs functionally sequester let-7a and enhance hepatocellular carcinoma. Cancer Letters. 2016, 383(1): 62-72, http://dx.doi.org/10.1016/j.canlet.2016.09.028.

[25] Sheng ChunHai, Sun Lu, Chu XiaoYu, Li ChangFei, Meng SongDong. Heat Shock Protein gp96 3 ' UTR Functions as A ceRNA in Promoting DOHH Expression via miR-642a. Progress in Biochemistry and Biophysics. 2016, 43(10): 990-996, http://www.corc.org.cn/handle/1471x/2159225.

[26] Songdong Meng. A C/EBPα-miR-122 inflammatory feedback circuit enhances hepatocellular carcinoma development.. Oncotarget. 2016,

[27] Li, Xin, Wang, Baozhong, Liu, Weiwei, Gui, Mingming, Peng, Zheng, Meng, Songdong. Blockage of Conformational Changes of Heat Shock Protein gp96 on Cell Membrane by a alpha-Helix Peptide Inhibits HER2 Dimerization and Signaling in Breast Cancer. PLOS ONE[J]. 2015, 10(4): http://www.corc.org.cn/handle/1471x/2201420.

[28] Junwei Hou, Mengmeng Deng, Xin Li, Weiwei Liu, Xiaoyu Chu, Jing Wang, Feng Chen, Songdong Meng. Chaperone gp96 mediates ER-α36 cell membrane expression. Oncotarget. 2015, 6(31): 31857-31867, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741645/.

[29] Xin Li, Baozhong Wang, Weiwei Liu, Mingming Gui, Zheng Peng, Songdong Meng. Blockage of conformational changes of heat shock protein gp96 on cell membrane by a α-helix peptide inhibits HER2 dimerization and signaling in breast cancer.. PLos One. 2015, 10(4): e0124647.

[30] Wu, Bo, Chu, Xiaoyu, Feng, Cong, Hou, Junwei, Fan, Hongxia, Liu, Ningning, Li, Changfei, Kong, Xianping, Ye, Xin, Meng, Songdong*. Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer. Cancer Letters. 2015, 359(2): 325-334, http://www.corc.org.cn/handle/1471x/2156254.

[31] Li, Xin, Sun, Lu, Hou, Junwei, Gui, Mingming, Ying, Jianming, Zhao, Hong, Lv, Ning, Meng, Songdong*. Cell membrane gp96 facilitates HER2 dimerization and serves as a novel target in breast cancer. International Journal of Cancer. 2015, 137(3): 512-524, https://www.webofscience.com/wos/woscc/full-record/WOS:000354639200003.

[32] Hu, Jun, Xu, Yaxing, Li, Changfei, Hao, Junli, Peng, Shanxin, Chu, Xiaoyu, Zhang, Dake, Xu, Dongping, Meng, Songdong*. A cross-talk between Hepatitis B virus and host mRNAs confers viral adaptation to liver. Scientific Reports. 2015, 5: 10572. https://www.webofscience.com/wos/woscc/full-record/WOS:000358035500001.

[33] Hou, Junwei, Deng, Mengmeng, Li, Xin, Liu, Weiwei, Chu, Xiaoyu, Wang, Jing, Chen, Feng, Meng, Songdong*. Chaperone gp96 mediates ER-alpha 36 cell membrane expression. Oncotarget. 2015, 6(31): 31857-31867, https://www.webofscience.com/wos/woscc/full-record/WOS:000363185200118.

[34] Hou, Junwei, Li, Xin, Li, Changfei, Sun, Lu, Zhao, Yulai, Zhao, Jingmin, Meng, Songdong*. Plasma membrane gp96 enhances invasion and metastatic potential of liver cancer via regulation of uPAR. Molecular Oncology. 2015, 9(7): 1312-1323, http://dx.doi.org/10.1016/j.molonc.2015.03.004.

[35] Li, Changfei, Hu, Jun, Hao, Junli, Zhao, Bao, Wu, Bo, Sun, Lu, Peng, Shanxin, Gao, George F, Meng, Songdong*. Competitive virus and host RNAs: the interplay of a hidden virus and host interaction. Protein & Cell. 2014, 5(5): 348-356, https://www.webofscience.com/wos/woscc/full-record/WOS:000334936000005.

[36] Ju, Ying, Fan, Hongxia, Liu, Jun, Hu, Jun, Li, Xinghui, Li, Changfei, Chen, Lizhao, Gao, Qiang, Gao, George F, Meng, Songdong*. Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine. Vaccine. 2014, 32(23): 2703-2711, http://dx.doi.org/10.1016/j.vaccine.2014.03.045.

[37] Sun, Lu, Zhang, Yu, Zhao, Bao, Deng, Mengmeng, Liu, Jun, Li, Xin, Hou, Junwei, Gui, Mingming, Zhang, Shuijun, Li, Xiaodong, Gao, George F, Meng, Songdong*. A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes. Protein & Cell. 2014, 5(4): 317-327, https://www.webofscience.com/wos/woscc/full-record/WOS:000334428400008.

[38] Peng Zheng, Li ChangFei, Hao JunLi, Meng SongDong. Mechanisms and Therapeutic Strategies of Chronic Infection and Inflammation-Associated Hepatocellular Carcinoma. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2014, 41(1): 17-23, https://www.webofscience.com/wos/woscc/full-record/WOS:000330203100004.

[39] Peng Zheng, Li ChangFei, Hao JunLi, Meng SongDong*. Mechanisms and Therapeutic Strategies of Chronic Infection and Inflammation-Associated Hepatocellular Carcinoma. Progress in Biochemistry and Biophysics. 2014, 41(1): 17-23, https://www.webofscience.com/wos/woscc/full-record/WOS:000330203100004.

[40] Zhao, Bao, Li, Xin, Wang, Beinan, Gao, Bin, Meng, Songdong*. Prophylactic cancer vaccine, from concept to reality?. Chinese Science Bulletin. 2014, 59(10): 944-949, https://www.webofscience.com/wos/woscc/full-record/WOS:000333023100003.

[41] Zhao, Bao, Wang, Yanzhong, Wu, Bo, Liu, Shan, Wu, Erjie, Fan, HongXia, Gui, MingMing, Chen, Lizhao, Li, Changfei, Ju, Ying, Zhang, Wei, Meng, Songdong*. Placenta-derived gp96 as a multivalent prophylactic cancer vaccine. SCIENTIFIC REPORTS[J]. 2013, 3: 1947. https://www.webofscience.com/wos/woscc/full-record/WOS:000319960300001.

[42] Wang, Saifeng, Zhang, Xiaojun, Ju, Ying, Zhao, Bao, Yan, Xiaoli, Hu, Jun, Shi, Lei, Yang, Lebing, Ma, Zhibo, Chen, Lizhao, Liu, Yali, Duan, Zhongping, Chen, Xinyue, Meng, Songdong*. MicroRNA-146a Feedback Suppresses T Cell Immune Function by Targeting Stat1 in Patients with Chronic Hepatitis B. The Journal of Immunology. 2013, 191(1): 293-301, https://www.webofscience.com/wos/woscc/full-record/WOS:000320765000034.

[43] Li, Changfei, Wang, Yanzhong, Wang, Saifeng, Wu, Bo, Hao, Junli, Fan, Hongxia, Ju, Ying, Ding, Yuping, Chen, Lizhao, Chu, Xiaoyu, Liu, Wenjun, Ye, Xin, Meng, Songdong*. Hepatitis B Virus mRNA-Mediated miR-122 Inhibition Upregulates PTTG1-Binding Protein, Which Promotes Hepatocellular Carcinoma Tumor Growth and Cell Invasion. Journal of Virology. 2013, 87(4): 2193-2205, https://www.webofscience.com/wos/woscc/full-record/WOS:000314072000025.

[44] Zhang, Yu, Ren, Yulin, Wu, Yan, Zhao, Bao, Qiu, Lipeng, Li, Xiaodong, Xu, Dongping, Liu, Jun, Gao, George F, Meng, Songdong*. The L60V Variation in Hepatitis B Virus Core Protein Elicits New Epitope-Specific Cytotoxic T Lymphocytes and Enhances Viral Replication. Journal of Virology. 2013, 87(14): 8075-8084, https://www.webofscience.com/wos/woscc/full-record/WOS:000321017700027.

[45] Chen, Caiwei, Li, Jing, Bi, Yuhai, Yang, Limin, Meng, Shanshan, Zhou, Yuancheng, Jia, Xiaojuan, Meng, Songdong, Sun, Lei, Liu, Wenjun. Synthetic B- and T-cell epitope peptides of porcine reproductive and respiratory syndrome virus with Gp96 as adjuvant induced humoral and cell-mediated immunity. VACCINE[J]. 2013, 31(14): 1838-1847, http://dx.doi.org/10.1016/j.vaccine.2013.01.049.

[46] Hongxia Fan, Xiaoli Yan, Yu Zhang, Xiaojun Zhang, Yanzhou Gao, Yaxing Xu, Fusheng Wang, Songdong Meng. Increased expression of Gp96 by HBx-inducedNF-kappa B Activation Feedback Enhances Hepatitis B Virus Production. PLos One. 2013, 8(6): https://doaj.org/article/8a3024e160814ec48a83166b449c0e7c.

[47] Li, Xinghui, Liu, Zhen, Yan, Xiaoli, Zhang, Xiaojun, Li, Yang, Zhao, Bao, Wang, Shengdian, Zhou, Xuyu, Gao, George F, Meng, Songdong. Induction of Regulatory T Cells by High-Dose gp96 Suppresses Murine Liver Immune Hyperactivation. PLos One. 2013, 8(7): https://doaj.org/article/17ebb4e46790479abee023d23227ea27.

[48] Songdong Meng. HBV mRNAs-mediated miR-122 inhibition up-regulates PTTG1-binding protein which promotes HCC tumor growth and cell invasion.. Journal of Virology. 2013

[49] Zhao, Bao, Wang, Yanzhong, Zhang, Yu, Li, Yang, Zhang, Xiaojun, Xu, Yaxing, Chen, Lizhao, Li, Changfei, Ju, Ying, Meng, Songdong*. TAT-mediated gp96 transduction to APCs enhances gp96-induced antiviral and antitumor T cell responses. Vaccine. 2013, 31(3): 545-552, http://dx.doi.org/10.1016/j.vaccine.2012.11.011.

[50] Songdong Meng. The L60V variation in HBV core protein elicits new epitope-specific cytotoxic T lymphocytes and enhances viral replication. Journal of Virology. 2013,

[51] Hao, Junli, Jin, Wensong, Li, Xinghui, Wang, Saifeng, Zhang, Xiaojun, Fan, Hongxia, Li, Changfei, Chen, Lizhao, Gao, Bin, Liu, Guangze, Meng, Songdong*. Inhibition of Alpha Interferon (IFN-alpha)-Induced MicroRNA-122 Negatively Affects the Anti-Hepatitis B Virus Efficiency of IFN-alpha. Journal of Virology. 2013, 87(1): 137-147, https://www.webofscience.com/wos/woscc/full-record/WOS:000312455500011.

[52] Songdong Meng. IFN-α-induced miR-122 inhibition negatively affects the anti-HBV efficiency of IFN-α.. 2013, [[["https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKI4TPwAUKfiQHF-GpnOO1Am0jlsDKtI1Lkz4xc-QV28rgHzEqx-q6BpiyAlkmhsxAgLKFoSaQEdr&uniplatform=NZKPT"]]].

[53] Fan, Hongxia, Yan, Xiaoli, Zhang, Yu, Zhang, Xiaojun, Gao, Yanzhou, Xu, Yaxing, Wang, Fusheng, Meng, Songdong. Increased Expression of Gp96 by HBx-Induced NF-kappa B Activation Feedback Enhances Hepatitis B Virus Production. PLOS ONE[J]. 2013, 8(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000320755400045.

[54] Songdong Meng. Loss of MiR-122 Expression in Patients with Hepatitis B Enhances Hepatitis B Virus Replication through Cyclin G1 Modulated P53 Activity.. 2012,

[55] Wang, Yetao, Tong, Xiaomei, Omoregie, Ehimwenma Sheena, Liu, Wenjun, Meng, Songdong, Ye, Xin. Tetraspanin 6 (TSPAN6) Negatively Regulates Retinoic Acid-inducible Gene I-like Receptor-mediated Immune Signaling in a Ubiquitination-dependent Manner. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2012, 287(41): 34626-34634, http://dx.doi.org/10.1074/jbc.M112.390401.

[56] Wang, Saifeng, Qiu, Lipeng, Yan, Xiaoli, Jin, Wensong, Wang, Yanzhong, Chen, Lizhao, Wu, Erjie, Ye, Xin, Gao, George F, Wang, Fusheng, Chen, Yu, Duan, Zhongping, Meng, Songdong*. Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activity. Hepatology. 2012, 55(3): 730-741, https://www.webofscience.com/wos/woscc/full-record/WOS:000300699900010.

[57] Hu, Jun, Xu, Yaxing, Hao, Junli, Wang, Saifeng, Li, Changfei, Meng, Songdong*. MiR-122 in hepatic function and liver diseases.Protein & Cell. 2012, 3(5): 364-371, https://www.webofscience.com/wos/woscc/full-record/WOS:000310528300006.

[58] Yan, Xiaoli, Zhang, Xiaojun, Wang, Yanzhong, Li, Xinghui, Wang, Saifeng, Zhao, Bao, Li, Yang, Ju, Ying, Chen, Lizhao, Liu, Wenjun, Meng, Songdong*. Regulatory T-cell depletion synergizes with gp96-mediated cellular responses and antitumor activity. CANCER IMMUNOLOGY IMMUNOTHERAPY[J]. 2011, 60(12): 1763-1774, https://www.webofscience.com/wos/woscc/full-record/WOS:000297342400010.

[59] Yan, Xiaoli, Zhang, Xiaojun, Wang, Yanzhong, Li, Xinghui, Wang, Saifeng, Zhao, Bao, Li, Yang, Ju, Ying, Chen, Lizhao, Liu, Wenjun, Meng, Songdong. Regulatory T-cell depletion synergizes with gp96-mediated cellular responses and antitumor activity. Cancer Immunology, Immunotherapy. 2011, 60(12): 1763-1774, https://www.webofscience.com/wos/woscc/full-record/WOS:000297342400010.

[60] Zhang Yudan, Cao Sheng, Meng Songdong, Gao, Fu. A strategy to produce monoclonal antibodies against gp96 by prime-boost regimen using endogenous protein and E. coli heterologously-expressed fragment. .Journal of Central South University of Technology,2011,18(06):1857-1864.http://lib.cqvip.com/Qikan/Article/Detail?id=40231943.

[61] Li, Yang, Song, Haolei, Li, Jin, Wang, Yanzhong, Yan, Xiaoli, Zhao, Bao, Zhang, Xiaojun, Wang, Saifeng, Chen, Lizhao, Qiu, Bingsheng, Meng, Songdong*. Hansenula polymorpha expressed heat shock protein gp96 exerts potent T cell activation activity as an adjuvant. JOURNAL OF BIOTECHNOLOGY[J]. 2011, 151(4): 343-349, http://dx.doi.org/10.1016/j.jbiotec.2010.12.006.

[62] Wang, Saifeng, Qiu, Lipeng, Liu, Guangze, Li, Yang, Zhang, Xiaojun, Jin, Wensong, Gao, George F, Kong, Xianping, Meng, Songdong*. Heat shock protein gp96 enhances humoral and T cell responses, decreases Treg frequency and potentiates the anti-HBV activity in BALB/c and transgenic mice. Vaccine. 2011, 29(37): 6342-6351, http://dx.doi.org/10.1016/j.vaccine.2011.05.008.

[63] Cao, Sheng, Li, Yang, Li, Jin, Li, ChangFei, Zhang, Wei, Yang, ZengQi, Meng, SongDong*. Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer. Oncology Reports. 2010, 23(2): 423-428, https://www.webofscience.com/wos/woscc/full-record/WOS:000273873500016.

[64] Qiu, Lipeng, Fan, Hongxia, Jin, Wensong, Zhao, Bao, Wang, Yanzhong, Ju, Ying, Chen, Lizhao, Chen, Yu, Duan, Zhongping, Meng, Songdong. miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV. Biochemical and Biophysical Research Communications. 2010, 398(4): 771-777, http://124.16.144.217/handle/311023/2470.

[65] Li, Changfei; Cao, Sheng; Liu, Zhen; Ye, Xin; Chen, Lizhao; Meng, Songdong. RNAi-mediated Downregulation of uPAR Synergizes with Targeting of HER2 Through ERK Pathway in Breast Cancer Cells.. International Journal of Cancer. 2010, 127(7): 1507-1516.

[66] Liu, Zhen, Li, Xinghui, Qiu, Lipeng, Zhang, Xiaojun, Chen, Lizhao, Cao, Sheng, Wang, Fusheng, Meng, Songdong*. Treg suppress CTL responses upon immunization with HSP gp96. European Journal of Immunology. 2009, 39(11): 3110-3120, http://124.16.144.217/handle/311023/1241.

[67] S. Meng; D. Tripathy; S. Shete; R. Ashfaq; H. Saboorian; B. Haley; E. Frenkel; D. Euhus; M. Leitch; C. Osborne; E. Clifford; S. Perkins; P. Beitsch; A. Khan; L. Morrison; D. Herlyn; L. W. Terstappen; N. Lane; J. Wang; J. Uhr.uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues.Proceedings of the National Academy of Sciences of the United States of America, 2006, 103(46): 17361-17365.

[68] T. Fehm; E. F. Solomayer; S. Meng; T. Tucker; N. Lane; J. Wang; G. Gebauer*. Methods for isolating circulating epithelial cells and criteria for their classification as carcinoma cells.Cytotherapy, 2005, 7(2): 171-85.

[69] S. Meng; D. Tripathy; E. P. Frenkel; S. Shete; E. Z. Naftalis; J. F. Huth; P. D. Beitsch; M. Leitch; S. Hoover; D. Euhus; B. Haley; L. Morrison; T. P. Fleming; D. Herlyn; L. W. Terstappen; T. Fehm; T. F. Tucker; N. Lane; J. Wang; J. W. Uhr.Circulating tumor cells in patients with breast cancer dormancy.Clinical Cancer Research, 2004, 10(24): 8152-8162.

[70] S. Meng; D. Tripathy; S. Shete; R. Ashfaq; B. Haley; S. Perkins; P. Beitsch; A. Khan; D. Euhus; C. Osborne; E. Frenkel; S. Hoover; M. Leitch; E. Clifford; E. Vitetta; L. Morrison; D. Herlyn; L. W. Terstappen; T. Fleming; T. Fehm; T. Tucker; N. Lane; J. Wang; J. Uhr.HER-2 gene amplification can be acquired as breast cancer progresses.Proceedings of the National Academy of Sciences of the United States of America, 2004, 101(25): 9393-9398.

[71] T. Fehm; A. Sagalowsky; E. Clifford; P. Beitsch; H. Saboorian; D. Euhus; S. Meng; L. Morrison; T. Tucker; N. Lane; B. M. Ghadimi; K. Heselmeyer-Haddad; T. Ried; C. Rao; J. Uhr*. Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant.Clinical Cancer Research, 2002, 8(7): 2073-2084.

[72] S. D. Meng; J. Song; Z. Rao; P. Tien; G. F. Gao.Three-step purification of gp96 from human liver tumor tissues suitable for isolation of gp96-bound peptides.J Immunol Methods, 2002, 264(1-2): 29-35.

[73] Meng Songdong, Wang Rong, Yang Huaiyi, Tian Bo, Huang Guocun. Cloning of Glutamate Dehydrogenase cDNA from Chlorella sorokinmna and Analysis of Transgenic Tobacco Plants. Acta Botanica Sinica[J]. 2002, 44(3): 318-324.

[74] Songdong Meng, Tong Gao, George F. Gao, Po Tien.HBV-specific peptide associated with heat-shock protein gp96.Lancet, 2001, 357(9255): 528-529.

发表中文论文：

[1]刘璐璐,高建伟,李长菲,武岳,孟颂东.PEG修饰有效提高热休克蛋白gp96抑制性多肽抗乳腺癌的功能[J].生物工程学报,2022,38(09):3363-3378.

[2]钱丽媛,李长菲,罗云敬,孟颂东*.甲胎蛋白在肝癌的诊断和治疗中的研究进展[J].生物工程学报,2021,37(09):3042-3060.

[3]钱丽媛,李长菲,罗云敬,孟颂东.热休克蛋白gp96在恶性肿瘤中的研究进展[J].生物化学与生物物理进展,2021,48(09):993-1005.

[4]郭鹏,李长菲,鞠莹,刘二龙,张含,胡俊,孟颂东.N-糖基化修饰对热休克蛋白gp96免疫学功能的影响[J].生物工程学报,2021,37(11):4036-4046.

[5]郭鹏,张含,李长菲,孟颂东.Toll样受体通路调节Tregs功能的研究进展[J].生物工程学报,2020,36(09):1701-1712.

[6]孟颂东.海纳百川，励志前行-纪念田波院士[J].微生物学报,2020,60(04):628.

[7]叶金统,孟颂东,朱晓东.双特异抗体的研究进展[J].生物工程学报,2020,36(01):33-43.

[8]王硕,范红霞,李杨,郑华国,李鑫,李长菲,陈立钊,鞠莹,孟颂东.CD133表位联合热休克蛋白佐剂疫苗引发抗白血病的免疫应答（英文）[J].生物工程学报,2017,33(06):1006-1017.

[9]陈密,李星辉,郑华国,孟颂东.高剂量热休克蛋白gp96通过激活调节性T细胞预防1型糖尿病[J].生物工程学报,2016,32(12):1685-1693.

[10]盛春海,孙璐,初骁宇,李长菲,孟颂东.热休克蛋白gp96 3′UTR作为ceRNA通过miR-642a调控DOHH的表达[J].生物化学与生物物理进展,2016,43(10):990-996. http://www.corc.org.cn/handle/1471x/2091911.

[11] 孟颂东. 热休克蛋白：肿瘤治疗的新希望. 知识就是力量. 2016, (03):8-9, http://lib.cqvip.com/Qikan/Article/Detail?id=667989916.

[12]彭善鑫,李长菲,孙璐,孟颂东.PTTG1通过P53促进HBV的复制[J].微生物学报,2015,55(07):935-941.

[13]冯聪,吴博,范红霞,李长菲,孟颂东.NF-κB激活gp96转录从而促进肝细胞生长、细胞周期进展和细胞转化[J].微生物学报,2014,54(10):1212-1220.

[14]桂明明,武慧英,孙璐,徐亚星,赵报,李鑫,李长菲,王希东,孟颂东.毕赤酵母表达gp96-scFv抗体及生物活性测定[J].生物工程学报,2014,30(04):595-604.

[15]彭正,李长菲,郝军莉,孟颂东.慢性感染非可控炎症引发肝癌的机制与治疗策略[J].生物化学与生物物理进展,2014,41(01):17-23.

[16]徐亚星,王彦中,赵报,张小俊,范红霞,李星辉,孟颂东.电转联合热休克蛋白佐剂疫苗引发抗HBV的免疫应答（英文）[J].生物工程学报,2013,29(12):1765-1775.

[17]李默晗,李逸,欧琨,甄兆敏,孟颂东,王若珺,初明.手机辐射对大肠杆菌生长影响作用的研究[J].现代生物医学进展,2013,13(28):5452-5455.

[18]郜衍周,范红霞,邱立鹏,孟颂东.IFN-α对gp96的上调降低其抗HBV的效率[J].微生物学报,2013,53(08):867-874.

[19]徐亚星,王赛锋,张小俊,孟颂东.热激蛋白gp96免疫学功能及在主动免疫治疗肿瘤和传染病中的应用[J].生物工程学报,2012,28(03):261-266. http://lib.cqvip.com/Qikan/Article/Detail?id=41242381.

[20]闫晓丽,李长菲,张小俊,鞠莹,赵报,孟颂东.体外大量制备新型gp96肿瘤疫苗及其诱导的特异性抗肿瘤免疫应答分析[J].生物工程学报,2011,27(11):1598-1605.

[21]陈才伟,贾晓娟,孟颂东,刘文军.Gp96蛋白的免疫学及其临床应用研究进展[J].生物工程学报,2011,27(05):704-711. http://lib.cqvip.com/Qikan/Article/Detail?id=37994744.

[22]王彦中,王赛锋,张小俊,李杨,赵世宇,孟颂东.热休克蛋白HSP70和gp96增强乙肝DNA疫苗的细胞和体液免疫应答[J].生物工程学报,2011,27(05):790-798.

[23]任玉林,张宇,邱立鹏,张小俊,陈煜,王福生,谢尧,高斌,段钟平,孟颂东.新型HLA-A2限制的B,C型HBV特异性CTL表位的筛选及鉴定[J].科学通报,2010,55(30):2915-2926.http://lib.cqvip.com/Qikan/Article/Detail?id=35969653.

[24]金文松,胡坤,杨日高,胡开辉,孟颂东.热休克蛋白-多肽复合物疫苗用于肿瘤治疗的研究进展[J].肿瘤防治研究,2010,37(08):963-966.http://lib.cqvip.com/Qikan/Article/Detail?id=35046383.

[25]李杨,王赛锋,王亚男,孟颂东.乙肝治疗性疫苗的研制与临床应用[J].生物技术通报,2010(04):33-37. http://lib.cqvip.com/Qikan/Article/Detail?id=33509970.

[26] 孟颂东. gp96新型乙肝治疗性疫苗. 中国科技成果. 2009, 10-10, http://lib.cqvip.com/Qikan/Article/Detail?id=32110809.

[27]刘振,崔玉东,孟颂东.联合使用低剂量环磷酰胺有效增强热休克蛋白gp96免疫佐剂功能[J].生物技术通报,2009(06):117-121. http://lib.cqvip.com/Qikan/Article/Detail?id=30577800.

[28]李长菲,操胜,孟颂东.肿瘤休眠机制与治疗靶点的发现[J].癌症,2009,28(05):555-558.http://lib.cqvip.com/Qikan/Article/Detail?id=30273433.

[29]张杰,殷勇,田波,孟颂东,张孝斌.人肾癌组织中热休克蛋白gp96-肽复合物提取、纯化及体外的免疫效应[J].中华实验外科杂志,2005(06):708-710.

[30]殷勇,张杰,田波,孟颂东,张孝斌.肾癌组织与正常肾组织中热休克蛋白gp96-肽复合物体外免疫效应比较[J].武汉大学学报(医学版),2005(02):143-146.

[31]李燕,孟颂东,陈溥言,高福,田波.马立克氏病毒感染的鸡肝脏肿瘤中热应激蛋白108含量的增高及其基因序列分析和表达的研究[J].自然科学进展,2003, 13(7): 698-702.http://lib.cqvip.com/Qikan/Article/Detail?id=8077012.

[32]黄国存,孟颂东,王荣,杨怀义,田波.小球藻NADP-谷氨酸脱氢酶的cDNA克隆及转基因烟草分析(英文)[J].Acta Botanica Sinica,2002(03):318-324http://lib.cqvip.com/Qikan/Article/Detail?id=6129301.

[33]孟颂东,关桂兰,黄锡坚.新疆土著大豆根瘤菌种群遗传结构的初步分析[J].微生物学通报,2001(06):10-14.

[34]韩继刚,孟颂东,叶寅,田波.藻类污染生物防治新策略[J].微生物学报,2001(03):381-385. .http://lib.cqvip.com/Qikan/Article/Detail?id=5294842.

[35]孟颂东,高福,田波.热休克蛋白-多肽复合物在肿瘤和传染性疾病免疫中的作用[J].生物工程学报,2000(04):425-428. http://lib.cqvip.com/Qikan/Article/Detail?id=4450174.

[36]韩生成,刘清利,孟颂东,杨怀义,田波.植物寄生线虫分子生物学和抗线虫基因工程策略的研究进展(综述)[J].农业生物技术学报,1999(04):395-400.

[37]孟颂东,关桂兰,王卫平,陈理,杨玉锁.根际微生物产生的植物激素对小麦生长的作用(简报)[J].植物生理学通讯,1998(06):427-429.

[38]孟颂东,张忠泽.应用GUS基因研究弗氏中华根瘤菌的结瘤及效果[J].应用生态学报,1997(06):595-598.

[39]关桂兰,陈理,孟颂东,孔爱琴.PG_6微生物制剂提高作物产量机理研究[J].干旱区研究,1996(04):38-41.

[40]孟颂东,关桂兰,覃楠.PG1和PG6微生物在小麦根际的定殖对植物生长的影响[J].干旱区研究,1995(03):85-89.

[41]关桂兰,陈理,孟颂东,孔爱琴,郭朝辉.能活化土壤磷的PC制剂在生产中应用[J].新疆农垦科技,1994(06):18-19.

会议论文：

[1]Zhang Yu; Xu Dongping; Meng Songdong; Lu Fengmin; Zhao Jing Min. Hepatitis B core-related antigen (HBcrAg) correlated with HBV serum viral markers and intrahepatic indicators in treatment-naive patients with acute and chronic HBV.68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, 2017-10-20 To 2017-10-24.

[2]张小俊; 孟颂东. HLA-A24和-A33限制性B、C型乙肝病毒核心蛋白T细胞表位的鉴定与评价[C].2010年中国科学院微生物研究所博士后学术年会暨第二届博谊论坛论文摘要集.2011:54.

[3] 李长菲; 孟颂东. RNAi下调uPAR表达可通过ERK通路增强HER2靶向治疗乳腺癌的效果[C].2010年中国科学院微生物研究所博士后学术年会暨第二届博谊论坛论文摘要集.2011:53.

[4]台培东; 孟颂东; 李培军. 元素丰度与其对生物毒性的关系[C].中国毒理学会——第一届全国中青年学者科技论坛论文（摘要）集.2004:29.

孟颂东团队在自身免疫疾病治疗的研究中取得新进展

发布时间：2022.01.05 　　

自身免疫性疾病是一大类慢性炎症性疾病，其主要特征是免疫系统失调和异常活化，对自身抗原的耐受能力降低或丧失，从而导致身体正常组织、器官的免疫损伤和病理。常见的自身免疫性疾病包括系统性红斑狼疮、多发性硬化症、强直性脊柱炎、1型糖尿病、类风湿关节炎等，严重危害身体健康。目前临床治疗药物只能缓解症状、提高患者生活质量和降低病死率，并不能从病因学角度根治疾病。患者不仅需要频繁和终生服药，而且毒副作用大。　　

调节性T细胞（Treg）是一类具有免疫抑制和调节作用的T细胞亚群，它可以抑制多种免疫细胞亚型的活化、增殖和分化，对维持机体免疫稳态和自身抗原的免疫耐受至关重要，其抑制功能的缺失或受损会导致严重的自身免疫性疾病和慢性炎症。然而，目前并没有针对Treg的药物用于临床治疗自身免疫疾病。　　

中国科学院微生物研究所的孟颂东团队十多年来长期从事热休克蛋白gp96免疫学功能研究。该团队近期研究发现，高剂量gp96免疫在系统性红斑狼疮Lyn-/-小鼠（SLE）模型中显示了明显的治疗效果，有效降低自身抗体滴度、滤泡辅助性T细胞和产生抗体的浆细胞水平。此外，gp96治疗可减轻小鼠自身免疫性脑脊髓炎（EAE）的发病和进展。机制研究发现gp96处理可显著增加Treg的比例、增殖能力和抑制功能，通过基因表达谱分析发现NF-κB家族成员p65和c-Rel是gp96增强Treg中Foxp3表达的关键转录因子。他们通过构建与Toll样受体（TLRs）结合部位的突变体gp96、TLR2敲除小鼠和Treg细胞特异性缺失MyD88小鼠，均证明gp96通过TLR2-MyD88介导的NF-κB信号通路激活了Treg细胞并诱导Foxp3表达。　　

该研究阐明了gp96介导的Treg激活的机制，验证了活化的Treg可有效抑制自身抗体和Th细胞诱导的自身免疫性疾病，为研发通过激活Treg治疗自身免疫性疾病的药物提供了依据。鉴于自体gp96蛋白已经用于临床肿瘤治疗并显示出良好的安全性，该团队前期已经建立了天然提取和重组表达gp96蛋白的关键技术，这为设计以gp96蛋白为基础的治疗自身免疫性疾病的新型药物提供了基础。　

热休克蛋白gp96活化Treg的机制　　　　

上述研究成果已于2021年12月在iScience期刊上发表，中国科学院微生物研究所博士生徐玉秀为第一作者，中国科学院微生物研究所孟颂东研究员、研究组的助理研究员李鑫为共同通讯作者。该研究得到了国家自然科学基金和中国科学院战略性先导科技专项（B类）项目的经费支持。　　

全文链接：https://doi.org/10.1016/j.isci.2021.103445

从基础科研到制定标准再到大众科普，来看看孟颂东团队是如何做闭环科研

2022-11-17

由新型冠状病毒(SARS-CoV-2)引起的2019冠状病毒病(COVID-19)已造成全球健康危机和巨大的社会和经济困境[1]。既往研究报告新冠病毒主要通过呼吸道飞沫或气溶胶颗粒在人与人之间传播[2,3]。然而，冷链从业人员也可能通过接触受污染的冷链食品而被感染，这些冷链食品包装的新冠病毒核酸检测呈阳性[4]。新冠病毒在21℃–23℃下的塑料和不锈钢上，可存活长达72小时[5]。在4℃和–20℃条件下，食物表面的新冠病毒即使在21天后仍具有传染性[6]。中国疾病预防控制中心曾报道，新冠病毒从冷链食品传播给人类[7]。因此，如何阻断新冠病毒潜在的冷链传播成为全球面临的挑战。

疫情当前，使命在肩，中国科学院微生物研究所孟颂东研究员带领课题组投入大量科研力量，在病毒灭活和快速检测方面开展科研攻关，为遏制疫情蔓延提供了科技支撑。科研团队的同志们不忘初心、勇挑重担、冲锋在前，在疫情危难时刻，急国家之所急，毅然放弃假期，加班加点奋斗在生物安全3级实验室，以忘我的拼搏精神攻坚克难，体现出强烈的爱国主义和使命担当精神。

▲孟颂东研究员在疫情期间仍奋斗在科研前线▲

从0到1，为理论转化为实际赋能

自疫情爆发以来，孟颂东团队紧抓时事热点，心系国家大是，为消除病毒贡献自己微薄之力。该团队前期研究发现，将高滴度新冠病毒在冷链温度下暴露于电子束辐射，证明2 kGy的辐射剂量可以将病毒滴度(以中位组织培养感染剂量TCID5计算)从104.5 TCID50/mL降低到0。接下来，使用人类冠状病毒OC43 (HCoV-OC43)作为新冠病毒的替代品，发现3 kGy的高能电子束辐射可使常见的包装材料(不锈钢、滤纸和塑料)上的病毒效价降低超过4 log单位。采用实时定量PCR (RT-qPCR)对新冠病毒E、N和ORF1ab基因进行检测，发现病毒的TCID50与RT-qPCR检测具有很强的相关性。然而，检测新冠病毒核酸无法区分辐射灭活和未经辐照病毒的活性，这提示我们基于细胞的病毒分析对评估病毒的失活效率至关重要。由于有效灭活新冠病毒的辐射剂量远远低于食品加工的安全上限(10 kGy)，我们的研究结果为设计基于辐射的方法去除冷链食品中的新冠病毒提供了基础[8]。

上述研究成果于2022年10月在Virologica Sinica期刊上发表文章Quantitative determination of the electron beam radiation dose for SARS-CoV-2 inactivation to decontaminate frozen food packaging，中国科学院微生物研究所博士研究生王子豪为第一作者，中国科学院微生物研究所孟颂东研究员为通讯作者。该研究得到了国家原子能机构项目、国家自然科学基金、中国科学院项目、佛山中国科学院产业技术研究院产业化创新团队项目、佛山市高水平医院建设“登峰计划”、广东省生物医学创新平台建设项目“肿瘤免疫生物治疗”项目资助。

参与制定相关标准，为行业赋能

近期，中国科学院微生物研究所孟颂东研究员和中国同位素与辐射行业协会共同制定《冷链食品表面的新型冠状病毒辐照灭活剂量要求》团体标准，该标准于2022年9月21日在中国同位素与辐射行业协会官方网站发布，12月1日起实施[9]。未来，孟颂东团队将继续开展新冠病毒辐射消杀研究，推动冷链食品新冠病毒防控辐射消杀工业化示范应用，为冷链食品消毒提供一种便捷、无害的技术手段。

▲《冷链食品表面的新型冠状病毒辐照灭活剂量要求》团体标准▲

从科研成果转化为实际应用，为科技成果转化赋能

孟颂东团队一直致力于将科研成果转化为实际应用，以团队前期的科研成果为基础，与同方威视合作进行冷链食品新冠病毒专用辐照消毒工厂设计及关键环节自动化硬件的研究、开发与制造。目前的辐照场所主要通过人工装卸辐照产品，难以避免人员暴露。现计划研究以高度自动化出发，包括：自动拆垛、码放的机械臂系统，质量厚度检测系统，配合条码识别的智能货物判断系统，以及机械臂的控制和机械的实现，传感器及软件的研制，智能传输线的设计及工艺实现。为国内外首次研发，具有自主知识产权，其实现的功能与现有辐照加工相同，但使用更加便捷、操作更加智能化，能够满足各种大量快速自动化消毒灭菌的要求，能够在辐照消杀自动化领域实现独有的核心技术。

目前该工厂正准备在全国海关冷链物流实际消毒作业中应用，消毒效果显著，为保障我国冷链物流贸易顺利开展发挥重要作用。

央视大科普，赋能新时代

今年以来，我国高度重视科普工作，强调“科技创新、科学普及是实现创新发展的两翼，要把科学普及放在与科技创新同等重要的位置”[10]，为新时代科普工作指明了前进方向、提供了根本遵循。

为深入贯彻落实上述重要指示精神和决策部署，中国科学院微生物研究所孟颂东研究员应CCTV–10科教频道邀请以“辐照灭病菌”为主题进行科普演讲，详细讲解钴60技术的可靠性和先进性[11]。

▲孟颂东研究员应CCTV–10科教频道邀请以“辐照灭病菌”为主题进行科普演讲▲

未来，孟颂东团队将奔赴科技创新的“星辰大海”，坚定不移地向科学技术的广度和深度进军，努力实现更多“从0到1”，再“从1到N”的突破，为我国科技事业作出贡献。

[1] Wang M.Y., Zhao R., Gao L.J., Gao X.F., Wang D.P., Cao J.M. SARS-CoV-2: structure, biology, and structure-based therapeutics development. Front. Cell. Infect. Microbiol. 2020;10:1–17.

[2] Liu W., Guan W., Zhong N. Strategies and advances in combating COVID-19 in China. Engineering (Beijing) 2020;6:1076–1084.

[3] Jarvis M.C. Aerosol transmission of SARS-CoV-2: physical principles and implications. Front. Public Health. 2020;8:1–8.

[4] Liu P., Yang M., Zhao X., Guo Y., Wang L., Zhang J. Cold-chain transportation in the frozen food industry may have caused a recurrence of COVID-19 cases in destination: successful isolation of SARS-CoV-2 virus from the imported frozen cod package surface. Biosaf Health. 2020;2:199–201.

[5] van Doremalen N., T B., Dh M., Mg H., A G., Bn W., A T., Jl H., Nj T., Si G., Jo L.-S., E de W., Vj M. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N. Engl. J. Med. 2020;382:1564–1567.

[6] Fisher D., Reilly A., Zheng A.K.E., Cook A.R., Anderson D.E. Seeding of outbreaks of covid-19 by contaminated fresh and frozen food. bioRxiv. 2020 doi: 10.1101/2020.08.17.255166. 2020.08.17.255166.

[7] Ma H., Wang Z., Zhao X., Han J., Zhang Y., Wang H., Chen C., Wang J., Jiang F., Lei J., Song J., Jiang S., Zhu S., Liu H., Wang D., Meng Y., Mao N., Wang Y., Zhu Z., Chen Z., Wang B., Song Q., Du H., Yuan Q., Xia D., Xia Z., Liu P., Wu Y.A., Feng Z., Gao R., Gao G.F., Xu W. vol. 3. China CDC Wkly; 2021. pp. 637–644. (Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans — Qingdao City, Shandong Province, China, September 2020).

[8] Wang Z, Liang Z, Wei R, Wang H, Cheng F, Liu Y, Meng S. Quantitative determination of the electron beam radiation dose for SARS-CoV-2 inactivation to decontaminate frozen food packaging. Virol Sin. 2022 Oct 26:S1995-820X(22)00182-1. doi: 10.1016/j.virs.2022.10.007. Epub ahead of print. PMID: 36309306; PMCID: PMC9605788.

[9] 关于发布《冷链食品表面的新型冠状病毒辐照灭活剂量要求》等7项团体标准的公告.(2022-09-21)

http://www.cira.net.cn/CN/newsinfo.aspx?NewsId=467&CateId=36&BaseInfoCateId=16

[10] 中国人大网. “要把科学普及放在与科技创新同等重要的位置”——全国人大常委会科学技术普及法执法检查侧记.(2022-09-07)

http://www.npc.gov.cn/npc/kgfb/202209/67860e9c845546008cd6c99e417b5c30.shtml

[11] 央视网.辐照灭病菌.(2022-09-05)

http://tv.cctv.com/2022/09/05/VIDEv7omOegAof5zmR8lNLvf220905.shtml