沈锡辉 西北农林科技大学生命科学学院教授

沈锡辉，西北农林科技大学生命科学学院教授、博导，国家杰出青年科学基金获得者，入选国家“万人计划”、科技部中青年科技创新领军人才推进计划和陕西省特支计划，旱区作物逆境生物学国家重点实验室学术骨干，“农业与环境微生物学研究团队”学术带头人，西北农林科技大学“青年英才培养计划”首届入选者。 

长期从事农业与环境微生物领域的前沿研究，在细菌六型分泌系统的离子转运与抗宿主天然免疫新功能研究、微生物-宿主-环境相互作用机制与调控研究、耐药菌防控新策略研究、污染物降解与生物修复、植物内共生微生物促作物抗旱抗逆机制研究等方面取得了比较突出的进展，以通讯作者在Nature Communications、PNAS、Cell Reports、PLoS Pathogens、mBio等国际著名期刊发表SCI论文50余篇。获授权专利6件。曾作为主要研究人员参加国家重大专项，973，863, 国家自然科学基金等项目的研究。 多次应邀在国际、国内学术会议做大会报告及分会场主旨报告。

教育及工作经历：

1994年获西北农业大学（现西北农林科技大学）农学系农学专业，学士学位。

1994-09至1997-06，西北农业大学基础科学系生化专业，硕士学位。

2001-09至2005-07，中国科学院微生物研究所，微生物学博士学位。

2005-07至2008-06，美国普度大学生物科学系， 细胞微生物，博士后。

1997-07至2001-08，湖北省Bt研究开发中心 科研部, 助理研究员

2008-06至2010-06，中科院武汉病毒所病毒学国家重点实验室副研究员。

2010-07至现在，西北农林科技大学生命科学学院教授、博导。 

学术兼职： 

1、兼任陕西省农业与环境微生物重点实验室副主任。

2、中国微生物学会普通微生物专业委员会委员。

3、中国遗传学会微生物遗传专业委员会委员。

4、中国农业生物技术学会微生物生物技术分会理事。

5、陕西省微生物协会理事。

6、国际期刊《Frontiers in Cellular and Infection Microbiology》 Associate Editor，《Applied and Environmental Microbiology》编委等。 

 

研究方向：

主要从事农业与环境微生物学研究，在细菌六型分泌系统的功能研究及效应蛋白鉴定、细菌生物膜形成及运动性调控、植物内共生微生物组及其对农作物的促生抗旱功能研究、芳香化合物降解机制等方面取得了比较突出的成绩， 包括 1）首次发现细菌六型分泌系统的离子转运功能，率先报道了一类离子结合型T6SS效应蛋白在离子转运和细菌抗环境胁迫及宿主营养免疫中发挥重要作用；2）以谷氨酸棒杆菌为模型系统揭示了分枝硫醇在细菌抗多重环境胁迫中的多样化作用机制；3）发现细菌鞭毛三型分泌系统伴侣蛋白FliS通过与FlgM相互作用而抑制其分泌，进而影响细菌鞭毛系统基因表达调控，从而揭示了鞭毛系统基因表达的关闭机制。　

承担科研项目情况： 

1. 国家自然科学基金杰出青年基金“微生物环境适应机制(31725003)”，2018-2022，主持。

2. 国家重点研发计划合成生物学专项“难降解有毒污染物智能生物降解体系”课题“难降解有毒污染物智能降解体系的设计与装配” （SQ2018YFA090024-03），2019-2024，主持。 

3. 陕西省“高层次人才特殊支持计划”科技创新领军人才，2019-2024，主持。 

4. 国家自然科学基金面上项目“细菌VI型分泌系统转运金属离子的功能及机制研究 (31670053)”，2017-2020，主持。 

5. 国家自然科学基金面上项目“谷氨酸棒杆菌对木质纤维素糖化液中酚类抑制物质的耐受机理研究(31270078)”， 2013-2016，主持。 

6. 国家自然科学基金面上项目“假结核耶尔森氏菌VI型分泌系统的动力学分泌机制研究(31170121)” ，2012-2015 ，主持。

7. 科技部863“新型农业微生物肥效制剂的创制(2013AA102802)”子课题，2013-2017，主持。 

8. 陕西省农业攻关计划“秸秆糖化液高效利用微生物细胞工厂的构建技术研究(2014K02-12-01)”， 2014-2016，主持。

发明公开：

[1]沈锡辉, 郭胜志, 王瑶, 贾思雨, 尹雁玲, 潘君风, 廖俊. 一种防治小麦茎基腐病的生防菌、生防菌剂及应用[P]. 陕西省: CN118406589A, 2024-07-30.

[2]沈锡辉, 郭胜志, 王瑶, 贾思雨, 尹雁玲, 张笑笑, 蒋欣燕, 李长富. 一种哈瓦斯假单胞菌、生防菌剂及应用[P]. 陕西省: CN118222449A, 2024-06-21.

[3]沈锡辉, 任兆锐, 何海洋, 朱玲芳, 李长富, 李书宇, 王瑶. 一种激活真菌沉默基因簇表达的方法[P]. 陕西省: CN118207236A, 2024-06-18.

[4]沈锡辉, 李长富, 朱玲芳, 魏志艳, 左煜昕, 王珂楠, 王瑶. 一种激活放线菌沉默次生代谢产物合成基因簇表达的方法[P]. 陕西省: CN117625430A, 2024-03-01.

[5]李丹萍, 刘永德, 刘海, 陈春磊, 张彦雄, 郝新伟, 沈锡辉, 毛婷婷. 一种解磷菌及其在盐碱地的应用[P]. 浙江省: CN115322923A, 2022-11-11.

[6]沈锡辉, 石振堃, 宋莉, 瞿熠晨, 解莹春, 寇春华, 徐磊, 王瑶. 假结核耶尔森氏菌效应蛋白及其应用[P]. 陕西省: CN114921438A, 2022-08-19.

[7]沈锡辉, 左煜昕, 朱玲芳, 刘雨琦, 余丹洋, 王柯楠. 一种假结核耶尔森氏菌抗真菌蛋白、应用及分离纯化方法[P]. 陕西省: CN114703166A, 2022-07-05.

[8]翁为民, 刘永德, 陈春磊, 刘海, 张彦雄, 郝新伟, 沈锡辉, 毛婷婷. 一株耐低温耐盐碱解磷菌及培养方法及其应用[P]. 浙江省: CN114634887A, 2022-06-17.

[9]沈锡辉, 杨亚东, 王瑶, 孙宇, 唐亚楠, 肖志博. 一种大肠杆菌突变体的构建方法及外膜囊泡的制备方法[P]. 陕西省: CN113755514A, 2021-12-07.

[10]沈锡辉, 李梦园, 朱玲芳, 徐磊, 李长富, 王潇, 刘钦萌, 杨亚东, 王瑶. 一种蛋白型锰离子螯合剂、免疫抑制剂及应用[P]. 陕西省: CN111569047A, 2020-08-25.

[11]沈锡辉, 潘君风, 宋莉, 徐磊, 张磊, 王瑶. 一种假结核耶尔森氏菌杀虫蛋白及其编码基因和应用[P]. 陕西: CN108586587A, 2018-09-28.

[12]沈锡辉, 李书宇, 张磊, 王瑶. 一株骆驼刺泛菌突变株PA11ZM1的筛选方法及其应用[P]. 陕西: CN108546652A, 2018-09-18.

[13]沈锡辉, 潘君风, 宋莉, 杨昶杏, 徐磊, 张磊, 王瑶. 一种假结核耶尔森氏菌抗真菌蛋白及其编码基因和应用[P]. 陕西: CN108486085A, 2018-09-04.

[14]张磊, 陈超琼, 辛凯芸, 沈锡辉. 一株促作物抗干旱的欧文氏菌新种及其应用[P]. 陕西: CN105754900A, 2016-07-13.

[15]张磊, 辛凯芸, 沈锡辉. 一株具有促植物抗干旱作用的克雷伯氏菌及其应用[P]. 陕西: CN105754901A, 2016-07-13.

[16]沈锡辉, 司美茹, 封严严, 王铁涛, 陈燦, 潘君风, 张磊, 王瑶. 一个新型细菌抗逆功能基因及其表达产物与应用[P]. 陕西: CN104878023A, 2015-09-02.

[17]沈锡辉, 崔博宇, 宋云洪, 司美茹, 王瑶. 一种制备增强型单体细菌荧光素酶luxAB的方法[P]. 陕西: CN104178463A, 2014-12-03.

[18]沈锡辉, 葛云辉, 刘应保, 司美茹, 刘翔, 韦林芳, 李梦琪, 李玉菲, 崔博宇, 王瑶. 一株可高效降解木质素的乙酸钙不动杆菌[P]. 陕西: CN104017753A, 2014-09-03.

[19]沈锡辉, 王瑶, 崔博宇, 宋云洪, 王铁涛, 刘应保, 司美茹. 基于细菌荧光素酶BRET技术检测蛋白质相互作用的方法[P]. 陕西: CN103616502A, 2014-03-05.

[20]王瑶, 崔博宇, 沈锡辉, 宋云洪, 刘应保. 增强型单体细菌荧光素酶基因luxAB及其应用[P]. 陕西: CN103160528A, 2013-06-19.

[21]刘双江, 吴建峰, 刘志培, 王保军, 姜成英, 沈锡辉. 一种降解对氯代硝基苯的睾丸酮丛毛单胞菌及其用途[P]. 北京: CN1616650, 2005-05-18.

[22]刘志培, 李习武, 刘双江, 杨惠芳, 贾省芬, 沈锡辉, 吴建峰. 一种产生生物乳化剂和降解多环芳烃的赤红球菌Em及用途[P]. 北京: CN1519312, 2004-08-11.

发明授权： 

[1]沈锡辉, 左煜昕, 朱玲芳, 刘雨琦, 余丹洋, 王柯楠. 一种假结核耶尔森氏菌抗真菌蛋白、应用及分离纯化方法[P]. 陕西省: CN114703166B, 2023-07-28.

[2]翁为民, 刘永德, 陈春磊, 刘海, 张彦雄, 郝新伟, 沈锡辉, 毛婷婷. 一株耐低温耐盐碱解磷菌及培养方法及其应用[P]. 浙江省: CN114634887B, 2023-07-04.

[3]沈锡辉, 杨亚东, 王瑶, 孙宇, 唐亚楠, 肖志博. 一种大肠杆菌突变体的构建方法及外膜囊泡的制备方法[P]. 陕西省: CN113755514B, 2023-06-16.

[4]李丹萍, 刘永德, 刘海, 陈春磊, 张彦雄, 郝新伟, 沈锡辉, 毛婷婷. 一种解磷菌及其在盐碱地的应用[P]. 浙江省: CN115322923B, 2023-06-13.

[5]沈锡辉, 李梦园, 朱玲芳, 徐磊, 李长富, 王潇, 刘钦萌, 杨亚东, 王瑶. 一种蛋白型锰离子螯合剂、免疫抑制剂及应用[P]. 陕西省: CN111569047B, 2023-02-10.

[6]张磊, 辛凯芸, 沈锡辉. 一株具有促植物抗干旱作用的克雷伯氏菌及其应用[P]. 陕西省: CN105754901B, 2020-07-07.

[7]沈锡辉, 潘君风, 宋莉, 杨昶杏, 徐磊, 张磊, 王瑶. 一种假结核耶尔森氏菌抗真菌蛋白及其编码基因和应用[P]. 陕西省: CN108486085B, 2020-05-05.

[8]沈锡辉, 潘君风, 宋莉, 徐磊, 张磊, 王瑶. 一种假结核耶尔森氏菌杀虫蛋白及其编码基因和应用[P]. 陕西省: CN108586587B, 2020-05-05.

[9]张磊, 陈超琼, 辛凯芸, 沈锡辉. 一株促作物抗干旱的欧文氏菌新种及其应用[P]. 陕西省: CN105754900B, 2020-04-17.

[10]沈锡辉, 崔博宇, 宋云洪, 司美茹, 王瑶. 一种制备增强型单体细菌荧光素酶luxAB的方法[P]. 陕西省: CN104178463B, 2017-06-20.

[11]沈锡辉, 葛云辉, 刘应保, 司美茹, 刘翔, 韦林芳, 李梦琪, 李玉菲, 崔博宇, 王瑶. 一株可降解木质素的乙酸钙不动杆菌[P]. 陕西省: CN104017753B, 2017-01-11.

[12]沈锡辉, 王瑶, 崔博宇, 宋云洪, 王铁涛, 刘应保, 司美茹. 基于细菌荧光素酶BRET技术检测蛋白质相互作用的方法[P]. 陕西省: CN103616502B, 2016-05-25.

[13]王瑶, 崔博宇, 沈锡辉, 宋云洪, 刘应保. 增强型单体细菌荧光素酶基因luxAB及其应用[P]. 陕西省: CN103160528B, 2014-06-11.

[14]刘双江, 吴建峰, 刘志培, 王保军, 姜成英, 沈锡辉. 一种降解对氯代硝基苯的睾丸酮丛毛单胞菌及其用途[P]. 北京市: CN1313598C, 2007-05-02.

[15]刘志培, 李习武, 刘双江, 杨惠芳, 贾省芬, 沈锡辉, 吴建峰. 一种产生生物乳化剂和降解多环芳烃的赤红球菌Em及用途[P]. 北京市: CN1223673C, 2005-10-19.

发表英文文章 (*为通讯作者)：  

[1]Li, Shuyu; Liu, Qinmeng; Duan, Chongyi; Li, Jialin; Sun, Hengxi; Xu, Lei; Yang, Qiao; Wang, Yao; Shen, Xihui*; Zhang, Lei*. c-di-GMP inhibits the DNA binding activity of H-NS in Salmonella.Nature Communications, 2023, 14(1): 7502.

[2]Wu, Tong; Guo, Sheng-Zhi; Zhu, Hai-Zhen; Yan, Lei; Liu, Zhi-Pei; Li, De-Feng; Jiang, Cheng-Ying; Corvini, Philippe Francois-Xavier; Shen, Xi-Hui*; Liu, Shuang-Jiang*.The sulfonamide-resistance dihydropteroate synthase gene is crucial for efficient biodegradation of sulfamethoxazole by Paenarthrobacter species.Applied Microbiology and Biotechnology, 2023, 107(18): 5813-5827.

[3]Hao, Xinwei; Wang, Xiao; Chen, Chunlei; Liu, Ruirui; Yin, Yanling; Yao, Jun; Xiao, Zhibo; Liu, Xiaozhen; Shen, Xihui*; Liu, Xingyu*.Synthetic bacterial communities reshape microbial communities and enhance nutrient supply in desertified land of Northwest China.Applied Soil Ecology, 2023, 189: 104972.

[4]Liu, Hai; Wei, Zhiyan; Li, Jiali; Liu, Xingyu; Zhu, Lingfang; Wang, Yao; Wang, Tietao*; Li, Changfu*; Shen, Xihui.A Yersinia T6SS Effector YezP Engages the Hemin Uptake Receptor HmuR and ZnuABC for Zn2+ Acquisition.Applied and Environmental Microbiology, 2023, 89(7).

[5]Wang, Xiao; Tang, Jingjing; Dang, Wen; Xie, Zhen; Zhang, Fuhua; Hao, Xinwei; Sun, Sihuai; Liu, Xuan; Luo, Yi; Li, Mengyuan; Gu, Yanchao; Wang, Yao; Chen, Qiwei*; Shen, Xihui*; Xu, Lei*.Isolation and Characterization of Three Pseudomonas aeruginosa Viruses with Therapeutic Potential.Microbiology Spectrum, 2023, 11(3): e04636-22.

[6]Liu, Yang; Wang, Hao; Qian, Xun; Gu, Jie; Chen, Weimin; Shen, Xihui; Tao, Shiheng; Jiao, Shuo*; Wei, Gehong*.Metagenomics insights into responses of rhizobacteria and their alleviation role in licorice allelopathy.Microbiome, 2023, 11(1): 109.

[7]Kong, Jia; Hu, Jinyao; Li, Jia; Zhang, Jiaxing; Shen, Yuhe; Yue, Tianli; Shen, Xihui; Wang, Yuefei*; Li, Zhonghong*; Xia, Yinqiang*.Rethreading Design of Ratiometric roGFP2 Mimetic Peptide for Hydrogen Peroxide Sensing.Analytical Chemistry, 2023, 95(21): 8284-8290.

[8]Kong, Jia*; Zhao, Shixuan; Han, Xue; Li, Wenxin; Zhang, Jiaxing; Wang, Yuefei; Shen, Xihui; Xia, Yinqiang*; Li, Zhonghong*.Quantitative Ratiometric Biosensors Based on Fluorescent Ferrocene-Modified Histidine Dipeptide Nanoassemblies.Analytical Chemistry, 2023, 95(11): 5053-5060.

[9]Gu, Yanchao; Tang, Jingjing; Zhang, Fuhua; Qu, Yichen; Zhao, Min; Li, Mengyuan; Xie, Zhen; Wang, Xiao; Song, Li; Jiang, Zhengfan; Wang, Yao*; Shen, Xihui*; Xu, Lei*.Manganese potentiates lipopolysaccharide-induced innate immune responses and septic shock.International Journal of Biological Macromolecules, 2023, 230: 123202.

[10]Wang, Zhuo; Song, Li; Liu, Xiaozhen; Shen, Xihui; Li, Xin*.Bacterial second messenger c-di-GMP: Emerging functions in stress resistance.Microbiological Research, 2023, 268: 127302.

[11]Lin, Jinshui; Yang, Jianshe; Cheng, Juanli; Zhang, Weipeng; Yang, Xu; Ding, Wei; Zhang, Heng; Wang, Yao; Shen, Xihui*.Pseudomonas aeruginosa H3-T6SS Combats H2O2 Stress by Diminishing the Amount of Intracellular Unincorporated Iron in a Dps-Dependent Manner and Inhibiting the Synthesis of PQS.International Journal of Molecular Sciences, 2023, 24(2): 1614.

[12]Wang, Dandan; Zhu, Lingfang; Zhen, Xiangkai; Yang, Daoyan; Li, Changfu; Chen, Yating; Wang, Huannan; Qu, Yichen; Liu, Xiaozhen; Yin, Yanling; Gu, Huawei; Xu, Lei; Wan, Chuanxing; Wang, Yao; Ouyang, Songying*; Shen, Xihui*.A secreted effector with a dual role as a toxin and as a transcriptional factor.Nature Communications, 2022, 13(1): 7779.

[13]Li, Shuyu; Sun, Hengxi; Li, Jianghan; Zhao, Yujiao; Wang, Ruiying; Xu, Lei; Duan, Chongyi; Li, Jialin; Wang, Zhuo; Liu, Qinmeng; Wang, Yao; Ouyang, Songying*; Shen, Xihui*; Zhang, Lei*.Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone.Nature Communications, 2022, 13(1): 6684.

[14]Liu, Xiaozhen; Liu, Qinmeng; Sun, Sihuai; Sun, Hengxi; Wang, Yao; Shen, Xihui*; Zhang, Lei*.Exploring AI-2-mediated interspecies communications within rumen microbial communities.Microbiome, 2022, 10(1): 167.

[15]Xu, Lei; Li, Mengyuan; Yang, Yadong; Zhang, Chen; Xie, Zhen; Tang, Jingjing; Shi, Zhenkun; Chen, Shukun; Li, Guangzhe; Gu, Yanchao; Wang, Xiao; Zhang, Fuhua; Wang, Yao; Shen, Xihui*.Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release.mBio, 2022, 13(3). 

[16]Wang, Zhuo; Xie, Xiaorong; Shang, Daohan; Xie, Laigong; Hua, Yueyue; Song, Li; Yang, Yantao; Wang, Yao; Shen, Xihui*; Zhang, Lei*.A c-di-GMP Signaling Cascade Controls Motility, Biofilm Formation, and Virulence in Burkholderia thailandensis.Applied and Environmental Microbiology, 2022, 88(7): e02529-21.

[17]Guo, Sheng-Zhi; Wu, Tong; Zhu, Hai-Zhen; Yan, Lei; Liu, Zhi-Pei; Li, De-Feng; Jiang, Cheng-Ying; Liu, Shuang-Jiang*; Shen, Xi-Hui*.Niabella beijingensis sp. nov. and Thermomonas beijingensis sp. nov., two bacteria from constructed wetland.International Journal of Systematic and Evolutionary Microbiology, 2022, 72(3): 005280.

[18]Wang Chenguang#; Xu Lei#; Zhu Lingfang#; Li Changfu; Li Mengyuan; Liu Qinmeng; Yang Wenhui; Pan Damin; Hu Lingfei; Yang Yadong; Lu Zhiqiang; Wang Yao; Zhou Dongsheng*; Jiang Zhengfan*; Shen Xihui*.T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese.Proc Natl Acad Sci U S A., 2021, 118(42): e2103526118.

[19]Lei Xu#; Jinshui lin#; Jianshe Yang; Zhuo Wang; Xihui Shen*.Beyond dueling: roles of the type VI secretion system in microbiome modulation, pathogenesis and stress resistance.Stress Biology, 2021, 1(1): 11.

[20]Li Changfu#; Zhu Lingfang#; Wang dandan#; Wei Zhiyan; Hao Xinwei; Wang Zhuo; Li Tengfei; Zhang Lei; Lu Zhiqiang; Long Mingxiu; Wang Yao*; Wei Gehong*; Shen Xihui*.T6SS secretes an LPS-binding effector to recruit OMVs for exploitative competition and horizontal gene transfer.ISME J, 2021, Online ahead of prin(.): ..

[21]Cai, Ran; Gao, Fen; Pan, Junfeng; Hao, Xinwei; Yu, Zonglan; Qu, Yichen; Li, Jialin; Wang, Dandan; Wang, Yao; Shen, Xihui; Liu, Xingyu*; Yang, Yantao*.The transcriptional regulator Zur regulates the expression of ZnuABC and T6SS4 in response to stresses in Yersinia pseudotuberculosis.Microbiological Research, 2021, 249: 126787.

[22]Li, Changfu; Pan, Damin; Li, Mengyuan; Wang, Yao; Song, Luting; Yu, Danyang; Zuo, Yuxin; Wang, Kenan; Liu, Yuqi; Wei, Zhiyan; Lu, Zhiqiang; Zhu, Lingfang*; Shen, Xihui*.Aerobactin-Mediated Iron Acquisition Enhances Biofilm Formation, Oxidative Stress Resistance, and Virulence of Yersinia pseudotuberculosis.Frontiers in Microbiology, 2021, 12: 699913.

[23]Song, Li; Pan, Junfeng; Yang, Yantao; Zhang, Zhenxing; Cui, Rui; Jia, Shuangkai; Wang, Zhuo; Yang, Changxing; Xu, Lei; Dong, Tao G.; Wang, Yao*; Shen, Xihui*.Contact-independent killing mediated by a T6SS effector with intrinsic cell-entry properties.Nature Communications, 2021, 12(1): 423.

[24]Luo, Yantao; Liu, Dongying; Jiao, Shuo; Liu, Shuang; Wang, Xinye; Shen, Xihui; Wei, Gehong*.Identification of Robinia pseudoacacia target proteins responsive to Mesorhizobium amphore CCNWGS0123 effector protein NopT.Journal of Experimental Botany, 2020, 71(22): 7347-7363.

[25]Zhang, Lei*; Li, Shuyu; Liu, Xiaozhen; Wang, Zhuo; Jiang, Mei; Wang, Ruiying; Xie, Laigong; Liu, Qinmeng; Xie, Xiaorong; Shang, Daohan; Li, Mengyun; Wei, Zhiyan; Wang, Yao; Fan, Chengpeng; Luo, Zhao-Qing*; Shen, Xihui*.Sensing of autoinducer-2 by functionally distinct receptors in prokaryotes.Nature Communications, 2020, 11(1): 5371.

[26]Zhang, Lei; Zhang, Weipeng; Li, Qiqi; Cui, Rui; Wang, Zhuo; Wang, Yao; Zhang, Yu-Zhong; Ding, Wei*; Shen, Xihui*.Deciphering the Root Endosphere Microbiome of the Desert Plant Alhagi sparsifolia for Drought Resistance-Promoting Bacteria.Applied and Environmental Microbiology, 2020, 86(11): e02863-19.

[27]Wang, Zhuo; Wang, Tietao; Cui, Rui; Zhang, Zhenxing; Chen, Keqi; Li, Mengyun; Hua, Yueyue; Gu, Huawei; Xu, Lei; Wang, Yao; Yang, Yantao*; Shen, Xihui*.HpaR, the Repressor of Aromatic Compound Metabolism, Positively Regulates the Expression of T6SS4 to Resist Oxidative Stress in Yersinia pseudotuberculosis.Frontiers in Microbiology, 2020, 11: 705. 

[28]Zhang, Bing; Gu, Huawei; Yang, Yantao; Bai, Haonan; Zhao, Chao; Si, Meiru; Su, Tao*; Shen, Xihui*.Molecular Mechanisms of AhpC in Resistance to Oxidative Stress in Burkholderia thailandensis.Frontiers in Microbiology, 2019, 10: 1483.

[29]Chen, Can; Yang, Xiaobing; Shen, Xihui*.Confirmed and Potential Roles of Bacterial T6SSs in the Intestinal Ecosystem.Frontiers in Microbiology, 2019, 10: 1484.

[30]Li, Shuyu; Liang, Hong; Wei, Zhiyan; Bai, Haonan; Li, Mengyun; Li, Qiqi; Qu, Meng; Shen, Xihui; Wang, Yao*; Zhang, Lei*.An Osmoregulatory Mechanism Operating through OmpR and LrhA Controls the Motile-Sessile Switch in the Plant GrowthPromoting Bacterium Pantoea alhagi.Applied and Environmental Microbiology, 2019, 85(10): UNSP e00077-19.

[31]Ma, Li; Zhou, Lizhen; Lin, Jinshui; Ji, Jiuyuan; Wang, Yang; Jiang, Haobo; Shen, Xihui; Lu, Zhiqiang*.Manipulation of the silkworm immune system by a metalloprotease from the pathogenic bacterium Pseudomonas aeruginosa.Developmental and Comparative Immunology, 2019, 90: 176-185. 

[32]Li, Changfu; Zhu, Lingfang; Pan, Damin; Li, Shuyu; Xiao, He; Zhang, Zhenxing; Shen, Xihui; Wang, Yao*; Long, Mingxiu*.Siderophore-Mediated Iron Acquisition Enhances Resistance to Oxidative and Aromatic Compound Stress in Cupriavidus necator JMP134.Applied and Environmental Microbiology, 2019, 85(1): UNSP e01938-18.

[33]Yang, Xiaobing; Pan, Junfeng; Wang, Yao; Shen, Xihui*.Type VI Secretion Systems Present New Insights on Pathogenic Yersinia.Frontiers in Cellular and Infection Microbiology, 2018, 8: 260. 

[34]Lin Jinshui*; Cheng Juanli; Wang Yao; Shen Xihui*.The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore.Frontiers in Cellular and Infection Microbiology, 2018, 8: 230.

[35]Zhang Lei*; Li Muhang; Li Qiqi; Chen Chaoqiong; Qu Meng; Li Mengyun; Wang Yao; Shen Xihui*.The Catabolite Repressor/Activator Cra Is a Bridge Connecting Carbon Metabolism and Host Colonization in the Plant Drought Resistance-Promoting Bacterium Pantoea alhagi LTYR-11Z.Applied and Environmental Microbiology, 2018, 84(13): UNSP e00054-18.

[36]Yang Xiaobing; Long Mingxiu; Shen Xihui*.Effector-Immunity Pairs Provide the T6SS Nanomachine its Offensive and Defensive Capabilities.Molecules, 2018, 23(5): 1009. 

[37]Dai, Qingyun; Xu, Lei; Xiao, Lu; Zhu, Kaixiang; Song, Yunhong; Li, Changfu; Zhu, Lingfang; Shen, Xihui*; Wang, Yao*.RovM and CsrA Negatively Regulate Urease Expression in Yersinia pseudotuberculosis.Frontiers in Microbiology, 2018, 9: 348.

[38]Zhang, Lei*; Li, Qiqi; Chen, Chaoqiong; Li, Xin; Li, Muhang; Hu, Jingjiang; Shen, Xihui*.Propioniciclava sinopodophylli sp nov., isolated from leaves of Sinopodophyllum hexandrum (Royle) Ying.INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2017, 67(10): 4111-4115.

[39]Xu, Yixiang; Wang, Chao; Zhang, Gang; Tian, Jingjing; Liu, Ying; Shen, Xihui*; Feng, Jie*.ISCR2 is associated with the dissemination of multiple resistance genes among Vibrio spp. and Pseudoalteromonas spp. isolated from farmed fish.ARCHIVES OF MICROBIOLOGY, 2017, 199(6): 891-896.

[40]Si, Meiru; Wang, Yao; Zhang, Bing; Zhao, Chao; Kang, Yiwen; Bai, Haonan; Wei, Dawei; Zhu, Lingfang; Zhang, Lei; Dong, Tao G.; Shen, Xihui*.The Type VI Secretion System Engages a Redox-Regulated Dual-Functional Heme Transporter for Zinc Acquisition.CELL REPORTS, 2017, 20(4): 949-959.

[41]Wang, Tietao; Chen, Keqi; Gao, Fen; Kang, Yiwen; Chaudhry, Muhammad Tausif; Wang, Zhuo; Wang, Yao*; Shen, Xihui*.ZntR positively regulates T6SS4 expression in Yersinia pseudotuberculosis.Journal of Microbiology, 2017, 55(6): 448-456. 

[42]Zhao Ruoxi; Song Yunhong; Dai Qingyun; Kang Yiwen; Pan Junfeng; Zhu Lingfang; Zhang Lei; Wang Yao; Shen Xihui.A starvation-induced regulator, RovM, acts as a switch for planktonic/biofilm state transition in Yersinia pseudotuberculosis.Scientific Reports, 2017, 7(1): 639.

[43]Lin, Jinshui; Zhang, Weipeng; Cheng, Juanli; Yang, Xu; Zhu, Kaixiang; Wang, Yao; Wei, Gehong; Qian, Pei-Yuan; Luo, Zhao-Qing; Shen, Xihui*.A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition.Nature Communications, 2017, 8: 14888.

[44]Zhang, Lei; Zhong, Jun; Liu, Hao; Xin, Kaiyun; Chen, Chaoqiong; Li, Qiqi; Wei, Yahong; Wang, Yao; Chen, Fei*; Shen, Xihui*.Complete genome sequence of the drought resistance-promoting endophyte Klebsiella sp LTGPAF-6F.Journal of Biotechnology, 2017, 246: 36-39. 

[45]Si, Meiru; Zhao, Chao; Burkinshaw, Brianne; Zhang, Bing; Wei, Dawei; Wang, Yao; Dong, Tao G.*; Shen, Xihui*.Manganese scavenging and oxidative stress response mediated by type VI secretion system in Burkholderia thailandensis.Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(11):E2233-E2242. (cited by Faculty of 1000 Prime) 

[46]Xin, Kaiyun; Li, Muhang; Chen, Chaoqiong; Yang, Xu; Li, Qiqi; Cheng, Juanli; Zhang, Lei*; Shen, Xihui*.Paenibacillus qinlingensis sp nov., an indole-3-acetic acid-producing bacterium isolated from roots of Sinopodophyllum hexandrum (Royle) Ying.International Journal of Systematic and Evolutionary Microbiology, 2017, 67(3): 589-595. 

[47]Chen, Can; Pan, Junfeng; Yang, Xiaobing; Xiao, He; Zhang, Yaoling; Si, Meiru; Shen, Xihui*; Wang, Yao*.Global transcriptomic analysis of the response of Corynebacterium glutamicum to ferulic acid.Archives of Microbiology, 2017, 199(2): 325-334.

[48]Chaoqiong; Kaiyun Xin; Hao Liu; Juanli Cheng; Xihui Shen; Yao Wang; Lei Zhang*.Pantoea alhagi, a novel endophytic bacterium with ability to improve growth and drought tolerance in wheat.Scientific Reports, 2017, 7: 41564.

[49]Meiru Si; Tietao Wang; Junfeng Pan; Jinshui Lin; Can Chen; Yahong Wei; Zhiqiang Lu; Gehong Wei; Xihui Shen*.Graded Response of the Multifunctional 2-Cysteine Peroxiredoxin, CgPrx, to Increasing Levels of Hydrogen Peroxide in Corynebacterium glutamicum.Antioxidants & Redox Signaling, 2017, 26(1): 1-14.

[50]Si, Meiru; Feng, Yanyan; Chen, Keqi; Kang, Yiwen; Chen, Can; Wang, Yao*; Shen, Xihui*.Functional comparison of methionine sulphoxide reductase A and B in Corynebacterium glutamicum.JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, 2017, 63(5): 280-286.

[51]Chen, Chaoqiong; Xin, Kaiyun; Li, Muhang; Li, Xin; Cheng, Juanli; Zhang, Lei*; Shen, Xihui*.Paenibacillus sinopodophylli sp nov., a siderophore-producing endophytic bacterium isolated from roots of Sinopodophyllum hexandrum (Royle) Ying.International Journal of Systematic and Evolutionary Microbiology, 2016, 66(12): 4993-4999.

[52]Chen, Can; Pan, Junfeng; Yang, Xiaobing; Guo, Chenghao; Ding, Wei; Si, Meiru; Zhang, Yi; Shen, Xihui*; Wang, Yao*.Global Transcriptomic Analysis of the Response of Corynebacterium glutamicum to Vanillin.PLos One, 2016, 11(10): e0164955.

[53]Sihuai Sun#; Xiaobing Yang#; Yao Wang; Xihui Shen*.In Vivo Analysis of Protein-Protein Interactions with Bioluminescence Resonance Energy Transfer (BRET): Progress and Prospects.Int J Mol Sci., 2016, 17(10): pii: E1704.

[54]Liang, Jianqiang; Zhang, Mingzhe; Lu, Mingmei; Li, Zhefei; Shen, Xihui; Chou, Minxia*; Wei, Gehong*。Functional characterization of a csoR-cueA divergon in Bradyrhizobium liaoningense CCNWSX0360, involved in copper, zinc and cadmium cotolerance.Scientific Reports, 2016, 6: 35155.

[55]Shi, Xu; Li, Changfu; Zhao, Liang; Si, Meiru; Zhu, Lingfang; Xin, Kaiyun; Chen, Chaoqiong; Wang, Yao; Shen, Xihui; Zhang, Lei*.Rhizobium gei sp nov., a bacterial endophyte of Geum aleppicum.International Journal of Systematic and Evolutionary Microbiology, 2016, 66: 4282-4288.

[56]Wang, Tietao; Yang, Xiaobing; Gao, Fen; Zhao, Chao; Kang, Yiwen; Wang, Yao; Shen, Xihui*.Zinc acquisition via ZnuABC in Yersinia pseudotuberculosis facilitates resistance to oxidative stress.Annals of Microbiology, 2016, 66(3): 1189-1197.

[57]Si, Meiru; Zhao, Chao; Zhang, Bing; Wei, Dawei; Chen, Keqi; Yang, Xu; Xiao, He; Shen, Xihui*.Overexpression of Mycothiol Disulfide Reductase Enhances Corynebacterium glutamicum Robustness by Modulating Cellular Redox Homeostasis and Antioxidant Proteins under Oxidative Stress.Scientific Reports, 2016, 6: 29491.

[58]Wang, Tietao; Gao, Fen; Kang, Yiwen; Zhao, Chao; Su, Tao; Li, Muhang; Si, Meiru; Shen, Xihui*.Mycothiol peroxidase MPx protects Corynebacterium glutamicum against acid stress by scavenging ROS.Biotechnology Letters, 2016, 38(7): 1221-1228.

[59]Liu, Yingbao; Yang, Xiaobing; Yin, Yajie; Lin, Jinshui; Chen, Can; Pan, Junfeng; Si, Meiru*; Shen, Xihui*.Mycothiol protects Corynebacterium glutamicum against acid stress via maintaining intracellular pH homeostasis, scavenging ROS, and S-mycothiolating MetE.Journal of General and Applied Microbiology, 2016, 62(3): 144-153. 

[60]Akbar, Ali; Chen, Chaoqiong; Zhu, Lingfang; Xin, Kaiyun; Cheng, Juanli; Yang, Qiao; Zhao, Liang; Zhang, Lei*; Shen, Xihui.Sphingomonas hylomeconis sp nov., isolated from the stem of Hylomecon japonica.International Journal of Systematic and Evolutionary Microbiology, 2015, 65: 4025-4031.

[61]Song, Yunhong; Xiao, Xiao; Li, Changfu; Wang, Tietao; Zhao, Ruoxi; Zhang, Weipeng; Zhang, Lei; Wang, Yao; Shen, Xihui*.The dual transcriptional regulator RovM regulates the expression of AR3- and T6SS4-dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis.Environmental Microbiology, 2015, 17(11): 4631-4645.

[62]Guan, Jingyuan; Xiao, Xiao; Xu, Shengjuan; Gao, Fen; Wang, Jianbo; Wang, Tietao; Song, Yunhong; Pan, Junfeng; Shen, Xihui*; Wang, Yao*.Roles of RpoS in Yersinia pseudotuberculosis stress survival, motility, biofilm formation and type VI secretion system expression.Journal of Microbiology, 2015, 53(9): 633-642.

[63]Xiao, Xiao#; Si, Meiru#; Yang, Zhifang; Zhang, Yaoling; Guan, Jingyuan; Chaudhry, Muhammad Tausif; Wang, Yao; Shen, Xihui*.Molecular characterization of a eukaryotic-like phenol hydroxylase from Corynebacterium glutamicum.Journal of General and Applied Microbiology, 2015, 61(4): 99-107.

[64]Si, Meiru; Xu, Yixiang; Wang, Tietao; Long, Mingxiu; Ding, Wei; Chen, Can; Guan, Xinmeng; Liu, Yingbao; Wang, Yao; Shen, Xihui*; Liu, Shuang-Jiang.Functional characterization of a mycothiol peroxidase in Corynebacterium glutamicum that uses both mycoredoxin and thioredoxin reducing systems in the response to oxidative stress.Biochemical Journal. 2015, 469(1):45-57. 

[65]Wang, Tietao#; Si, Meiru#; Song, Yunhong#; Zhu, Wenhan; Gao, Fen; Wang, Yao; Zhang, Lei; Zhang, Weipeng; Wei, Gehong; Luo, Zhao-Qing; Shen, Xihui*.Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity.PLoS Pathogens, 2015, 11(7): e1005020.

[66]Si, Meiru#; Wang, Jianbo#; Xiao, Xiao; Guan, Jingyuan; Zhang, Yaoling; Ding, Wei; Chaudhry, Muhammad Tausif; Wang, Yao*; Shen, Xihui*.Ohr Protects Corynebacterium glutamicum against Organic Hydroperoxide Induced Oxidative Stress.PLos One, 2015, 10(6): e0131634.

[67]Zhang, Weipeng; Sun, Jin; Ding, Wei; Lin, Jinshui; Tan, Renmao; Lu, Liang; Liu, Xiaofen; Shen, Xihui; Qian, Pei-Yuan*.Extracellular matrix-associated proteins form an integral and dynamic system during Pseudomonas aeruginosa biofilm development.Frontiers in Cellular and Infection Microbiology, 2015, 5: 40.

[68]Zhu, Lingfang#; Xin, Kaiyun#; Chen, Chaoqiong; Li, Changfu; Si, Meiru; Zhao, Liang; Shi, Xu; Zhang, Lei*; Shen, Xihui*.Sphingobium endophyticus sp nov., isolated from the root of Hylomecon japonica.Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 2015, 107(4): 1001-1008.

[69]Si, Meiru#; Zhang, Lei#; Chaudhry, Muhammad Tausif#; Ding, Wei; Xu, Yixiang; Chen, Can; Akbar, Ali; Shen, Xihui*; Liu, Shuang-Jiang.Corynebacterium glutamicum Methionine Sulfoxide Reductase A Uses both Mycoredoxin and Thioredoxin for Regeneration and Oxidative Stress Resistance.Applied and Environmental Microbiology, 2015, 81(8): 2781-2796.

[70]Zhu, Lingfang; Si, Meiru; Li, Changfu; Xin, Kaiyun; Chen, Chaoqiong; Shi, Xu; Huang, Ruijun; Zhao, Liang; Shen, Xihui; Zhang, Lei*。Sphingomonas gel sp nov., isolated from roots of Geum aleppicum.International Journal of Systematic and Evolutionary Microbiology, 2015, 65: 1160-1166.

[71]Wei, Linfang; Si, Meiru; Long, Mingxiu; Zhu, Lingfang; Li, Changfu; Shen, Xihui; Wang, Yao; Zhao, Liang; Zhang, Lei*.Rhizobacter bergeniae sp nov., isolated from the root of Bergenia scopulosa.International Journal of Systematic and Evolutionary Microbiology, 2015, 65: 479-484.

[72]Ding Wei#; Meiru Si#; Weipeng Zhang; Yaoling Zhang; Can Chen; Lei Zhang; Zhiqiang Lu; Shaolin Chen; Xihui Shen*.Functional characterization of a vanillin dehydrogenase in Corynebacterium glutamicum.Scientific Reports, 2015, 5(1): 8044.

[73]Lin, Jinshui#; Cheng, Juanli#; Chen, Keqi; Guo, Chenghao; Zhang, Weipeng; Yang, Xu; Ding, Wei; Ma, Li; Wang, Yao; Shen, Xihui*.The icmF3 locus is involved in multiple adaptation- and virulence-related characteristics in Pseudomonas aeruginosa PAO1.Front Cell Infect Microbiol, 2015, 5: 70.

[74]Si, Meiru; Long, Mingxiu; Chaudhry, Muhammad Tausif; Xu, Yixiang; Zhang, Pan; Zhang, Lei; Shen, Xihui*.Functional Characterization of Corynebacterium glutamicum Mycothiol S-Conjugate Amidase.PLos One, 2014, 9(12): e115075. 

[75]Zhu, Lingfang; Long, Mingxiu; Si, Meiru; Wei, Linfang; Li, Changfu; Zhao, Liang; Shen, Xihui; Wang, Yao; Zhang, Lei*.Asticcacaulis endophyticus sp nov., a prosthecate bacterium isolated from the root of Geum aleppicum.International Journal of Systematic and Evolutionary Microbiology, 2014, 64: 3964-3969.

[76]Cui, Boyu#; Zhang, Lifeng#; Song, Yunhong; Wei, Jinsong; Li, Changfu; Wang, Tietao; Wang, Yao; Zhao, Tianyong*; Shen, Xihui*.Engineering an Enhanced, Thermostable, Monomeric Bacterial Luciferase Gene As a Reporter in Plant Protoplasts.PLos One, 2014, 9(10): e107885.

[77]Zhang, Lei; Shi, Xu; Si, Meiru; Li, Changfu; Zhu, Lingfang; Zhao, Liang; Shen, Xihui; Wang, Yao*.Rhizobium smilacinae sp nov., an endophytic bacterium isolated from the leaf of Smilacina japonica.Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 2014, 106(4): 715-723.

[78]Zhang, Lei#; Zhu, Lingfang#; Si, Meiru; Li, Changfu; Zhao, Liang; Wei, Yahong; Shen, Xihui*.Solirubrobacter taibaiensis sp nov., isolated from a stem of Phytolacca acinosa Roxb.Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 2014, 106(2): 279-285. 

[79]Liu, Ying-Bao; Chen, Can; Chaudhry, Muhammad Tausif; Si, Mei-Ru; Zhang, Lei; Wang, Yao; Shen, Xi-Hui*.Enhancing Corynebacterium glutamicum robustness by over-expressing a gene, mshA, for mycothiol glycosyltransferase.Biotechnology Letters, 2014, 36(7): 1453-1459. 

[80]Cui, Boyu#; Wang, Yao#; Song, Yunhong; Wang, Tietao; Li, Changfu; Wei, Yahong; Luo, Zhao-Qing*; Shen, Xihui*.Bioluminescence Resonance Energy Transfer System for Measuring Dynamic Protein-Protein Interactions in Bacteria.mBio, 2014, 5(3): e01050-14.

[81]Zhang, Lei; Wei, Linfang; Zhu, Lingfang; Li, Changfu; Wang, Yao; Shen, Xihui*.Pseudoxanthomonas gei sp nov., a novel endophytic bacterium isolated from the stem of Geum aleppicum.Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 2014, 105(4): 653-661.

[82]Xu, Shengjuan#; Peng, Zhong#; Cui, Boyu; Wang, Tietao; Song, Yunhong; Zhang, Lei; Wei, Gehong; Wang, Yao*; Shen, Xihui*.FliS modulates FlgM activity by acting as a non-canonical chaperone to control late flagellar gene expression, motility and biofilm formation in Yersinia pseudotuberculosis.Environmental Microbiology, 2014, 16(4): 1090-1104. (cited by Faculty of 1000 Prime)  

[83]Si, Mei-Ru#; Zhang, Lei#; Yang, Zhi-Fang; Xu, Yi-Xiang; Liu, Ying-Bao; Jiang, Cheng-Ying; Wang, Yao; Shen, Xi-Hui*; Liu, Shuang-Jiang.NrdH Redoxin Enhances Resistance to Multiple Oxidative Stresses by Acting as a Peroxidase Cofactor in Corynebacterium glutamicum.Applied and Environmental Microbiology, 2014, 80(5): 1750-1762.

[84]Wei, Linfang; Ouyang, Shan; Wang, Yao; Shen, Xihui; Zhang, Lei*.Solirubrobacter phytolaccae sp nova., an endophytic bacterium isolated from roots of Phytolacca acinosa Roxb.International Journal of Systematic and Evolutionary Microbiology, 2014, 64: 858-862.

[85]Zhang L; Si M; Zhu L; Li C; Wei Y; Shen X*.Draft genome sequence of Nafulsella turpanensis ZLM-10T, a novel member of the family Flammeovirgaceae.Genome Announc, 2014, 2(2).

[86]Zhang, Lei#; Zhu, Lingfang#; Wei, Linfang; Li, Changfu; Wang, Yao; Shen, Xihui*.Pontibacter toksunensis sp nov., isolated from soil, and emended descriptions of Pontibacter roseus and Pontibacter akesuensis.International Journal of Systematic and Evolutionary Microbiology, 2013, 63: 4462-4468.

[87]Zhang, Lei; Wang, Yang; Wei, Linfang; Wang, Yao; Shen, Xihui*; Li, Shiqing.Taibaiella smilacinae gen. nov., sp nov., an endophytic member of the family Chitinophagaceae isolated from the stem of Smilacina japonica, and emended description of Flavihumibacter petaseus.International Journal of Systematic and Evolutionary Microbiology, 2013, 63: 3769-3776.

[88]Liu Ying Bao; Long Ming Xiu; Yin Ya Jie; Si Mei Ru; Zhang Lei; Lu Zhi Qiang; Wang Yao; Shen Xi Hui*.Physiological roles of mycothiol in detoxification and tolerance to multiple poisonous chemicals in Corynebacterium glutamicum.Archives of Microbiology, 2013, 195(6): 419-429.

[89]Zhang, Lei; Shen, Xihui; Liu, Yingbao; Li, Shiqing*.Nafulsella turpanensis gen. nov., sp nov., a member of the phylum Bacteroidetes isolated from soil.International Journal of Systematic and Evolutionary Microbiology, 2013, 63: 1639-1645.

[90]Ying-Bao Liu#; Ming-Xiu Long#; Ya-Jie Yin; Mei-Ru Si; Lei Zhang; Zhi-Qiang Lu; Yao Wang; Xi-Hui Shen*.Physiological roles of mycothiol in detoxification and tolerance to multiple poisounous chemicals in Corynebacterium glutamicum.Archives of Microbiology, 2013, 195(6): 419-429.

[91]Zhang, Weipeng#; Wang, Yao#; Song, Yunhong; Wang, Tietao; Xu, Shengjuan; Peng, Zhong; Lin, Xiaoli; Zhang, Lei; Shen, Xihui*.A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis.Environmental Microbiology, 2013, 15(2): 557-569.

[92]Shen, Xi-Hui; Zhou, Ning-Yi; Liu, Shuang-Jiang*.Degradation and assimilation of aromatic compounds by Corynebacterium glutamicum: Another potential for applications for this bacterium?.Applied Microbiology and Biotechnology, 2012, 95(1): 77-89.

[93]Gong, Jian; Shen, Xi-Hui; Qiu, Hui; Chen, Chao; Yang, Rong-Ge*.Rhesus Monkey TRIM5 alpha Has Distinct HIV-1 Restriction Activity Among Different Mammalian Cell Lines.Current Microbiology, 2011, 63(6): 531-537. 

[94]Gong, Jian; Shen, Xi-Hui; Qiu, Hui; Chen, Chao; Yang, Rong-Ge*.Rhesus monkey TRIM5 alpha represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated NF-kappa B activation.Archives of Virology, 2011, 156(11): 1997-2006.

[95]Gong J; Wang XQ; Tong X; Shen XH,; Yang RG*.Emerging trends of drug-resistant HIV-1 among drug-treated patients in former blood donors in Hubei, China: a three-year surveillance from 2004 to 2006.Virologica Sinica, 2011, 6(6): 386-392.

[96]Zhang, Weipeng; Xu, Shengjuan; Li, Jing; Shen, Xihui; Wang, Yao*; Yuan, Zhiming*.Modulation of a thermoregulated type VI secretion system by AHL-dependent Quorum Sensing in Yersinia pseudotuberculosis.Archives of Microbiology, 2011, 193(5): 351-363.

[97]Jian Gong; Xi-Hui Shen; Hui Qiu; Chao Chen; Rong-Ge Yang*.Down-regulation of HIV-1 infection by inhibition of the MAPK signaling pathway.Virologica Sinica, 2011, 26(2): 114-122. 

[98]Fontana, Mary F.; Banga, Simran; Barry, Kevin C.; Shen, Xihui; Tan, Yunhao; Luo, Zhao-Qing; Vance, Russell E.Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila.PLoS Pathogens, 2011, 7(2): e1001289.

[99]Xu, Li*; Shen, Xihui*; Bryan, Andrew; Banga, Simran; Swanson, Michele S.; Luo, Zhao-Qing*.Inhibition of Host Vacuolar H+-ATPase Activity by a Legionella pneumophila Effector.PLoS Pathogens, 2010, 6(3): e1000822.

[100]Xihui Shen#, Simran Banga#, Yancheng Liu, Li Xu, Ping Gao, Ilya Shamovsky, Evgeny Nudler, Zhao-Qing Luo. Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response. Cellular Microbiology. 2009, 11(6):911-926. 

[101]Huang, Yan; Zhao, Ke-Xin; Shen, Xi-Hui; Jiang, Chen-Ying; Liu, Shuang-Jiang*.Genetic and biochemical characterization of a 4-hydroxybenzoate hydroxylase from Corynebacterium glutamicum.Applied Microbiology and Biotechnology, 2008, 78(1): 75-83.

[102]Banga, Simran; Gao, Ping; Shen, Xihui; Fiscus, Valena; Zong, Wei-Xing; Chen, Lingling; Luo, Zhao-Qing*.Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family.Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(12): 5121-5126.

[103]Chaudhry, Muhammad Tausif; Huang, Yan; Shen, Xi-Hui; Poetsch, Ansgar; Jiang, Cheng-Ying; Liu, Shuang-Jiang*.Genome-wide investigation of aromatic acid transporters in Corynebacterium glutamicum.Microbiology-SGM, 2007, 153: 857-865.

[104]Feng, Jie; Che, Yongsheng; Milse, Johanna; Yin, Ya-Jie; Liu, Lei; Rückert, Christian; Shen, Xi-Hui; Qi, Su-Wei; Kalinowski, Jörn; Liu, Shuang-Jiang*.The gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum.Journal of Biological Chemistry, 2006, 281(16): 10778-10785.

[105]Huang, Yan; Zhao, Ke-Xin; Shen, Xi-Hui; Chaudhry Muhammad Tausif; Jiang, Cheng-Ying; Liu, Shuang-Jiang*.Genetic characterization of the resorcinol cataboiic pathway in Corynebacterium glutamicum.Applied and Environmental Microbiology, 2006, 72(11): 7238-7245.

[106]Xihui Shen, Shuang-Jiang Liu*. Molecular basis of the protocatechuate branch of the β-ketoadipate pathway for aromatic degradation in Corynebacterium glutamicum. Science in China 2005, 48: 241-249.

[107]Xi-Hui Shen; Yan Huang; Shuang-Jiang Liu*.Genomic analysis and identification of catabolic pathways for aromatic compounds in Corynebacterium glutamicum.Microbes and Environments, 2005, 20(3): 160-167.

[108]Shen, Xi-Hui; Jiang, Cheng-Ying; Huang, Yan; Liu, Zhi-Pei; Liu, Shuang-Jiang*.Functional identification of novel genes involved in the glutathione-independent gentisate pathway in Corynebacterium glutamicum.Applied and Environmental Microbiology, 2005, 71(7): 3442-3452.

[109]Xihui Shen, Zhipei Liu, and Shuang-Jiang Liu*. Functional identification of the gene locus (ncg12319) and characterization of catechol 1,2-dioxygenase in Corynebacterium glutamicum. Biotechnology Letters 2004, 26:575-580. 

发表中文期刊论文

[1]李梦园, 王逍, 杨亚东, 汤晶晶, 谢臻, 徐磊, 沈锡辉, 王瑶*. 鼠伤寒沙门氏菌sopF基因缺失突变体的构建及调节宿主自噬功能研究[J]. 动物医学进展, 2023, 44 (03): 1-7.

[2]李梦园, 王逍, 沈锡辉, 王瑶, 徐磊*. STING介导的天然免疫反应在细菌感染中作用研究进展[J]. 动物医学进展, 2023, 44 (02): 84-88.

[3]赵文瑾, 尚道涵, 谢来工, 沈锡辉, 张磊*. 铜绿假单胞菌环二鸟苷酸代谢及其调控生物膜形成研究进展[J]. 中国病原生物学杂志, 2022, 17 (12): 1468-1474.

[4]于宗兰, 朱凯祥, 张辰, 潘大敏, 杨彦涛, 沈锡辉. 铜绿假单胞菌PA14 H3-T6SS的调控功能研究[J]. 西北农林科技大学学报(自然科学版), 2023, 51 (06): 123-130.

[5]尹雁玲, 蔡然, 张功良, 杨彦涛, 刘兴宇, 沈锡辉*. 植物内生菌增强植物对生物胁迫抗性的研究进展[J]. 广西植物, 2023, 43 (02): 212-220.

[6]谢臻, 汤晶晶, 沈锡辉, 郭抗抗*, 徐磊*. 细菌外膜囊泡调节宿主天然免疫反应机制研究进展[J]. 动物医学进展, 2022, 43 (05): 78-83.

[7]谢晓荣, 尚道涵, 沈锡辉, 张磊*. AI-2通过调节c-di-GMP代谢酶DosC影响类志贺邻单胞菌生物膜形成及运动性[J]. 微生物学报, 2022, 62 (07): 2808-2823.

[8]杨昶杏, 孟凡能*, 张文越, 杨培钰, 王丹丹, 刘兴宇, 王瑶*, 沈锡辉. 假结核耶尔森氏菌中Phd-Doc毒素-抗毒素系统的功能鉴定[J]. 微生物学通报, 2021, 48 (10): 3554-3568.

[9]Meiru Si, Yao Wang, Bing Zhang, Chao Zhao, Yiwen Kang, Haonan Bai, Dawei Wei, Lingfang Zhu, Lei Zhang, Tao G.Dong, 沈锡辉. 细菌六型分泌系统利用一个受氧化还原调节的双功能血红素转运蛋白获取锌[J]. 科学新闻, 2018, (04): 137.

[10]杨志方, 肖潇, 司美茹, 成娟丽, 沈锡辉, 王瑶. 谷氨酸棒杆菌中苯酚羟化酶的鉴定及功能研究[J]. 西北农林科技大学学报(自然科学版), 2015, 43 (12): 191-198.

[11]高奋; 王铁涛; 朱玲芳; 沈锡辉*.假结核耶尔森氏菌VI型分泌系统T6SS-2的抑菌功能研究.中国科技论文在线, 2014, 0(0): 1-6.  

[12]张磊, 沈锡辉. 改革微生物学实验教学模式 培养创新型人才[J]. 教育教学论坛, 2012, (38): 25-26.

[13]沈锡辉,刘双江*. 谷氨酸棒杆菌中芳香化合物降解的β-酮己二酸途径中原儿茶酸分支关键酶的鉴定[J]. 中国科学C辑:生命科学, 2004, 34(06): 547-554.

[14]沈锡辉,刘志培,王保军,刘双江*. 苯酚降解菌红球菌PNAN5菌株(Rhodococcussp.strain PNAN5)的分离鉴定、降解特性及其开环双加氧酶性质研究[J]. 环境科学学报, 2004,34 (03): 482-486.

[15]吴建峰,沈锡辉,周宇光,刘双江. 一株降解对氯硝基苯的Comamonas sp.CNB1的分离鉴定及其降解特性[J]. 微生物学报, 2004, (01): 8-12. 

[16]沈锡辉,王开梅,张志刚,陈在佴,镇达. 用离子交换吸附法回收Bt发酵液上清中的增效物质[J]. 中国生物防治, 2004, (01): 34-37. 

[17]陈在佴,吴继星,张志刚,王海林,廖先清,沈锡辉. 我国苏云金杆菌液体深层发酵研究十年进展(1990-2000)[J]. 中国生物防治, 2002, (01): 33-35.

[18]王瑶,林木兰,沈锡辉,柳晟. 农杆菌介导的木本植物遗传转化[J]. 生物技术通报, 1999, (06): 23-27.

[19]罗淑平,李发民,沈锡辉. 陕西省玉米杂交种种质基础分析[J]. 西北农林科技大学学报(自然科学版), 1995, (S2): 46-51.  

[20]郭呈昊; 林金水; 王瑶; 沈锡辉*.细菌VI型分泌系统结构与功能的研究进展中国科技论文在线.

发表会议论文

[1]沈锡辉.细菌VI型分泌系统的抗环境胁迫功能研究.第十八次全国环境微生物学学术研讨会, 中国,江苏省,镇江市, 2015-11-21至2015-11-24.

[2]沈锡辉.细菌VI型分泌系统与环境胁迫.中国遗传学会大会，微生物遗传学与环境分会场, 中国,云南省,昆明市, 2015-08-14至2015-08-18.

[3]沈锡辉.假结核耶尔森氏菌VI型分泌系统的新功能.病原细菌的化学生物学研讨会, 中国,贵州省,贵阳市, 2015-04-18至2015-04-20.

[4]Gong, Jian; Shen, Xihui; Yang, Rongge.RHESUS MONKEY TRIM5A REPRESSES HIV-1 LTR PROMOTER ACTIVITY VIA NEGATIVELY REGULATING TLR-MEDIATED NF-KB PATHWAY

[5]Ziqiang, Du1, 2*; Yudan, Shen3; Jian, Wang1; Xihui, Shen1, 4.A remote sensing-based integrated approach for monitoring grassland degradation: Case study on the representative grassland near the middle and upper reaches of Heihe River basin, western China.Remote Sensing and Modeling of Ecosystems for Sustainability IV, 2007-08-28 to 2007-08-29.

[6]刘双江,沈锡辉,黄燕,亓苏伟,M．Tausif Chaudhry,冯婕... & 姜成英. (2006). 谷氨酸棒杆菌(Corynebacterium glutamicum)降解芳香化合物的功能基因组学. (eds.) 首届全国微生物基因组学学术研讨会会程与论文摘要集 (pp.31). 

[7]沈锡辉; 刘双江.谷氨酸棒杆菌(Corynebacterium glutamicum)降解芳香化合物的功能基因组学分析.第七次全国环境微生物学术研讨会, 中国,上海市, 2004-10-23.

 

荣誉奖励：

1、西北农林科技大学“青年英才培养计划”首届入选者。

2、2017年获批国家杰出青年科学基金项目。

 农业与环境微生物团队

团队介绍 

西北农林科技大学生命学院“农业与环境微生物”研究团队依托旱区作物逆境生物学国家重点实验室，瞄准微生物领域国际科技前沿，紧密围绕国家战略需求和区域发展需要，深入开展面向西部旱区农业生产实际的基础和应用基础研究，形成了一支学术氛围浓郁，规章制度完善，年龄梯度和知识结构合理的科研生力军。团队现有教授2人，副教授1人，讲师4人，博士后、研究生共40余人。 

团队带头人沈锡辉教授为国家杰出青年科学基金获得者，入选国家“万人计划”、科技部中青年科技创新领军人才推进计划和陕西省特支计划。 

沈锡辉教授在细菌六型分泌系统的离子转运与抗环境胁迫新功能、植物内共生微生物促作物抗旱抗逆机制、微生物-环境-宿主相互作用机制研究等方面取得了比较突出的进展，以通讯作者在Nature Communications、PNAS、Cell Reports等国际著名期刊发表SCI论文50余篇。研究成果“微生物主动运输新机制”被中国微生物学会推荐为2017年度“中国生命科学领域十大进展”唯一参评项目。在2017年国家杰出青年基金评选中，作为国家基金委生命科学部唯一来自西部的答辩人并成功入选，也是我校自2012年以来唯一的国家杰青入选者。 

团队事迹 

团队在研究生培养过程中，不仅注重对研究生科学精神和科研能力的培养，还注意将思想政治教育融入课程和科研活动，潜移默化地培养研究生的爱国主义情怀，教育引导学生“诚实做人，诚信做事”，努力营造“追求卓越、协同创新、踏实勤奋、勇于奉献”的团队文化，团队成员团结友爱，互帮互助，通力合作。 

团队一贯重视对青年人才的培养，尽全力通过多种方式招募人才组建团队，精心为年轻人制定发展规划，设计研究计划，提供良好的事业发展空间和机会，同时在生活中给予青年人无微不至的关怀，通过事业、感情和手把手的传帮带聚集了一批有潜力的青年人才共同为西部农业微生物和绿色可持续发展的宏大目标而奋斗。 

团队还积极为本科生提供科研实践的机会，凡有对微生物感兴趣的同学参观实验室都热情接待，引导感兴趣的同学参与大学生科创、科研训练和毕业论文设计等，吸引学生提前进入实验室实践，并在过程中悉心指导，引导学生对科研产生兴趣，提升学生的探索意识和科学精神。 

优秀毕业生 

博士生司美茹以一作在PNAS，Cell Reports，Antioxidants & Redox Signaling等国际顶尖期刊发表多篇高水平SCI论文，其中一篇被Faculty of 1000推荐，被聘为曲阜师范大学生命学院副教授、硕士生导师。 

博士生林金水以一作在Nature Communications（ESI高被引论文），Frontiers in Cellular and Infection Microbiology等发表SCI论文多篇，入选陕西高校首批“青年杰出人才”计划和陕西省 “特支计划”区域发展人才。 

张伟鹏入选中国海洋大学“英才工程”和“优青培育计划”，被聘为教授、博士生导师。 

博士生崔博宇和王铁涛分别获得陕西省第一届和第二届创新成果展暨创新成果洽谈会一等奖。 

有多名研究生获得国家奖学金、大北农奖学金、优秀党员、优秀毕业生、优秀研究生等荣誉称号。 

团队人才 

青年教师张磊自加入团队以来发表SCI论文20余篇（含双一流A类文章1篇），主持国家自然科学基金2项，晋升为副教授、博士生导师。 

青年教师徐磊来校后已发表SCI论文多篇，申请到国家自然科学基金青年项目、中国博士后特别资助、陕西省博士后特别资助、中国博士后面上资助（一等）和陕西省基础科学研究项目（青年）等多项资助，累计获批科研经费92万元，由其负责的科研项目已取得重要进展，有望冲击顶级期刊。 

团队荣誉 

沈锡辉教授带头的农业与环境微生物团队以立德树人为根本，以为党育人、为国育才为责任和使命，以丰硕的育人成效、卓越的科研业绩、高效的团队管理取得了令人瞩目的成绩。 

该团队是师德高尚的优秀团队。团队教师言传身教，以崇高的师德师风和精湛的业务能力教育学生影响学生，培养的研究生在各自领域建功立业，人才培养成效显著。多名研究生在Nature、Nature Communications、PNAS等国际知名期刊上发表研究论文，多名研究生在学期间获评国家奖学金、优秀研究生等荣誉称号。 

该团队是精诚团结的战斗团队。团队成员有极强的组织力和凝聚力，教职工党员占80%，研究生党员占60%，团队建设有明确的目标，有为实现目标制定的详细规划，团队成员有干劲、有拼劲、有闯劲，共同竖起了我国西部农业微生物研究领域的一面旗帜。 

该团队是追求卓越的先锋团队。团队成员仰望星空的同时铭记脚踏实地，用一个个日月星辰的坚守和拼搏，取得了令人瞩目的成绩。团队带头人是我校自2012年以来唯一的国家杰青入选者，团队成员均有卓越的科研业绩，团队成员有极为可观的发展前景和广阔的发展空间。 

该团队有突出的业绩贡献，团队成员严谨治学、追求卓越，在微生物领域的研究达到国内一流水平，收到领域内专家的一致好评，在我国西部地区独树一帜。 

该团队在立德树人工作中取得了显著成绩。团队培养的研究生政治素养过硬、理论基础扎实、业务能力精湛，毕业后奋斗在各行各业，为祖国的教育、科研和“三农”事业贡献力量。 

来源: 党委宣传部   2022-06-30 

 

本科、硕士就读于西农，在中科院微生物所攻读微生物学博士，又在美国普度大学生物科学系作博士后，最终于2010年从武汉病毒所病毒学国家重点实验室回到母校。一路走来，沈锡辉始终在与微生物“打交道”，闯出了属于自己的一片天地。 

“三年困难时期” 

“当时学校正在实施人才强校战略，我又是陕西人，觉得学校微生物研究基础很好，回来发展前景广阔，于是就选择回到家乡、回到母校工作。” 

万事开头难。刚回来，一切都要重新开始，当时无论是经费还是人员、实验室都比较紧张，而且前三年也没有文章产出，压力可想而知。当时和沈锡辉一起到校的张伟鹏硕士，暂时没有安排住宿，为了不耽误实验，就在实验室地上铺床坚持了一个多月。 

“学校给的50万元科研启动经费能保障工作正常运转，但要想保证科研工作不断线，还要不断申请基金等项目。”沈锡辉说，幸运的是成功申请到了基金，又得到了学校一些支持计划、重点项目等的支持，这对当时正处于爬坡过坎阶段的沈锡辉来说，每一笔经费都是雪中送炭。 

有了经费，还要有人。当时经常是招到合适的人了，对方突然说不来了，那么当年就没有博士生了，又得等一年。这种状况直到2017年以后才有所好转。 

找准研究方向 

来校后，沈锡辉经过认真思考，选择细菌六型分泌系统作为主要研究方向。细菌六型分泌系统在2006年才开始发现，沈锡辉算是进入这个领域比较早的。他告诉记者，无论是在动物肠道还是在植物根系都有很多微生物，因为营养、生长空间等有限，微生物之间也存在竞争，而且经常是你死我活。细菌六型分泌系统其实就是一种竞争的主要武器。有些细菌在肠道或根系的生存能力强，就是因为有这个比较强大的武器。所以就是想通过研究把这个武器的功能揭示出来，以后在工业、农业或者健康方面，通过合成生物学的手段来加以改造、利用。 

目前沈锡辉团队围绕细菌六型分泌系统主要开展的是理论研究，为将来与学校作物、园艺、动科、动医等方面的交叉打下基础。比如肠道里有个病原菌侵染了，没法治疗，但如果找到另外一个菌或者改造一个菌，它有更强大的竞争力，就可以把坏的细菌消灭掉。作物上基本也是这个思路。 

微生物菌群不仅有竞争，还有合作。沈锡辉研究的另外一方面，就是微生物之间存在怎样的“对话交流”，从而达到互相的平衡和谐。“‘和谈’不成就会启动‘战争’，像人与人之间一样。这种对话是否也会跨界，比如说细菌与真菌之间、甚至是细菌和它的宿主之间是如何对话的？这也是团队现在关注的一个研究方向。”沈锡辉表示。 

打造知名团队 

作为学校旱区作物逆境生物学与绿色生产学科群团队之一，沈锡辉团队有教授3名、副教授4名，讲师2名，博士研究生10余名，硕士研究生30余名，还有部分本科生参与，主要围绕微生物、分子生物学和生物化学开展工作。 

沈锡辉对团队有着明确的目标，那就是把团队初步打造成微生物领域国内知名团队。按照这个目标，沈锡辉认为团队还需要进一步完善，重点是引进生物信息学、结构生物学方面人才，从而让团队学科结构更加完整，竞争力更强。 

沈锡辉十分重视学科交叉。学校现有的植物保护、畜牧学两个一流学科，与团队微生物方向十分吻合。肠道微生物研究有助于和畜牧学学科结合，植物生防菌研究有助于揭示病原菌的防控机制，能和植物保护学科紧密结合。目前，团队有关动物肠道微生物的研究已在PNAS、NC等期刊发表多篇文章，植物保护方面目前已和黄丽丽教授团队展开合作。此外，和资环学院有关专家也开展了合作。“团队只有跟学校发展方向密切结合才能发展进步。学校微生物研究实力雄厚，希望齐心协力把学校微生物学科做大做强，为学校的学科发展作出我们积极的贡献。”沈锡辉说。 

争取进入“国家队” 

沈锡辉组建大团队时间不长，通过外部引进和内部吸收，招收了不少年轻人，团队整体比较年轻。他认为，年轻人有干劲、有闯劲，要好好爱护、培养，成为骨干力量。比如去年留在团队的两个年轻人都做得很好，其他几个年轻人也都很有发展潜力，要努力把他们培养成国家级青年人才。只有把年轻人培养起来，团队才能做大做强。 

作为团队负责人，沈锡辉也思考谋划着团队未来，如何把这样一支年轻的队伍带好。“基础研究和应用研究一定要双轮驱动。下一步我们想在合成生物学方面有所作为。因为合成生物学主要依赖于微生物，目前已上升为国家战略，将来在农业生产应用等方面前景广阔。”沈锡辉介绍，目前已有直接把二氧化碳合成淀粉的技术，将来是不是也可以合成油、合成更多蛋白质？学校目前参加合成生物学重点专项的团队比较少，自己团队也只是参加了一些课题和子课题。 

“我们希望将来能主持合成生物学方面的项目，从而把合成生物学广泛应用于农业生产。比如在动物肠道和植物根系方面怎样进行合成生物学改造，提高它的功能。方向选好了，我们研究的问题、开展的工作才会有科学价值，才能真正对国民经济和农业生产作出贡献，真正把文章写在大地上。”沈锡辉表示。